A5072083206- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Regulation of Appetite and Obesity
- T-cell and B-cell Immunology
- Developmental Biology and Gene Regulation
- Marine animal studies overview
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Cell Image Analysis Techniques
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Neuroscience and Neural Engineering
- Glycosylation and Glycoproteins Research
- Eating Disorders and Behaviors
- Hearing, Cochlea, Tinnitus, Genetics
- Cell Adhesion Molecules Research
- Chronic Disease Management Strategies
- Electrolyte and hormonal disorders
- Nuclear Receptors and Signaling
- Barrier Structure and Function Studies
- Blood disorders and treatments
- Reproductive System and Pregnancy
- Hearing Loss and Rehabilitation
- Global Public Health Policies and Epidemiology
University of the Basque Country
2011-2025
Achucarro Basque Center for Neuroscience
2017-2025
Asociación Colombiana de Facultades de Ingeniería
2022
Universidad de Antioquia
2009
Sociedad Española de Endocrinología y Nutrición
2002
Hospital Universitario Puerta del Mar
1998-2000
Jefferson College
1995
The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA spatial transcriptomics, mathematical modeling to compare the development evolution of known pallial across birds (chick), lizards (gecko), mammals (mouse). reveal neurons within these circuits’ stations generated at varying developmental times brain regions species found an early divergence in...
OBJECTIVE: To evaluate the T helper 1 (T(H)1)/T 2 (T(H)2) lymphocyte cytokine profiles in women and men to study vitro effects of sex hormones on secretion cytokines. METHODS: Analysis serum concentration synthesis T(H)1 (gamma interferon (INF-gamma) interleukin (IL-2)) T(H)2 (interleukin 4 (IL-4) 10 (IL-10)) cytokines was performed 20 15 men. modifications induced by supplementation culture with increasing concentrations carried out. RESULTS: Higher levels INF-gamma IL-2 lower IL-4 IL-10...
Despite strong evidence supporting that both astrocytes and apolipoprotein E (APOE) play crucial roles in the pathogenesis progression of Alzheimer's disease (AD), impact carrying different APOE variants on key AD pathological hallmarks remains largely unknown. To explore such effects a human relevant context, we generated chimeric model AD. We transplanted isogenic APOE3 or APOE4 induced pluripotent stem cell (hiPSC)-derived astrocyte progenitors into neonatal brains mice. show at five to...
Abstract Microglia, the immune cells of central nervous system, continuously survey brain to detect alterations and maintain tissue homeostasis. The motility microglial processes is indicative their surveying capacity in normal pathological conditions. gold standard technique study involves use two‐photon microscopy obtain time‐lapse images from slices or cortex living animals. This generates four dimensionally‐coded which are analyzed manually using time‐consuming, non‐standardized...
Abstract The amniote pallium contains sensory circuits structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. Our study employs birthdating analysis, single-cell RNA spatial transcriptomics, mathematical modeling to compare the development evolution of known pallial across birds (chick), lizards (gecko) mammals (mouse). We reveal that neurons within these circuits’ stations are generated at varying developmental times brain regions species, found an...
Embryonic development is a complex and dynamic process that unfolds over time involves the production diversification of increasing numbers cells. The impact developmental on formation central nervous system well documented, with evidence showing plays crucial role in establishing identity neuronal subtypes. However, study how translates into genetic instructions driving cell fate limited by scarcity suitable experimental tools. We introduce BirthSeq, new method for isolating analyzing cells...
The auditory receptor epithelium is an excellent model system for studying the differential expression of ion channel genes. An inward rectifier potassium current among those which have been measured in only subsets chick cochlear hair cells. We cloned and characterized (cIRK1) from sensory epithelium. cIRK1 functional properties are similar to native channel, transcript encoding limited low frequency half This localization agreement with distribution cell current, suggesting that...
ABSTRACT Embryonic development is a complex and dynamic process that unfolds over time involves the production of increasing numbers cells, as well diversification different cell types. The impact developmental on formation central nervous system well-documented, with evidence showing plays critical role in establishing identity neuronal subtypes. However, study how translates into genetic instructions driving fate limited by scarcity suitable experimental tools. We introduce BirthSeq , new...
The distribution of peripheral blood CD16/56 cytotoxic T and natural killer (NK) cells in Graves' disease patients is analyzed order to correlate them with activity prognosis. Eighteen disease, twenty-four Hashimoto's thyroiditis thirty-two sex- age-matched healthy control subjects were studied. Peripheral (cytotoxic NK) by cytofluorometry. A decreased proportion CD16/56+ CD16/ 56+CD3+ detected when compared groups. No correlation was serum free thyroxine. On diagnosis, who would require a...
We have prospectively examined the percentage of peripheral blood lymphocytes which expressed adhesion molecules in untreated Graves' disease patients. Eighteen patients with disease, twenty-four Hashimoto's thyroiditis and thirty-two sex- age-matched healthy control subjects were studied. The expression lymphocyte beta-1 integrin CD29, beta-2 CD11b L-selectin Leu8 (CD62L) was analyzed by cytofluorometry. A decreased CD29+ CD11b+ observed hyperthyroid comparison controls. However, there no...
In the present paper distribution of peripheral blood T gamma/delta Iymphocytes in Graves' disease patients is analyzed order to correlate them with activity and prognosis. Eighteen disease, 24 Hashimoto's thyroiditis 32 sex- age-matched healthy control subjects were studied. Peripheral CD3+ alpha/beta lymphocytes as well CD4+ CD8+ cells, CD19 (B) by cytofluorometry. At diagnosis, who required a radical treatment for thyrotoxicosis showed significant decrease an increase B cells when...