A5101452306- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cancer Research and Treatments
- Air Quality and Health Impacts
- Impact of Light on Environment and Health
- Animal Virus Infections Studies
- RNA Interference and Gene Delivery
- Neurological Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- Spine and Intervertebral Disc Pathology
- Neurological Disease Mechanisms and Treatments
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Immune cells in cancer
- Circadian rhythm and melatonin
- Signaling Pathways in Disease
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Garlic and Onion Studies
- Cell death mechanisms and regulation
- Seaweed-derived Bioactive Compounds
- Pesticide and Herbicide Environmental Studies
- NF-κB Signaling Pathways
Northeast Agricultural University
2024
Anhui Medical University
2021-2022
China National Pharmaceutical Group Corporation (China)
2021
Baotou Medical College
2020-2021
Zhengzhou University
2013-2021
Third Affiliated Hospital of Inner Mongolia Medical College
2021
Jinzhou Medical University
2011-2021
Shantou University
2020
Henan Provincial People's Hospital
2015
First Affiliated Hospital of Liaoning Medical University
2011-2013
We performed a phase I trial of FANG vaccine, an autologous tumor-based product incorporating plasmid encoding granulocyte-macrophage colony-stimulating factor (GMCSF) and novel bifunctional short hairpin RNAi (bi-shRNAi) targeting furin convertase, thereby downregulating endogenous immunosuppressive transforming growth factors (TGF) β1 β2. Patients with advanced cancer received up to 12 monthly intradermal injections vaccine (1 × 10(7) or 2.5 cells/ml injection). GMCSF, TGFβ1, TGFβ2,...
In this study, Spirulina platensis (S.p.) polysaccharide (PSP) was obtained by ultrasonic-microwave-assisted extraction (UMAE) and purified an aqueous two-phase system (ATPS). Two different methods were applied to (PSP), respectively, due PSP as a complex multi-component system. Three fractions (PSP-1, PSP-2, PSP-3) with acidic groups after fractionated the diethyl aminoethyl (DEAE)-52 cellulose chromatography, two (PSP-L PSP-H) molecular weight ultrafiltration centrifugation. The...
Abstract Purpose: On the basis of hypothesis that combined expression immunostimulatory granulocyte macrophage colony stimulating factor (GM-CSF) and antitumor suppressor TGF-β2 antisense (AS) transgenes can break tolerance stimulate immune responses to cancer-associated antigens, we constructed an plasmid [the tumor-associated glycoprotein (TAG) plasmid] coexpresses GM-CSF AS nucleotide sequences which was incorporated into autologous whole-cell vaccine. Experimental Design: Patients...
Atrazine (ATR) is widely used worldwide as a commercial herbicide, Diaminochlorotriazine (DACT) the main metabolite of ATR in organism. both them disrupt production steroids and induce abnormal reproductive development. The granulosa cells (GCs) are important for growth reproduction animals. However, toxicity on GCs birds not well clarified. To evaluate effect environmental pollutant bird GCs. quail were allotted into 7 groups, C (The medium M199), A20 (20 µM ATR), A100 (100 A250 (250 D20...
<i>Background:</i> To circumvent the problem of transporting anticancer drugs across blood-brain barrier (BBB) to target brain tumors, we have previously developed dual-targeting daunorubicin liposomes modified with 4-aminophenyl-α-<i>D</i>-manno-pyranoside and transferrin molecules. The objective present study was evaluate pharmacokinetics distribution after intravenous administration liposomes. <i>Methods:</i> We evaluated pharmacological parameters in...
Cinobufagin (CBG), a major bioactive component of the traditional Chinese medicine ChanSu, has been reported to have potent pharmacological activity. In this study, we aimed elucidate effects CBG on activity immune cells in mice. Peritoneal macrophages and splenocytes from mice were prepared cultured RPMI1640 supplemented with 10% fetal bovine serum. Concanavalin (ConA), lipopolysaccharide (LPS), (0.0125, 0.05, 0.15, or 0.25 μg/mL) added culture medium, phagocytic was detected by MTT assays....
Context: Cadmium (Cd2+) is an important industrial and environmental pollutant has been shown to induce apoptosis in a variety of cell types tissues. Objective: To assess the specific effects low-dose Cd2+ on skin. This organ easily exposed Cd2+, but how it damages cells not fully understood. Materials methods: Mouse skin fibroblasts were treated with low doses (0.4, 0.8 or 1.6 μM) for 12–48 h, we observed morphological alterations, measured DNA damage quantified viability changes. Results:...
To understand the association between cytokine network and psoriasis, present study cultured human keratinocytes (HaCaT cells) investigated effects of phosphatidylinositol‑3‑kinase (PI3K) p55 regulatory subunit (p55PIK), its N‑terminal 24 amino acids (N24) on regulation endotoxin (LPS)‑induced secretion. The results enzyme‑linked immunosorbent assay reverse transcription quantitative polymerase chain reaction revealed an increased release inflammatory cytokines, tumor necrosis factor...
Excessive exposure to light at night (LAN) has become a serious public health concern. However, little is known about the impact of indoor LAN on blood pressure, particularly among young adults. To investigate effects bedroom individual-level in real-world environment pressure and hypertension vulnerable adults, evaluate possible buffering effect physical activity. In this cross-sectional study, total 400 healthy adults aged 16 22 years were included. Bedroom was recorded 1-minute intervals...
Vascular dementia (VD) is a cerebral dysfunction. Brain neuropeptide analogue Rattin firstly found in rat brain tissue and plays treatment effect Alzheimer’s disease. However, its function related mechanism VD still needs elucidation. Rats were randomly separated into sham group, model group followed by analysis of learning ability Morris water maze, level real time PCR Western blot, Bcl-2 Bax levels BDNF expression immunofluorescence. mRNA protein was reduced, downregulated, upregulated,...
Increased Hcy has a toxic effect on nerve cells and can cause hippocampal death directly damage the body’s cognitive function memory ability, leading to occurrence of vascular dementia. predicts disease might be basis for clinical judgment. This article provides new prevention treatment this by exploring mechanism action memantine hydrochloride in diabetic After grouping, mice walked through Morris water maze record escape latency, measured level high performance liquid chromatography....