A5073452598- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Retinoids in leukemia and cellular processes
- Multiple Myeloma Research and Treatments
Massachusetts Eye and Ear Infirmary
2020-2022
Smith-Kettlewell Eye Research Institute
2020-2022
Harvard University
2020-2022
Abstract Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment surgery failure. Despite significant advances in vitreoretinal surgery, it still remains without an effective prophylactic or therapeutic medical treatment. After ocular injury detachment, misplaced cells undergo epithelial to mesenchymal transition (EMT) form contractile membranes within eye. We identified Runt-related transcription factor 1 (RUNX1) as a gene highly expressed surgically-removed human...
To test the efficacy of runt-related transcription factor 1 (RUNX1) inhibition with topical nanoemulsion containing Ro5-3335 (eNano-Ro5) in experimental ocular neovascularization.Preclinical study.In vitro primary culture human retinal endothelial cell (HREC) culture. C57BL/6J 6- to 10-week-old male and female mice.We evaluated effect eNano-Ro5 proliferation, toxicity, migration HRECs. We used an alkali burn model corneal neovascularization a laser-induced choroidal vivo pathologic...