This study aimed to evaluate changes in dietary and lifestyle habits during the period of confinement due first wave COVID-19 pandemic Ibero-American countries. A cross-sectional investigation was conducted with 6,325 participants both genders (68% women), over 18 years age from five countries: Brazil ( N = 2,171), Argentina 1,111), Peru 1,174), Mexico 686), Spain 1,183). Data were collected year 2020, between April 01 June 30 July 13 September 26, other countries studied using a...

Abstract Background Hormone-refractory prostate cancer (HRPC) is characterized by poor response to chemotherapy and high mortality, particularly among African American men when compared other racial/ethnic groups. It generally accepted that docetaxel, the standard of care for HRPC, primarily exerts tumor cell death inducing mitotic catastrophe caspase-dependent apoptosis following inhibition microtubule depolymerization. However, there a gap in our knowledge mechanistic events underlying...

Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due widespread distribution strategic positioning, acids play a crucial role in mediating regulating wide range physiologic processes pathologic...

Lipotoxicity involves a series of pathological cellular responses after exposure to elevated levels fatty acids. This process may be detrimental normal homeostasis and cell viability. The present study shows that nerve growth factor-differentiated PC12 cells (NGFDPC12) rat cortical (RCC) exposed high palmitic acid (PA) exhibit significant lipotoxicity death linked an "augmented state oxidative stress" (ASCOS). ASCOS response includes generation reactive oxygen species (ROS), alterations in...

Global health agencies estimate an increase of chronic diseases in South America. Nevertheless, few studies have investigated and their risk factors the perspective multimorbidity. This research aimed to identify these aspects a primary care setting central Argentina. The Pan America version STEP wise approach surveillance (STEPS) instrument World Health Organization was applied 1044 participants, 365 men 679 women, with mean age 43 years. High prevalence overweight (33.5%), obesity (35.2%),...

Chia seeds (Salvia hispanica) provide an unusually high content of α-linolenic acid with several potential health benefits, but few studies have examined the long-term intake n-3 fatty acid-rich plant foods such as chia. In this work, we investigated some effects a diet containing 10% chia versus conventional isocaloric for 10 and 13 months on body measurements, musculoskeletal system, liver, intestines 20 male Sprague-Dawley rats assigned into two groups. The n-6/n-3 ratios control diets...

Cancer is the second most important non-communicable disease worldwide and disproportionately impacts low- to middle-income countries. Diet in combination with other lifestyle habits seems modify risk for some cancers but little known about South Americans. Food of Argentinean men pre- post-diagnosis prostate cancer (n = 326) were assessed along factors. We studied whether any behaviors factors found 394), compared control subjects 629). Before diagnosis, both cases reported a greater mean...

Abstract There is increasing evidence that an augmented state of cellular oxidative stress modulates the expression genes implicated in diseases associated with health disparities such as certain cancers and diabetes. Lens epithelium–derived growth factor p75 (LEDGF/p75), also known DFS70 autoantigen, emerging a survival oncoprotein promotes resistance to stress–induced cell death chemotherapy. We previously showed LEDGF/p75 targeted by autoantibodies prostate cancer patients overexpressed...

Although current research has contributed to the promotion of whole-food plant-based diets, few studies have examined healthy vegan dietary and lifestyle factors, especially in South America. Therefore, we aimed at investigating adherence habits among Argentinian vegetarians omnivorous, using a recently developed vegetarian index adapted pattern. Also, accessibility foods, proportion household income spent on food were assessed cross-sectional approach with 1454 participants. The population...

Studies were carried out to analyse the kidney histopathological alterations of "curimbatá", Prochilodus lineatus, analyzed. An acute bioassay was made by water contamination with 0.2muml/l Dipterex 500 (Trichlorfon). The tissue collected after 24 hours exposure showed an enlargement intercapsular space glomerular atrophy, hypertrophy tube cells, small granules on its cytoplasm and little nuclear alteration. Blood overflowing from capillaries pyknotic nuclei vacuoles in it also noticed....

