A5076663213- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Primate Behavior and Ecology
- Viral Infections and Outbreaks Research
- Cytomegalovirus and herpesvirus research
- Aging, Elder Care, and Social Issues
- Agriculture and Rural Development Research
- Animal Disease Management and Epidemiology
- French Urban and Social Studies
- Animal Virus Infections Studies
- T-cell and Retrovirus Studies
- Poxvirus research and outbreaks
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Zoonotic diseases and public health
- Malaria Research and Control
- Rabies epidemiology and control
- Vector-Borne Animal Diseases
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
University of Zimbabwe
2022-2025
Université de Montpellier
2014-2025
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2016-2025
Institut de Recherche pour le Développement
2014-2025
Centre National de la Recherche Scientifique
2017-2025
Agropolis International
2003-2023
Inserm
1996-2020
Hôpital Militaire Moulay Ismail
2020
York District Hospital
2020
University of Zurich
2016
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired syndrome (AIDS), is a zoonotic infection staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The most closely related to HIV-1 simian (SIV) thus far identified only in captive members chimpanzee subspecies Pan troglodytes . Here we report detection SIVcpz antibodies nucleic acids fecal samples from wild-living P. t. apes southern Cameroon, where prevalence rates some...
Significance Understanding emerging disease origins is important to gauge future human infection risks. This particularly true for the various forms of AIDS virus, HIV-1, which were transmitted humans on four independent occasions. Previous studies identified chimpanzees in southern Cameroon as source pandemic M group, well geographically more restricted N group. Here, we show that remaining two groups also emerged but had their western lowland gorillas. Although group P has only been...
Abstract To assess human exposure to Simian immunodeficiency virus (SIV) in west central Africa, we looked for SIV infection 788 monkeys that were hunted the rainforests of Cameroon bushmeat or kept as pets. Serologic reactivity suggesting was found 13 16 primate species, including 4 not previously known harbor SIV. Overall, 131 sera (16.6%) reacted strongly and an additional 34 (4.3%) weakly with HIV antigens. Molecular analysis identified five new phylogenetic lineages. These data document...
Objective To study the feasibility, effectiveness, adherence, toxicity and viral resistance in an African government HAART initiative. Methods A prospective observational cohort started Dakar August 1998. Initial treatment consisted of two nucleoside reverse transcriptase inhibitors one protease inhibitor. The patients attended monthly medical examinations. Plasma HIV-1 RNA CD4 cell counts were determined at baseline every 6 months. Intention-to-treat analyses performed. Results Fifty-eight...
Chikungunya virus (CHIKV) is an emerging arbovirus of the Togaviridae family that poses a present worldwide threat to human in absence any licensed vaccine or antiviral treatment control viral infection. Here, we show compounds interfering with intracellular cholesterol transport have capacity inhibit CHIKV replication skin fibroblasts, major entry site host. Pretreatment these cells class II cationic amphiphilic compound U18666A, FDA-approved antidepressant drug imipramine resulted near...
A recommendation of: Malika Bouchez-Zacria, Clément Calenge, Alexandre Villers, Sylvie Lecollinet, Gaelle Gonzalez, Benoit Quintard, Antoine Leclerc, Florence Baurier, Marie-Claire Paty, Eva Faure, Cyril Eraud, Anouk Decors Relevance of the synergy surveillance and populational networks in understanding Usutu virus outbreak within common blackbirds (Turdus merula) Metropolitan France, 2018 https://doi.org/10.1101/2024.07.22.604715
ABSTRACT Most human immunodeficiency virus (HIV) drug susceptibility studies have involved subtype B strains. Little information on the impact of viral diversity natural to antiretroviral drugs has been reported. However, prevalence non-subtype-B (non-B) HIV type 1 (HIV-1) strains continues increase in industrialized countries, and treatments recently become available certain developing countries where non-B subtypes predominate. We sequenced protease reverse transcriptase (RT) genes 142...
To assess the prevalence of intestinal parasites in a cohort human immunodeficiency virus (HIV)-infected adults Cameroon, cross-sectional study was conducted. Detection performed 181 stool samples from 154 HIV-infected patients with mean CD4 cell count 238 cells/mm(3). Only 35 (22%) were receiving antiretroviral therapy at time sampling, and 46 (29%) had diarrhea. Opportunistic protozoa found 15 (9.7%), 8 whom (53%) Enterocytozoon bieneusi eight patients, C. parvum six Isospora belli three...
