Background & aims Previous studies have examined the effects of metabolic syndrome (MetS) rather than its severity on race and ethnic disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). We used MetS score, a validated sex-race-ethnicity-specific measure, to examine race/ethnicity association between MASLD. Methods This study included 10,605 adult participants from Third National Health Nutrition Examination Survey. The MASLD diagnosis was based ultrasound...

INTRODUCTION: Acute pancreatitis (AP) occurs among patients with pancreas-sufficient cystic fibrosis (PS-CF) but is reportedly less common pancreas-insufficient (PI-CF). The incidence of AP may be influenced by transmembrane conductance regulator (CFTR) modulator use. We hypothesized that CFTR modulators would reduce hospitalizations, the greatest benefit in PS-CF. Methods: MarketScan (2012–2018) was queried for hospitalizations and use CF. Multivariable Poisson models enabled crossover...

ABSTRACT Despite advances in treatment for cystic fibrosis (CF), liver disease remains a major contributor to morbidity and mortality persons with CF. Therefore, transplantation may be considered end-stage CF-related disease. We present young patient CF who underwent solo has successfully restarted on elexacaftor/tezacaftor/ivacaftor without significant pulmonary or hepatic complications after transplant.

Previous studies have identified treatment disparities in the of hepatocellular carcinoma (HCC) based on insurance status and provider. Recent shown more Americans healthcare insurance; therefore we aim to determine if providers continue exist. A retrospective database analysis using NIS was performed between 2010 2013 including adult patients with a primary diagnosis HCC determined by ICD-9 codes. Multivariable logistic regressions were analyze differences treatment, mortality, features...

The success of direct-acting antivirals (DAA) has transformed the management hepatitis C virus (HCV) infection and led to expansion deceased donor organ pool for liver transplantation.We present a single center retrospective review transplantations performed on HCV-seronegative recipients from HCV-seropositive organs 11/2017 05/2020. HCV nucleic acid testing (NAT) was donors assess active infection.42 underwent transplant donor, including 21 NAT negative (20 liver, 1 simultaneous kidney...

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators significantly improve pulmonary function in patients with cystic (CF) but the effect on hepatobiliary outcomes remains unknown. We hypothesized that CF CFTR would have a decreased incidence of cirrhosis compared to not or ursodiol.To investigate development CF.A retrospective analysis was performed using Truven MarketScan from January 2012 through December 2017 including all diagnosis CF. Patients were excluded if they...

The Center for Medicare and Medicaid Services established 30-day readmission rate as a key metric in measuring high-value, cost-conscious care; therefore, our aim is to develop risk score ulcerative colitis (UC) patients undergoing colectomy or proctectomy.This study used data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) participant user file (2011-2015). Patients with UC proctectomy were identified using ICD-9, 10, CPT codes. Stepwise...

To determine if racial disparities continue to exist in the treatment of hepatocellular carcinoma (HCC).A retrospective database analysis using Nationwide Inpatient Sample was performed including patients with a primary diagnosis HCC. Univariate and multivariate analyses were utilized liver decompensation, treatment, inpatient mortality, metastatic disease.A total 62604 HCC included consisting 32428 Caucasian, 9726 African-American, 8988 Hispanic, 11462 other races. Caucasian more likely...

Abstract Background There is limited literature describing the real‐world practice of delayed initiation and shortened duration direct‐acting antiviral (DAA) in kidney transplant recipients. We compared Hepatitis C virus (HCV) cure rates among recipients who received an HCV nucleic acid test positive (NAT +) were treated with sofosbuvir/velpatasvir (SOF/VEL) for 12 weeks or glecaprevir/pibrentasvir (G/P) 8 weeks, a that 4 shorter than guideline recommendation treatment delay beyond 1‐week...

To evaluate disparities in the treatment of hepatocellular carcinoma (HCC) based on gender.A retrospective database analysis using Nationwide Inpatient Sample (NIS) was performed between 2010 and 2013. Adult patients with a primary diagnosis determined by International Classification Disease 9 (ICD-9) codes were included. Univariate multivariate logistic regressions to analyze differences treatment, mortality, features decompensation, metastatic disease patient's gender.The included 62582...