Abstract Objective Autoantibodies to DNA topoisomerase I (topo I) are associated with diffuse systemic sclerosis (SSc), appear be antigen driven, and may triggered by cryptic epitopes exposed during in vivo topo fragmentation. These autoantibodies recognize fragments of this autoantigen generated apoptosis necrosis. We undertook study determine whether lysosomal cathepsins involved fragmentation Methods Topo cleavage necrosis was assessed immunoblotting lysates from L929 fibroblasts tumor...

Abstract Sialic acids (Sias) are a class of sugar molecules with parent nine-carbon neuraminic acid, generally present at the ends carbohydrate chains, either attached to cellular surfaces or as secreted glycoconjugates. Given their position and structural diversity, Sias modulate wide variety biological processes. However, little is known about role in human adipose tissue, implications for health disease, particularly among individuals following different dietary patterns. The goal this...

The present study evaluated the factors associated with perception of anxiety during first wave covid-19 in Ibero-American countries. This cross-sectional was carried out 5.845 participants both sexes, over 18 years age, and residents four Latin American countries–Argentina (16.7%), Brazil (34.5%), Mexico (11.1%), Peru (17.5%), one European country–Spain (20.1%). Data were collected 2020, between April 1st June 30th Spain July 13th September 26th We used an online questionnaire...

Sepsis is a major public health problem, frequent, costly, and often fatal. Despite of improvements in supportive treatments the incidence sepsis number deaths related to increasing. Statins have been recently proposed as adjuvants treatment sepsis, but its effects on mortality show conflicting results worldwide.The purpose this study was describe clinical outcome patients diagnosed with university-affiliated hospital central Argentina evaluate it relation group septic previous use statins...

This study aimed to validate a semiquantitative electronic food frequency questionnaire (eFFQ) in estimating the intake of comprehensive list nutrients and bioactive compounds among adults from six regions Argentina using multiple 24 h dietary recall (24HR) as reference. A total 163 completed two administrations eFFQ four 24HRs. The paired t-test/Wilcoxon signed-rank test, Spearman/Pearson correlations, cross-classification, weighted kappa statistics, Bland–Altman plots were employed...

Granulocytes of the epigonal and Leydig organs Rhizoprionodon lalandii were identified classified into three different cell types, type I II eosinophils neutrophils. The development these cells in haematopoietic tissues was dynamic, demonstrated by nuclear immunopositivity for proliferating antigen (PCNA) proteins regulated various cytokines, including transforming growth factor β ‐l (TGF/ 1 ). expression pattern heterogeneous among individual TGF/ ‐immunostaining found principally cytoplasm...

Histopathologic lesions in the liver of juvenile Prochilodus lineatus were assessed following 24 and 48h exposure to organophosphate pesticide Dipterex 500 ® (Trichlorfon) at a concentration 0.2 µl/L. Livers experimental animals collected, processed, stained with hematoxylin eosin according routine histology methods. Alterations hepatic tissue observed after exposure, including lateral migration nuclei, variation diameter density pyknosis necrosis

An effective way to address risk factors for non-communicable chronic diseases (NCD) and reduce healthcare costs is by using sound health-related advice (HRA) promote healthy lifestyle habits. In Argentina, however, few studies have examined the context in which HRA communicated undertaken patients at primary care level. this study, we assessed reception of a mixed-method approach central area Argentina. A total 1,044 participants from community were contacted sociodemographic...

Background: Latin American countries show a fast-growing rate of non-communicable diseases (NCDs) and diet is critical risk factor that must be properly assessed. Automated dietary assessment tools to collect 24-h recalls (24HR) are lacking in Argentina. Objective: This study aimed develop an open-access automated tool (MAR24) for collecting 24HR using multiple pass method database containing foods recipes commonly consumed Methods: MAR24 was developed based on data from 1,285 provided by...