Chimpanzees and gorillas are the only nonhuman primates known to harbor viruses closely related HIV-1. Phylogenetic analyses showed that acquired simian immunodeficiency virus SIVgor from chimpanzees, SIVcpz/SIVgor lineage have been transmitted humans on at least four occasions, leading HIV-1 groups M, N, O, P. To determine geographic distribution, prevalence, species association of SIVgor, we conducted a comprehensive molecular epidemiological survey wild in Central Africa. Gorilla fecal...
Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family. Although infection with ZIKV generally leads to mild disease, its recent emergence in Americas has been associated increase development Guillain-Barré syndrome adults, as well neurological complications, particular congenital microcephaly, new-borns. To date, little information available on neuroinflammation induced by ZIKV, notably microglial cells context their metabolic activity, a series chemical transformations that...
While the world’s attention is focused on controlling COVID-19, evidence points at biodiversity crisis as a leading factor in its emergence, and outbreak of many past emerging infectious diseases. Agriculture major driver loss globally. Feeding growing human population ways that minimize harm to thus imperative prevent next COVID-19. Solutions exist, but burden implementing them should not be left farmers alone, who are mainly small-scale family farmers. Supportive policies markets needed,...
Non-syncytium-inducing (NSI) variants seem to be more readily transmitted than syncytium-inducing (SI) variants, and the switch from NSI SI during HIV-1 infection seems a key determinant evolution of AIDS. We investigated eventual differences in capacity on MT-2 cells according genetic subtypes correlated this observations with CD4 counts duration HIV infection. In total, 86 patients, most known date contamination infected different subtypes, have been studied: 11 subtype A, 46 B, 22 C, 7 E....
The genetic subtype was identified in gag and env of 219 HIV-1-positive samples collected different African countries, 44 from Senegal, 55 Cameroon, 82 Gabon, 38 Djibouti. In total, 20 (9.1%) had discordant subtypes between env, 6 (13.9%) 4 (7.2%) 1 (2.6%) Djibouti, 10 (12.1%) Gabon. Subtypes A G were predominantly involved the recombination events. Phylogenetic tree analysis showed that an important number sequences form a distinct subcluster with AG-IBNG prototype strain (a complex A/G...
ABSTRACT A Cameroonian patient with antibodies reacting simultaneously to human immunodeficiency virus type 1 (HIV-1) group O- and M-specific V3-loop peptides was identified. In order confirm that this coinfected both viruses, PCRs discriminating primers corresponding different regions of the genome were carried out primary lymphocyte DNA viral strains isolated from three consecutive samples. The PCR data suggested is a M recombinant M/O virus. Indeed, only gag sequences could be amplified,...
Objective: To identify the genetic subtypes and characteristics of HIV-1 strains from individuals infected after overseas deployment. Patients methods: Sixty-one HIV-1-positive detected between 1986 1995 in French army were included study. For each patient, year country HIV infection are known. Genetic determined using heteroduplex mobility assay (HMA) ED5/ED12 as outer ES7/ES8 inner primers. Strains further characterized by sequencing phylogenetic analysis C2-V3 region. The amino-acid...
Simian Immunodeficiency Viruses (SIVs) are the precursors of Human (HIVs) which have lead to worldwide HIV/AIDS pandemic. By studying SIVs in wild primates we can better understand circulation these viruses their natural hosts and habitat, perhaps identify factors that influence susceptibility transmission within between various host species. We investigated SIV status West African chimpanzees (Pan troglodytes verus) frequently hunt consume western red colobus monkey (Piliocolobus badius...
As antiretroviral treatment (ART) continues to expand in resource-limited countries, the emergence of HIV drug resistance mutations (DRMs) is challenging these settings. In Gabon (central Africa), no study has yet reported virological effectiveness initial ART given through routine care.Following World Health Organization (WHO) recommendations, a cross-sectional with one-time HIV-1 RNA viral load (VL) measurement was conducted assess failure (VF) defined by VL result ≥1000 copies/ml and DRMs...