AIMTo determine the readmission rate, its reasons, predictors, and cost of 30-d in patients with cirrhosis ascites. METHODSA retrospective analysis nationwide database (NRD) was performed during calendar year 2013.All adults cirrhotics a diagnosis ascites,

Abstract Background and Aim Cirrhosis‐related complications are associated with high inpatient mortality, cost, length of stay. There is a lack multi‐centered studies on interventions for hepatic hydrothorax its impact patient outcomes. The aim this study was to determine the effect performing thoracentesis hospital stay, 30‐day readmission. Methods A retrospective analysis Nationwide Inpatient Sample between 2002 2013 Readmission Database during performed including patients primary...

OBJECTIVES: Performing a sigmoidoscopy or colonoscopy is recommended for assessment of disease activity, excluding infection, and guiding medical treatment during ulcerative colitis (UC)-related hospitalizations. However, it unknown whether the timing endoscopy impacts clinical outcomes. The objective our study was to determine impact on hospital outcomes in patients with UC-related METHODS: This cross-sectional using data from Nationwide Inpatient Sample database (2006–2013). Adult...

Psychosocial stressors related to the coronavirus-19 (COVID-19) pandemic increased alcohol consumption. The effect on patients with alcohol-related liver diseases remains unclear.Hospitalizations at a tertiary care center due disease from March 1 through August 31 in 2019 (pre-pandemic cohort) and 2020 (pandemic were reviewed retrospectively. Differences patient demographics, features, outcomes estimated alcoholic hepatitis utilizing T-tests, Mann-Whitney tests, Chi-square Fisher Exact Tests...

Given the increased rates of pregnancy in liver transplant recipients, evaluating safety is crucial. We aim to evaluate pregnancy-related complications and outcomes recipients.A retrospective nationwide review comparing recipients vs general population was performed between 2005 2013. Propensity-matched multivariable regression analyses were study pregnancy- delivery-related addition patient hospital outcomes.A total 38,449,030 admissions evaluated this including 1,469 (0.004%) recipients....

The coronavirus disease 2019 pandemic led to changes in individuals' behaviors and healthcare delivery. We examined the impact of these on rates clinical course acute pancreatitis (AP).Hospitalizations for AP from March 1 through August 31 (baseline group) same period 2020 (pandemic were retrospectively reviewed. Univariate multivariate analyses used demographics outcomes.Two hundred eighty subjects (315 admissions) identified 237 (264 2020. Subjects group more likely have systemic...

We sought to evaluate hospital outcomes of cirrhosis patients with nonvariceal upper gastrointestinal bleeding (NVUGIB).NVUGIB is common in cirrhosis. However, national outcome studies these are lacking.We utilized the 2014 Nationwide Readmission Database NVUGIB cirrhosis, further stratified as no (NC), compensated (CC), or decompensated (DC). Validated International Classification Diseases, Ninth Revision, Clinical Modification codes captured diagnoses and interventions. Outcomes included...

Liver involvement by acute leukaemia is rare and has a high mortality rate despite treatment. We report case of 66-year-old woman undergoing treatment for myelodysplastic syndrome with Vidaza (azacitidine) who presented abnormal liver function tests. Despite negative serologic testing unremarkable abdominal MRI, she continued to have significant elevation in bilirubin international normalised ratio worsening mental status. biopsy was obtained consistent myelogenous leukaemia. The patient had...

Accurate detection of gastric antral vascular ectasia (GAVE) is critical for proper management cirrhosis-related gastrointestinal bleeding. However, endoscopic diagnosis GAVE can be challenging when overlaps with severe portal hypertensive gastropathy (PHG).To determine the added diagnostic value virtual chromoendoscopy to high definition white light real-time and PHG.We developed an I-scan criteria PHG. We tested our in a cross-sectional cohort cirrhotic adults PHG high-definition endoscopy...

Significant elevations in alpha-fetoprotein should raise suspicion for hepatocellular carcinoma as malignancies with metastasis to the liver can elevate level but typically <300 ng/mL. Diagnosis be confirmed typical characteristics of on imaging and or biopsy confirm diagnosis.