A5080141967- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Medical Imaging Techniques and Applications
- Mitochondrial Function and Pathology
- Cell death mechanisms and regulation
- S100 Proteins and Annexins
- Medical Imaging and Pathology Studies
- PARP inhibition in cancer therapy
- Phagocytosis and Immune Regulation
- Glioma Diagnosis and Treatment
- Boron Compounds in Chemistry
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Cancer Treatment and Pharmacology
- Nuclear Physics and Applications
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Protease and Inhibitor Mechanisms
- Gut microbiota and health
- Sirtuins and Resveratrol in Medicine
- Monoclonal and Polyclonal Antibodies Research
- Anesthesia and Neurotoxicity Research
- Hippo pathway signaling and YAP/TAZ
Loma Linda University
2007-2024
Wake Forest University
2016-2018
Atrium Health Wake Forest Baptist
2016
Loma Linda University Medical Center
2013
University of California, Irvine
2008
Fibroblast activation protein (FAP) is a promising target for diagnosis and therapy of numerous malignant tumors. FAP-2286 the conjugate FAP-binding peptide, which can be labeled with radionuclides theranostic applications. We present first-in-human results using <sup>177</sup>Lu-FAP-2286 peptide-targeted radionuclide (PTRT). <b>Methods:</b> PTRT was performed in 11 patients advanced adenocarcinomas pancreas, breast, rectum ovary after prior confirmation uptake on...
The tumour microenvironment is believed to be involved in development, growth, metastasis, and therapy resistance of many cancers. Here we show survivin, a member the inhibitor apoptosis protein (IAP) family, implicated inhibition regulation mitosis cancer cells, exists novel extracellular pool cells. Furthermore, have constructed stable cell lines that provide with either wild-type survivin (Surv-WT) or previously described dominant-negative mutant (Surv-T34A), which has proven...
Abstract Background Hormone-refractory prostate cancer (HRPC) is characterized by poor response to chemotherapy and high mortality, particularly among African American men when compared other racial/ethnic groups. It generally accepted that docetaxel, the standard of care for HRPC, primarily exerts tumor cell death inducing mitotic catastrophe caspase-dependent apoptosis following inhibition microtubule depolymerization. However, there a gap in our knowledge mechanistic events underlying...
Prostate cancer (PCa) is the most common noncutaneous malignancy in men. Until recent years, accurate imaging of men with newly diagnosed PCa, or recurrent low-volume metastatic disease, was limited. Further, therapeutic options for advanced, metastatic, castration-resistant disease were increasingly limited as a result increasing numbers systemic therapies being combined upfront setting. The advent urea-based, small-molecule inhibitors prostate-specific membrane antigen (PSMA) has partially...
Insulin-like growth factor II (IGF-II) plays a pivotal role in fetal and cancer development by signaling through the IGF-I insulin receptors activating estrogen cascade. We previously showed that precursor IGF-II (proIGF-II, predominant form expressed cancer) not mature (mIGF-II) blocks resveratrol (RSV) (a phytoalexin/anticancer agent)-induced cell death MCF-7 cells. hypothesize proIGF-II regulates antiapoptotic proteins and/or mitochondria to inhibit RSV actions promote survival. This...
89Zr immuno-PET continues to be assessed in numerous clinical trials. This report evaluates the use of 89Zr-chloride radiolabeling monoclonal antibodies conjugated with desferrioxamine B (DFO), describes its effects on radiopharmaceutical reactivity toward antigen, and offers guidance how ensure long-term stability purity. Methods:89Zr-DFO-trastuzumab 89Zr-DFO-cetuximab were prepared using 89ZrCl4 The each was evaluated for 7 d 20 mM histidine/240 sucrose buffer, 0.25 M sodium acetate...
IGF-II plays a crucial role in fetal and cancer development by signaling through the IGF-I receptor. We have shown that inhibition of resveratrol (RSV) induced apoptosis proIGF-II (highly expressed cancer) was more potent than mIGF-II inhibiting this effect. Thus, we hypothesized differentially regulates cascade receptor to stimulate anti-apoptotic proteins Bcl-2 Bcl-XL prevent apoptosis. RSV treatment breast cells inhibited expression mitochondrial membrane depolarization. ProIGF-II in: (1)...
TPS247 Background: Metastatic castrate resistant prostate cancer (mCRPC) is an advanced and lethal form of cancer. Prostate-specific membrane antigen (PSMA)-targeted theranostic agents, 68 Ga-PSMA-11 177 Lu-PSMA-617, have been approved by the FDA for patient selection therapy patients with mCRPC, respectively. Approximately 25% mCRPC show low or no PSMA expression. Consequently, these are unlikely to benefit from PSMA-targeted agents represent a significant unmet need both imaging therapy....
