A5103126587- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Forest ecology and management
- Liver Disease and Transplantation
- Thermoregulation and physiological responses
- Building Energy and Comfort Optimization
- HIV/AIDS drug development and treatment
- Remote Sensing and LiDAR Applications
- Genetic and phenotypic traits in livestock
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Infrared Thermography in Medicine
- Exercise and Physiological Responses
- Constraint Satisfaction and Optimization
- Acute Lymphoblastic Leukemia research
- Biochemical and Molecular Research
- Soil erosion and sediment transport
- HIV Research and Treatment
- Animal Virus Infections Studies
- Evolution and Genetic Dynamics
- Peptidase Inhibition and Analysis
- Alcohol Consumption and Health Effects
- Vitamin D Research Studies
Umeå Plant Science Centre
2024
Swedish University of Agricultural Sciences
2024
University of Gothenburg
2012-2021
Sahlgrenska University Hospital
2006-2021
Region Västra Götaland
2020-2021
Swedish National Heritage Board
2018
Forestry Research Institute of Sweden
2018
University of Central Florida
2008-2010
Noble Hospital
2008
Erasmus University Rotterdam
2006
We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4.Plasma IP-10 was monitored before, during, after pegylated IFN- alpha 2a ribavirin 265 HCV-infected patients.In univariate analyses, a low baseline level significantly associated load, rapid response (RVR), sustained (SVR), body mass index <25 kg/m2, less-pronounced...
Plasma from 173 patients with HCV genotype 1 infection was analyzed for IP-10 levels prior to treatment pegylated interferon-alpha-2a and ribavirin. Significantly lower were observed in achieving a rapid viral response (RVR) (P < .0001), even those body mass index (BMI) > or = 25 kg/m2 .004) baseline load 2 million IU/mL .001). Similarly, significantly obtaining sustained (SVR) .0002), including having higher BMI .05), .0005), both .03). In multivariate logistic regression analyses, low...
Previous trials investigating the efficacy of treatment durations shorter than standard 24 weeks for chronic hepatitis C virus (HCV) genotype 2/3 infections have yielded discordant results. The aims this investigator-initiated phase III study were to compare 12 or and identify patients suitable short-term therapy. Three hundred eighty-two 2/3–infected [intention-to-treat (ITT) population] at 31 centers in Denmark, Finland, Norway, Sweden randomized peginterferon α-2a (180 μg/week) plus...
Background High baseline levels of IP-10 predict a slower first phase decline in HCV RNA and poor outcome following interferon/ribavirin therapy patients with chronic hepatitis C. Several recent studies report that single nucleotide polymorphisms (SNPs) adjacent to IL28B spontaneous resolution infection treatment among genotype 1 infected patients. Methods Findings In the present study, we correlated occurrence variants at three such SNPs (rs12979860, rs12980275, rs8099917) pretreatment...
Abstract Purpose of Review In this review, we synthesise current knowledge on trade-offs among traits in key fitness dimensions and identify major research gaps with the intention laying groundwork for a rapid advance tree breeding multiple objectives as contribution to sustainability planted forests future. Recent Findings Trade-offs growth, reproduction, defence, stress tolerance product quality predicted theoretically have been reported experimentally many programmes. Among these...
Assessment of liver histology is pivotal in prognostication and decision-making regarding therapeutic intervention patients with chronic hepatitis C virus (HCV). Being an invasive procedure, the biopsy associated complications, a non-invasive alternative would be preferable.
High systemic levels of interferon-gamma-inducible protein 10 kDa (IP-10) at onset combination therapy for chronic hepatitis C virus (HCV) infection predict poor outcome, but details regarding the impact IP-10 on reduction HCV RNA during remain unclear. In present study, we correlated pretreatment in liver biopsies (n = 73) and plasma 265) with throughout within a phase III treatment trial (DITTO-HCV). Low or intrahepatic were strongly associated pronounced first 24 hours all patients ( P...
Abstract: Background/Methods: In order to evaluate the progression of liver fibrosis associated with Hepatitis C virus (HCV) infection, two biopsy specimens obtained prior antiviral therapy from 98 patients HCV were scored and evaluated using statistical methods appropriate for ordered categorical data. Results/conclusions: Greater was seen increasing time between biopsies. Likewise, change in score significantly more pronounced 11 whose first within year after acquiring HCV. A multivariate...
Liver steatosis is highly prevalent in chronic hepatitis C virus (HCV) infection, especially patients infected with genotype 3 virus, but its significance for the outcome of antiviral treatment not fully understood. We have monitored liver biopsies from 231 HCV infection who received pegylated recombinant interferon-alpha and ribavirin a phase III study (DITTO trial). The degree steatosis, along relevant metabolic parameters, was correlated early disappearance final treatment. Our data...
