A5005150614- Effects and risks of endocrine disrupting chemicals
- Pharmaceutical and Antibiotic Environmental Impacts
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Reproductive biology and impacts on aquatic species
- Hormonal and reproductive studies
- Toxic Organic Pollutants Impact
- Isotope Analysis in Ecology
- Mass Spectrometry Techniques and Applications
- Chemical Analysis and Environmental Impact
- Water Quality Monitoring and Analysis
- Environmental Toxicology and Ecotoxicology
- Pluripotent Stem Cells Research
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Microplastics and Plastic Pollution
- Vitamin C and Antioxidants Research
- Gene expression and cancer classification
- bioluminescence and chemiluminescence research
- Innovation Policy and R&D
- Pesticide Residue Analysis and Safety
- Marine Biology and Environmental Chemistry
Joint Research Centre
2019
BioDetection Systems (Netherlands)
2008-2014
KWR Water Research Institute
2010
University of Amsterdam
2010
Wageningen University & Research
2003
Thousands of organic micropollutants and their transformation products occur in water. Although often present at low concentrations, individual compounds contribute to mixture effects. Cell-based bioassays that target health-relevant biological endpoints may therefore complement chemical analysis for water quality assessment. The objective this study was evaluate cell-based suitability benchmark assess efficacy treatment processes. selected cover relevant steps the toxicity pathways...
It is generally known that there are compounds present in the aquatic environment can disturb endocrine processes, for example via interaction with endogenous hormone receptors. Most research so far has focused on bind to estrogen and/or androgen receptor, but ligands other receptors might also be present. In this study, a newly completed panel of human cell derived CALUX reporter gene bioassays was utilized test water extracts (ER), as well (AR), progesterone (PR), and glucocorticoid (GR)...
In the past two decades much research effort has focused on occurrence, effects, and risks of estrogenic compounds. However, increasing emissions new emerging compounds may also affect action hormonal pathways other than axis. Recently, a suite novel CALUX bioassays become available that enables looking further effects only. By employing these bioassays, we recently showed high glucocorticogenic activity in wastewaters collected at various sites The Netherlands. since provide an integrated...
Effect-directed analysis has been applied to a river sediment sample of concern identify the compounds responsible for observed effects in an vitro (anti-)androgenicity assay. For identification after non-target performed on high-resolution LTQ-Orbitrap, we developed de novo strategy including physico-chemical parameters derived from effect-directed approach. With this strategy, were able handle immense amount data produced by accurate mass analysis. The approach, together with led...