A5044354591- Helicobacter pylori-related gastroenterology studies
- Veterinary medicine and infectious diseases
- Radiation Effects and Dosimetry
- Viral gastroenteritis research and epidemiology
- Listeria monocytogenes in Food Safety
- Clostridium difficile and Clostridium perfringens research
- Photovoltaic Systems and Sustainability
- Salmonella and Campylobacter epidemiology
- Bacillus and Francisella bacterial research
- Microbial Inactivation Methods
- Phytochemistry and Bioactive Compounds
- Antimicrobial Resistance in Staphylococcus
- Microbial Metabolites in Food Biotechnology
- Enterobacteriaceae and Cronobacter Research
- Bioactive Compounds and Antitumor Agents
Instituto de Investigación Sanitaria Aragón
2021-2024
Universidad de Zaragoza
2019-2024
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology
2016-2020
Inactivated vaccines are commonly produced by incubating pathogens with chemicals such as formaldehyde or β-propiolactone. This is a time-consuming process, the inactivation efficiency displays high variability and extensive downstream procedures often required. Moreover, application of alters antigenic components viruses bacteria, resulting in reduced antibody specificity therefore stimulation less effective immune response. An alternative method for ionizing radiation. It acts very fast...
Antibiotic resistance is a major cause of the increasing failures in current eradication therapies against Helicobacter pylori. In this scenario, repurposing drugs could be valuable strategy to fast-track novel antimicrobial agents. present study, we analyzed inhibitory capability 1,4-dihydropyridine (DHP) antihypertensive on essential function H. pylori response regulator HsrA and investigated both vitro activities vivo efficacy DHP treatments Six different commercially available highly...
Ionizing radiation is widely used to inactivate pathogens. It mainly acts by destroying nucleic acids but causes less damage structural components like proteins. therefore highly suited for the sterilization of biological samples or generation inactivated vaccines. However, inactivation viruses bacteria requires relatively high doses and substantial amounts energy. Consequently, irradiation restricted shielded facilities-protecting personnel environment. We have previously shown that low...
is considered the most prevalent bacterial pathogen in humans. The increasing antibiotic resistance evolved by this microorganism has raised alarm bells worldwide due to significant reduction eradication rates of traditional standard therapies. A major challenge crisis identification novel microbial targets whose inhibitors can overcome currently circulating resistome. In present study, we have validated use essential response regulator ArsR as a and promising therapeutic target against
Bacterial pathogens cause severe infections worldwide in livestock and humans, antibiotic resistance further increases the importance of prophylactic vaccines. Inactivated bacterial vaccines (bacterins) are usually produced via incubation pathogen with chemicals such as formaldehyde, which is time consuming may loss immunogenicity due to modification structural components. We evaluated low-energy electron irradiation (LEEI) an alternative method generate a bacterin. Rodentibacter...
The increasing occurrence of multidrug-resistant strains the gastric carcinogenic bacterium
Helicobacter pylori infection constitutes a silent pandemic of global concern. In the last decades, alarming increase multidrug resistance evolved by this pathogen has led to marked drop in eradication rates traditional therapies worldwide, encouraging scientific community discover and develop new antimicrobial strategies. present work, we identified battery novel drug-like HsrA inhibitors with MIC values ranging from 0.031 4 mg/L against antibiotic-resistant strains H. pylori. Most these...
Helicobacter pylori infection constitutes a silent pandemic of global concern. In the last decades, alarming increase in multidrug resistance evolved by this pathogen has led to marked drop eradication rates traditional therapies worldwide. By using high-throughput screening strategy, combination with vitro DNA binding assays and antibacterial activity testing, we identified battery novel drug-like HsrA inhibitors MIC values ranging from 0.031 4 mg/L against several antibiotic-resistant...