A5056799345- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Bone and Dental Protein Studies
- Acute Myeloid Leukemia Research
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Protease and Inhibitor Mechanisms
- Bone and Joint Diseases
- Hematopoietic Stem Cell Transplantation
- Galectins and Cancer Biology
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Hematological disorders and diagnostics
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Bone Tissue Engineering Materials
- Cancer, Hypoxia, and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- TGF-β signaling in diseases
- Congenital heart defects research
Max Planck Institute for Molecular Biomedicine
2019-2024
Morpho (United States)
2024
University of Münster
2019-2024
SRM Institute of Science and Technology
2016-2019
SRM University
2016-2017
Mesenchymal stem cells (MSCs) are multipotent and their differentiation into the osteoblastic lineage is strictly controlled by several regulators, including microRNAs (miRNAs). Runx2 a bone transcription factor required for osteoblast differentiation. Here, we used in silico analysis to identify number of miRNAs that putatively target its co‐factors mediate both positive negative regulation Among these miRNAs, miR‐590‐5p was selected expression found be increased during When mouse MSCs...
Blood vessels are integrated into different organ environments with distinct properties and physiology (Augustin Koh, 2017). A striking example of organ-specific specialization is the bone vasculature where certain molecular signals yield opposite effect as in other tissues (Glomski et al., 2011; Kusumbe 2014; Ramasamy 2014). Here, we show that transcriptional coregulators Yap1 Taz, components Hippo pathway, suppress vascular growth hypoxic microenvironment bone, contrast to their...
Abstract Bone regeneration requires a well-orchestrated cellular and molecular response including robust vascularization recruitment of mesenchymal osteogenic cells. In femoral fractures, angiogenesis osteogenesis are closely coupled during the complex healing process. Here, we show with advanced longitudinal intravital multiphoton microscopy that early vascular sprouting is not directly to osteoprogenitor invasion calvarial bone regeneration. Early osteoprogenitors emerging from periosteum...
Abstract The bone marrow microenvironment is a critical regulator of haematopoietic stem cell self-renewal and fate 1 . Although it appreciated that ageing, chronic inflammation other insults compromise function thereby negatively affect haematopoiesis 2 , not known whether different compartments exhibit distinct microenvironmental properties functional resilience. Here we use imaging, pharmacological approaches mouse genetics to uncover specialized in adult ageing skull. Specifically, show...
Abstract Parathyroid hormone (PTH) acts on osteoblasts and functions as an essential regulator of calcium homeostasis a mediator bone remodeling. We previously reported that PTH stimulates the expression matrix metalloproteinase‐13 (MMP‐13) in rat MMP‐13 plays key role remodeling, endochondral formation, repair. Recent evidence indicated microRNAs (miRNAs) have regulatory metabolism. In this study, we hypothesized down‐regulation miRNAs target by leads to stimulation osteoblasts. used...
The vasculature of the skeletal system is crucial for bone formation, homoeostasis and fracture repair, yet diversity specialization bone-associated vessels remain poorly understood. Here we identify a specialized type post-arterial capillary, termed R, involved in remodelling. Type R capillaries emerge during adolescence around trabecular bone, possess distinct morphology molecular profile, are associated with osteoprogenitors bone-resorbing osteoclasts. Endothelial cell-specific...
<title>Abstract</title> Arterial blood transport into peripheral organs is indispensable for developmental growth, homeostasis and tissue repair. While it appreciated that defective formation or compromised function of arteries associated with a range human diseases, the cellular molecular mechanisms mediating arterial development remain little understood most organs. Here, we show genetic approaches small subpopulation endothelial cells inside intestinal villi embryonic mouse, characterized...
<title>Abstract</title> The bone marrow microenvironment is a critical regulator of hematopoietic stem cell self-renewal and fate. While it appreciated that aging, chronic inflammation other insults compromise function thereby negatively affect hematopoiesis, not known whether different compartments exhibit distinct microenvironmental properties functional resilience. Here, we have employed imaging, pharmacological approaches, mouse genetics to uncover specialized highly surprising in adult...