A5037954223- Parkinson's Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Cell Adhesion Molecules Research
- Lysosomal Storage Disorders Research
- MicroRNA in disease regulation
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Autophagy in Disease and Therapy
- Cellular transport and secretion
Northwestern University
2021-2024
Loyola University Chicago
2019-2021
Numerous lines of evidence support the premise that misfolding and subsequent accumulation SNCA/α-synuclein (synuclein alpha) is responsible for underlying neuronal pathology observed in Parkinson disease (PD) other synucleinopathies. Moreover, cell-to-cell transfer these misfolded SNCA species thought to be progression spread cellular throughout brain. Previous work has shown when exogenous, fibrils enter cells through endocytosis, they can damage rupture membranes their endocytotic...
mutations that encode lysosomal β-glucocerebrosidase (GCase) cause the storage disorder Gaucher disease (GD) and are strong risk factors for synucleinopathies, including Parkinson's Lewy body dementia. Only a subset of subjects with
ABSTRACT Extracellular vesicles (EVs) have been implicated in a wide variety of biological activities, the pathogenesis numerous diseases, and proposed to serve as potential biomarkers disease human patients animal models. However, characterization EV populations is often performed using methods that do not account for heterogeneity require comparatively large sample sizes facilitate analysis. Here, we describe an imaging‐based method allows multiplexed at single level following...
The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in Parkinson's disease (PD) multiple system atrophy (MSA). While mouse can fibrillize vitro, whether these fibrils commonly used research to induce this or form reproduce structures the human brain remains unknown. Here, we report first atomic structure fibrils, which was solved parallel by two independent teams. shows striking similarity MSA-amplified PD-associated E46K fibrils. However, display altered...
Short Abstract The intricate process of α-synuclein aggregation and fibrillization hold pivotal roles in Parkinson’s disease (PD) multiple system atrophy (MSA). While mouse can fibrillize vitro , whether these fibrils commonly used research to induce this or form reproduce structures the human brain remains unknown. Here we report first atomic structure fibrils, which was solved parallel by two independent teams. shows striking similarity MSA-amplified PD-associated E46K fibrils. However,...
Abstract Extracellular vesicles (EVs) are implicated in a wide variety of biological activities, have been the pathogenesis numerous diseases, and proposed to serve as potential biomarkers disease human patients animal models. However, characterization EV populations is often performed using methods that do not account for heterogeneity require comparatively large sample sizes facilitate analysis. Here, we describe an imaging-based method allows multiplexed at single level following...