A5042020445- Healthcare Technology and Patient Monitoring
- COVID-19 Clinical Research Studies
- Radiology practices and education
- Cardiac Arrest and Resuscitation
- Epigenetics and DNA Methylation
- Growth Hormone and Insulin-like Growth Factors
- Pharmacological Receptor Mechanisms and Effects
- Long-Term Effects of COVID-19
- TGF-β signaling in diseases
- COVID-19 and healthcare impacts
- Mitochondrial Function and Pathology
- Emergency and Acute Care Studies
- SARS-CoV-2 and COVID-19 Research
- Metabolism, Diabetes, and Cancer
- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- dental development and anomalies
- Patient Safety and Medication Errors
- Botulinum Toxin and Related Neurological Disorders
- Bipolar Disorder and Treatment
- Connective tissue disorders research
- Disaster Response and Management
- Osteoarthritis Treatment and Mechanisms
- Healthcare Systems and Public Health
The University of Texas Southwestern Medical Center
2017-2023
Parkland Health & Hospital System
2017-2023
Macquarie University
2013
MED Institute
2011
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2006-2010
National Institutes of Health
2006-2010
Centro de Investigacion Principe Felipe
2008
University of Kansas Medical Center
2008
University Medical Center
2008
University of Kansas
2008
Background: Obesity may contribute to adverse outcomes in coronavirus disease 2019 (COVID-19). However, studies of large, broadly generalizable patient populations are lacking, and the effect body mass index (BMI) on COVID-19 outcomes— particularly younger adults—remains uncertain. Methods: We analyzed data from patients hospitalized with at 88 US hospitals enrolled American Heart Association’s Cardiovascular Disease Registry collection through July 22, 2020. BMI was stratified by World...
In the growth plate, stem-like cells in resting zone differentiate into rapidly dividing chondrocytes of proliferative and then terminally non-dividing hypertrophic zone. To explore molecular switches responsible for this two-step differentiation program, we developed a microdissection method to isolate RNA from (RZ), (PZ), zones (HZ) 7-day-old male rats. Expression approximately 29,000 genes was analyzed by microarray selected verified real-time PCR. The analysis identified whose expression...
Catch-up growth is defined as a linear rate greater than expected for age after period of inhibition. We hypothesized that catch-up occurs because growth-inhibiting conditions conserve the limited proliferative capacity plate chondrocytes, thus slowing normal process senescence. When condition resolves, plates are less senescent and therefore grow more rapidly age. To test this hypothesis, we administered propylthiouracil to newborn rats 8 wk induce hypothyroidism then stopped allow growth....
Previous studies of the GH–IGF system gene expression in growth plate using immunohistochemistry and situ hybridization have yielded conflicting results. We therefore studied spatial temporal patterns mRNA rat proximal tibial quantitatively. Growth plates were microdissected into individual zones. RNA was extracted, reverse transcribed analyzed by real-time PCR. In 1-week-old animals, IGF-I minimal compared with perichondrium, metaphyseal bone, muscle, liver (70-, 130-, 215-, 400-fold less)....
In embryonic growth cartilage, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP) participate in a negative feedback loop that regulates chondrocyte differentiation. Postnatally, this region undergoes major structural functional changes. To explore the organization of Ihh–PTHrP system postnatal plate, we microdissected plates 7-day-old rats into their constituent zones assessed expression genes participating loop. Ihh , Patched 1, Smoothened, Gli1, Gli2, Gli3 Pthr1 were...
The human TOMM34 gene encodes a cytosolic protein with chaperone-like activity that helps import some preproteins to the mitochondria by keeping them in an unfolded, import-compatible state. was found be upregulated frequently colorectal tumors, suggesting it also has role growth of cancer cells. In this context, is potential target for novel anticancer drugs, and might used diagnosis cancer. Nuclear respiratory factors (NRFs) play important governing nuclear-mitochondrial interactions...
Background: An in silico screen was performed to identify FDA approved drugs that inhibit SARS-CoV-2 main protease (Mpro), followed by vitro viral replication assays, and vivo pharmacokinetic studies mice. These identified atovaquone as a promising candidate for inhibiting replication. Methods: A 2-center, randomized, double-blind, placebo-controlled trial among patients hospitalized with COVID-19 infection. Enrolled were randomized 2:1 1500 mg BID versus matched placebo. Patients received...
Delays in treatment of in-hospital cardiac arrests (IHCAs) are associated with worsened survival. We sought to assess the impact a bundled intervention on IHCA survival patients centralised telemetry. A retrospective quality improvement study was performed which incorporated (1) telemetry hotline for technicians reach nursing staff; (2) empowerment directly activate response team and (3) standardised escalation system automated critical alerts within mobile phone system. In 4-year period,...
The Infectious Diseases Society of America consensus guidelines recommend a 5 day duration therapy for community-acquired pneumonia (CAP) patients who have been afebrile 48 to 72 hours and ≤1 CAP-associated sign clinical instability. Shorter durations minimize the emergence selection resistant organisms, increase adherence, reduce risk medication adverse effects. This retrospective review evaluated from January December 2015. Criteria inclusion were age ≥18 years, principal billing diagnosis...
INTRODUCTION: Soft tissue filler injections have been associated with a 0.01-0.1% risk of granuloma formation.1 This may form between 2 weeks to years post injection. In the past, this was considered type IV hypersensitivity reaction.2 Recent evidence, however, has suggested that be due bacterial infection.3 Subclinical infection formation biofilms (a mixture low numbers bacteria protected in their surrounding excreted polysaccharide) shown cause chronic inflammation around prosthetic...
Background: Delays in treatment of in-hospital cardiac arrest (IHCA) events are associated with lower survival and poor neurologic outcomes. With centralized telemetry, telemetry technicians need to notify nursing staff life-threatening arrhythmias immediately for verify a patient's clinical status determine whether code blue activation is necessary. this verification lead delays activation, which can turn increased morbidity mortality. Objective: We sought assess the impact empowering...
ABSTRACT Background An in-silico screen was performed to identify FDA approved drugs that inhibit SARS-CoV-2 main protease (M pro ), followed by in vitro viral replication assays, and vivo pharmacokinetic studies mice. These identified atovaquone as a promising candidate for inhibiting replication. Methods A 2-center, randomized, double-blind, placebo-controlled trial among patients hospitalized with COVID-19 infection. Enrolled were randomized 2:1 1500 mg BID versus matched placebo....
The COVID-19 pandemic has been associated with front line health care provider burnout, depression, and post-traumatic stress disorder. We sought to better understand how nurses physicians of differing genders may have affected differently by the crisis. Between July 17, 2020, October 31, we surveyed caring for patients at a large, academic, public safety net hospital in southern United States. Survey questions were adapted from validated questionnaires used determine quality life, assess...