A5031009054- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical Chemistry and Chromatography
- Water Quality and Pollution Assessment
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Pesticide and Herbicide Environmental Studies
- Water Quality Monitoring and Analysis
- Water Treatment and Disinfection
- Analytical chemistry methods development
- Fish Ecology and Management Studies
- Groundwater and Isotope Geochemistry
- Lanthanide and Transition Metal Complexes
- Effects and risks of endocrine disrupting chemicals
- Heavy metals in environment
- Pesticide Residue Analysis and Safety
- MRI in cancer diagnosis
- Isotope Analysis in Ecology
- Water Quality and Resources Studies
- NMR spectroscopy and applications
- Acute Kidney Injury Research
- Advanced MRI Techniques and Applications
- Facial Rejuvenation and Surgery Techniques
KWR Water Research Institute
2019-2024
Radboud University Nijmegen
2022-2024
Radboud University Medical Center
2024
Radboud Institute for Molecular Life Sciences
2024
Leiden University Medical Center
2023
Vrije Universiteit Amsterdam
1995-2004
Royal Netherlands Institute for Sea Research
2001
Non-target screening (NTS) including suspect with high resolution mass spectrometry has already shown its feasibility in detecting and identifying emerging contaminants, which subsequently triggered exposure mitigating measures. NTS a large potential for tasks such as effective evaluation of regulations safe marketing substances products, prioritization monitoring programmes assessment environmental quality. To achieve this, further development methodology is required, including: (i)...
Abstract Gadolinium-based contrast agents (GBCA) are essential for diagnostic MRI examinations. GBCA only used in small quantities on a per-patient basis; however, the acquisition of contrast-enhanced examinations worldwide results use many thousands litres per year. Data shows that these present sewage water, surface and drinking water regions world. Therefore, there is growing concern regarding environmental impact because their ubiquitous presence aquatic environment. To address problem...
Abstract Background Prioritisation of chemical pollutants is a major challenge for environmental managers and decision-makers alike, which essential to help focus the limited resources available monitoring mitigation actions on most relevant chemicals. This study extends original NORMAN prioritisation scheme beyond target chemicals, presenting integration semi-quantitative data from retrospective suspect screening expansion existing exposure risk indicators. The utilises retrieved...
Abstract Biota to sediment accumulation factors (BSAFs) are widely used describe the potential of organic contaminants in organisms. From field studies it is known that these BSAFs can vary dramatically between sediments different origin, which possibly explained by variation bioavailability sediments. In present study shown variability BSAF values for samples obtained at two Dutch freshwater sites could largely be Tenax‐extractable concentrations Variations a factor about 50 explained. The...
Effect-directed analysis has been applied to a river sediment sample of concern identify the compounds responsible for observed effects in an vitro (anti-)androgenicity assay. For identification after non-target performed on high-resolution LTQ-Orbitrap, we developed de novo strategy including physico-chemical parameters derived from effect-directed approach. With this strategy, were able handle immense amount data produced by accurate mass analysis. The approach, together with led...
Objectives The aim of this study was to summarize the current preclinical and clinical evidence on association between exposure gadolinium (Gd) compounds skin toxicity in a setting similar practice. Materials Methods A search MEDLINE PubMed references from January 2000 December 2022 performed using keywords related deposition its effects skin, such as “gadolinium,” “gadolinium-based contrast agents,” “skin,” “deposition,” “toxicity.” In addition, cross-referencing added when appropriate. For...
Abstract The object of this study was to investigate the formation pyrene metabolites by isopod Porcellio scaber as a possible tool in environmental risk assessment polycyclic aromatic hydrocarbon (PAH) exposure terrestrial ecosystems. studied after either pulse single high dose, or prolonged (14 d) lower dosage. Exposure studies were carried out with unlabeled radiolabeled pyrene, ion pair chromatography used for analysis, and reference conjugates synthesized. We also measured field—exposed...
In the past decade during automated surface water monitoring in river Meuse at border station Eijsden The Netherlands, a set of unknown compounds were repeatedly detected by online liquid chromatography-diode-array detection relatively high signal intensity. Because nature compounds, consequently fate this mixture treatment processes, location being close to inlet drinking supply company and their possible adverse public health effects, it was deemed necessary elucidate identity compounds....
Abstract Improving river water quality requires a thorough understanding of the relationship between constituent concentration and discharge during runoff events (i.e., C‐Q hysteresis), which may be strongly non‐linear. Analysis hysteresis on large temporal scales provides unprecedented insights into event dynamics long‐term trends in surface groundwater. Despite increasing availability time series data quality, there are still limited quantitative modeling frameworks that enable this...
Abstract To safeguard the quality of river water, a comprehensive approach is required within European Water Framework Directive. It vital to conduct non-target screening complete chemical fingerprint aquatic ecosystem, as this will help identify chemicals emerging concern and uncover their unusual dynamic patterns in water. Achieving goal calls for an advanced combination two measurement paradigms: tracing potential pollution path through network detecting numerous compounds that constitute...
Abstract Polycyclic aromatic hydrocarbons (PAHs) are abundant pollutants, and many PAHs carcinogenic, but only after metabolic activation. Benzo[ a ]pyrene (B P) is among the most carcinogenic PAHs. The dose time response of two enzymes involved in B P metabolism amounts metabolites excreted into bile were evaluated an experiment with dab ( Limanda limandä ). Ninety exposed orally to one five doses (0, 0.08, 0.4, 2, or 10 mg/kg) sampled at 3, 6, 12 d exposure. None studied caused significant...
Abstract The 2000 European Union Water Framework Directive (WFD) states that “Member States shall ensure the necessary protection for bodies of water identified with aim avoiding deterioration in their quality order to reduce level purification treatment required production drinking water.” However, it does not specify how evaluate or quantify this treatment. We propose a novel index (WQI) prepare from source water. It is based on WQI Canadian Council Ministers Environment (CCME WQI). Our...
Abstract In this study, biotransformation products of pyrene were measured in the hepatopancreas terrestrial isopods as biomarkers polycyclic aromatic hydrocarbon (PAH) exposure. These products—pyrene‐1‐glucoside, pyrene‐1‐sulfate, an unknown conjugate, and 1‐hydroxypyrene—were quantitated using high‐performance liquid chromatography (HPLC) with fluorescence detection. a controlled exposure experiment, linear relationship was established between metabolite concentrations Porcellio scaber...
Little is known about the capacity of terrestrial invertebrates to transform organic soil pollutants such as polycyclic aromatic hydrocarbons (PAHs). Studies were designed characterize microsomal mixed function oxygenase and accompanying conjugation enzymes from hepatopancreas isopods Porcellio scaber Oniscus asellus using pyrene 1-hydroxypyrene model substrates. The hydroxylation formation pyreneglucoside pyrenesulfate appeared be sensitive measures for activity cytochrome P450 aryl...
Abstract The European Water Framework Directive (WFD) states that measures should be taken to improve the quality of water bodies prevent further required extension current (drinking) treatment. Hence, for managers it is key importance evaluate and report on level purification treatment required. For this purpose a novel framework indices defined, their definition allows inclusion new, emerging substances. can calculated based micropollutant characteristics alone do not require any knowledge...