Single-nucleotide polymorphisms upstream of the interleukin 28B (interferon λ3) gene (IL28B) strongly influence treatment efficacy in patients carrying hepatitis C virus (HCV) genotype 1. In receiving 12 or 24 weeks interferon-ribavirin therapy for infection with 2 3 (n = 341), we found that rs12979860 strikingly determined first phase viral elimination (P < .001). treated weeks, also predicted rate sustained virologic response .02), especially among those high baseline HCV RNA levels .002)...
Single nucleotide polymorphisms (SNPs) upstream of IL28B predict the outcome treatment in chronic hepatitis C virus (HCV) infection, but their impact on viral kinetics and relation to other predictors are not well known. Here, two SNPs, rs12979860 rs8099917, were analysed related early during 110 patients with HCV genotype 1 infection. The reduction RNA after 7 days therapy was more pronounced (P < 0.0001) CC(rs12979860) or TT(rs8099917) than carrying TT(rs12979860) GG(rs8099917),...
Patients infected with hepatitis C virus (HCV) genotype 1 respond poorly to standard treatment 50% or less achieving sustained virologic response. Predicting outcome is essential and could help avoid unnecessary reduce health cost. Recently, an association of amino acid substitutions in the core region was observed Japanese patients. In present study, impact these mutations on response kinetics explored Caucasian patients.The HCV pre-treatment samples obtained from 50 patients treated...
The present study evaluated the impact of variations in inosine triphosphate pyrophosphatase (ITPase) gene (ITPA) on treatment outcome patients with hepatitis C virus (HCV) genotype 2/3 infection receiving peginterferon-α2a and lower, conventional 800 mg daily dose ribavirin. Previous studies using higher, weight-based ribavirin dosing report that carrying polymorphisms encoding reduced predicted ITPase activity show decreased risk ribavirin-induced anemia but increased thrombocytopenia, no...
Background and Aims Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well outcome following peginterferon ribavirin therapy among genotype 1 infected patients. The present study aimed evaluate the impact SNP variability on liver histology context a phase III treatment trial (NORDynamIC) for treatment-naïve patients with chronic 2 or 3 infection, where...
Objective. The results of a previous study suggest that an index calculated according to the formula (normalized ASAT×PK-INR)×100/thrombocyte count (×109/L; GUCI) may reflect liver fibrosis in patients with chronic hepatitis C virus (HCV) infection. aims present were (i) validate association between Göteborg University Cirrhosis Index (GUCI) score and (ii) evaluate utility this predicting outcome antiviral treatment. Material methods. A total 269 HCV infection, stratified genotype (1/4...
Summary. In hepatitis C virus (HCV) genotype 1 infection, the likelihood of obtaining sustained virological response (SVR) is associated with higher ribavirin exposure. Such an association has not been demonstrated for HCV 2/3 where a fixed 800 mg daily dosing generally recommended. The primary aim this study was to investigate correlation between concentration at day 29 and therapeutic in patients infection. A total 382 were randomized 12 or 24 weeks treatment pegylated interferon‐alfa 2a...
Background and Aims Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of hepatitis C virus (HCV) infection as well outcome following pegylated interferon ribavirin therapy among genotype 1 infected patients. Additionally the presence otherwise favorable genetic variants context HCV 3 reportedly entail more pronounced liver fibrosis steatosis. The present study aimed evaluate impact...
Abstract Background Hepatic steatosis in HCV patients has been postulated as a risk factor associated with higher frequency of fibrosis and cirrhosis. A single genetic variant, PNPLA3 I148M, widely increased hepatic steatosis. Previous studies the I148M sequence variant infected individuals have reported an association between this prevalence steatosis, fibrosis, To evaluate impact on metabolic traits treatment response genotype 2 3 patients. Methods Three hundred eighty-two naïve or were...
Background and Aims Having a body mass index above or equal to 30 kg/m2 in conjunction with chronic hepatitis C virus infection is associated non-responsiveness treatment interferon ribavirin, but details regarding the mechanisms whereby obesity reduces efficacy of therapy remain unclear. Methods This study evaluated impact on outcome as well ribavirin concentrations following standard-of-care fixed dosing peginterferon-α2a 180 µg once weekly 800 mg daily among 303 HCV genotype 2/3-infected...
Objective. Case reports and short-term clinical trials have suggested that treatment for chronic hepatitis B (CHB) may lead to improvement of cirrhosis. The aim the present study was measure liver stiffness in patients diagnosed with advanced fibrosis or cirrhosis prior prolonged nucleoside nucleotide analogs (NUCs) CHB. Materials methods. Patients CHB NUCs at least 1 year were offered inclusion study. We measured using transient elastography (TE) follow-up. TE cut-off levels Metavir...