A5034788614- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Renal Transplantation Outcomes and Treatments
- Complement system in diseases
- Reproductive Biology and Fertility
- Polyomavirus and related diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Polyamine Metabolism and Applications
- Cancer and Skin Lesions
- Reproductive System and Pregnancy
- Urticaria and Related Conditions
- Atherosclerosis and Cardiovascular Diseases
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Drug Transport and Resistance Mechanisms
- Sodium Intake and Health
- Nail Diseases and Treatments
- Viral-associated cancers and disorders
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Herpesvirus Infections and Treatments
- Liver physiology and pathology
- Transplantation: Methods and Outcomes
Kyoto University
1984-2023
Humboldt-Universität zu Berlin
2023
Charité - Universitätsmedizin Berlin
2023
Freie Universität Berlin
2023
Max Delbrück Center
2023
German Centre for Cardiovascular Research
2023
Japan Science and Technology Agency
2017-2018
Shiga University of Medical Science
1988
Commencing oogenesis In mice, embryonic stem cells and induced pluripotent have been shown to differentiate into primordial germ cell–like that can give rise functional oocytes. this system, Nagaoka et al. identified the gene Zglp1 as a necessary sufficient factor for conferring oogenic fate sexually undetermined cells. As downstream effector of bone morphogenetic protein signaling, conserved transcriptional regulator ZGLP1 activates program repressed by Polycomb activities, whereas retinoic...
Antibody-mediated rejection (AMR) remains a refractory after donor-specific antibody (DSA)-positive or blood-type incompatible liver transplantation (LT), even in the era of pre-transplant rituximab desensitization. This is due to lack not only effective post-transplant treatments but also robust animal models develop/validate new interventions. Orthotopic LT from male Dark Agouti (DA) Lewis (LEW) rats was used develop rat LT-AMR model. LEW were pre-sensitized by preceding skin DA 4–6 weeks...
Post-transplant lymphoproliferative disorders (PTLDs) are life-threatening neoplasms after organ transplantation. Because of their rarity and multiple grades malignancy, the incidence, outcomes, clinicopathological features affecting patient survival liver transplantation (LT) remain unclear. We reviewed 1954 LTs in 1849 recipients (1990-2020), including 886 pediatric (<18 years age) 963 adult recipients. The following factors were studied: age, sex, etiologies, malignancy grades,...
Background. Hepatic ischemia/reperfusion injury (IRI) is a serious complication in liver surgeries, including transplantation. Complement activation seems to be closely involved hepatic IRI; however, no complement-targeted intervention has been clinically applied. We investigated the therapeutic potential of 5 (C5)-targeted regulation IRI. Methods. C5-knockout (B10D2/oSn) and their corresponding wild-type mice (WT, B10D2/nSn) were exposed 90-minute partial (70%) with either anti-mouse-C5...
Hepatic ischemia/reperfusion injury (IRI) often causes serious complications in liver surgeries, including transplantation. Complement activation seems to be involved hepatic IRI; however, no complement-targeted intervention has been clinically applied. We investigated the therapeutic potential of Properdin-targeted complement regulation IRI. Male wild-type mice (B10D2/nSn) were exposed 90-minute partial IRI left and median lobes with either monoclonal anti-Properdin-antibody (Ab) or...
Background & AimsAcute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied. In this study, we aimed to investigate potential of Complement-5 (C5)-targeted treatment.MethodsALF was induced in C5-knockout (KO, B10D2/oSn) mice and their wild-type (WT) counterparts (B10D2/nSn) through intraperitoneal lipopolysaccharide (LPS)...
Donor-recipient human leukocyte antigen (HLA) compatibility has not been considered to significantly affect liver transplantation (LT) outcomes; however, its significance in living-donor LT (LDLT), which is mostly performed between blood relatives, remains unclear. This retrospective cohort study included 1954 LDLTs at our institution (1990-2020). The primary and secondary endpoints were recipient survival the incidence of T cell-mediated rejection (TCMR) after LDLT, respectively, according...
An autopsied case of extramammary Paget's disease associated with the elevation serum CEA level is reported. abnormally high was found in 46% patients this disease.
Six-month recipient mortality after adult-to-adult living-donor liver transplantation (LDLT) remains high. Early and accurate prediction of outcome continuous monitoring severity surgery are both essential for guiding appropriate care. This study was designed to identify early post-transplant parameters associated with 6-month mortality, thereby construct a discriminatory prognostic index (PI).We retrospectively analyzed 400 consecutive primary LDLTs in our center (2006-2017). Perioperative...
Thirty-eight biopsies of prurigo lesions (22 large, mature nodules and 16 smaller, intermediately developed nodules) were obtained from 17 patients with idiopathic nodularis Hyde who had not been bitten by insects, nor other underlying diseases. Each biopsy was serially sectioned to reveal its histological structure. In 88% (14/16) the smaller in 55% (12/22) large ones, a hair follicle observed center lesion. The follicular epidermis adjacent surface showed various degrees acanthosis...
Current critical shortage of donor organs has increased the use donation after circulatory death (DCD) livers for transplantation, despite higher risk primary nonfunction or ischemic cholangiopathy. Human atrial natriuretic peptide (hANP) is a cardiovascular hormone that possesses protective action to vascular endothelia. We aimed clarify therapeutic potential hANP in cold storage DCD livers.Male Wistar rats were exposed 30-minute warm ischemia situ. Livers then retrieved and cold-preserved...