TPS346 Background: Between 20-40% of patients with prostate cancer (PC) will relapse within 10 years their primary PC treatment, as identified through rising prostate-specific antigen (PSA) levels. Early diagnosis biochemical recurrence (BCR) accurate staging is essential to informing optimal treatment decision-making. Approximately 20% biochemically recurrent show low or no PSMA expression on membrane (PSMA)-targeted PET. Consequently, these are unlikely benefit from PSMA-targeted agents...
Abstract INTRODUCTION AND OBJECTIVE: Enolase-1 (ENO1) and -2 (ENO2) are implicated in tumor metabolic aggressive functions. Like prostate specific membrane antigen (PSMA), they localize to the cell surface potential theranostics targets. ENO autoantibodies were reported by our group cancer (PCa) patients but their immunoreactivity ENO1/2 isoforms was not defined. Differential docetaxel-resistant (DR) PCa cells between African American (AA) European (EA) also reported. Our objective...
Abstract Prostate cancer (PCa) is American men's second most common cancer. Although taxane-based chemotherapy the last line of defense for Metastatic Castration Resistant Cancer (mCRPC), it invariably fails due to chemoresistance. The protein-specific membrane antigen (PSMA) has been an effective target imaging and therapy mCRPC. PSMA radioligand (PSMA-RLT) a theranostics option men with advanced PCa, about 30% have limited response neuroendocrine-like PCa (NEPC), which lacks expression....
Abstract Metastatic prostate cancer (PCa) is the leading cause of PCa-associated deaths and one causes mortality in men. Novel therapeutics, such as Prostate Specific Membrane Antigen (PSMA) ligand therapy, are emerging effective treatment strategies for metastatic cancer. However, most men succumb to Castration Resistant Cancer (mCRPC) due resistance. MAGMAS, a 13.8 kDa mitochondrial protein, imports nuclear-encoded proteins into matrix. MAGMAS overexpressed several aggressive tumors,...
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology III (PD35)1 May 2024PD35-10 RACE-RELATED DIFFERENTIAL IMMUNOREACTIVITY OF ENOLASE AUTOANTIBODIES IN PATIENTS WITH PROSTATE CANCER Kai Wen Cheng, Carlos J. Diaz Osterman, Krystal Santiago, Michael Reeves, Diano Lozano, Pedro Ochoa, Alfonso Duran, Saied Mirshahidi, Brian R. Hu, Frankis Almaguel, and A. Casiano ChengKai Cheng , OstermanCarlos Osterman SantiagoKrystal Santiago ReevesMichael Reeves LozanoDiano...
Abstract Prostate cancer (PCa) is the most common malignancy diagnosed in men U.S., with African American (AA) patients harboring high risk for more aggressive disease. Enolase (ENO) autoantibodies have been detected PCa, and race-related differential immunoreactivity to ENO docetaxel-resistant (DR) PCa cells described between AA European (EA) patients. In this study we evaluated frequency of distinct isoforms (ENO1 ENO2) EA patient sera their corresponding associations clinicopathological...
Abstract Prostate cancer (PCa) is American men's second most common cancer. This exhibits the significant racial disparities among all types, with elevated incidence and mortality in men of African ancestry. Although taxane-based chemotherapy docetaxel (DTX) cabazitaxel last line defense for metastatic Castration Resistant Cancer (mCRPC), it invariably fails due to development chemoresistance. The protein-specific membrane antigen (PSMA) currently an effective target imaging therapy mCRPC....
Abstract Prostate cancer (PCa) is the most commonly diagnosed malignancy and second leading cause of cancer-related death among men in United States (U.S.). Strikingly, African ancestry (AA) are 1.7 times more likely to be with PCa than twice as die European origin (EU). These disparities driven by socioeconomic, lifestyle, environmental, biological/genetic factors. Prostate-specific antigen screening limited identifying aggressive exposes increased harm minimal reduction mortality from PCa....
Abstract Disclosure: K. Granados: None. A. Durán: F. Almaguel: D. De Leon: Our laboratory previously showed that Insulin-like growth factor II (IGF-II) promotes cell proliferation, inhibits apoptosis and induces chemoresistance of Breast Cancer (BC) cells. We demonstrated IGF-II achieves this by inhibiting pro-apoptotic proteins stimulating anti-apoptotic proteins. Those studies also prevented mitochondrial induced depolarization the membrane. Thus, regulates mitochondria to prevent death...
Abstract Disclosure: K. Granados: None. A. Durán: F. Almaguel: D. De Leon: Our laboratory previously showed that Insulin-like growth factor II (IGF-II) promotes cell proliferation, inhibits apoptosis and induces chemoresistance of Breast Cancer (BC) cells. We demonstrated IGF-II achieves this by inhibiting pro-apoptotic proteins stimulating anti-apoptotic proteins. Those studies also prevented mitochondrial induced depolarization the membrane. Thus, regulates mitochondria to prevent death...