A5102851106- Occupational and environmental lung diseases
- Pharmaceutical and Antibiotic Environmental Impacts
- Carcinogens and Genotoxicity Assessment
- Environmental Toxicology and Ecotoxicology
- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Arsenic contamination and mitigation
- Water Quality Monitoring and Analysis
- Air Quality and Health Impacts
- Advanced oxidation water treatment
- Water Treatment and Disinfection
- Nanoparticles: synthesis and applications
- Analytical chemistry methods development
- Retinoids in leukemia and cellular processes
- Marine Biology and Environmental Chemistry
- Trace Elements in Health
- Phytoestrogen effects and research
- Toxic Organic Pollutants Impact
- Radioactivity and Radon Measurements
- Microplastics and Plastic Pollution
- Energy and Environment Impacts
- Wastewater Treatment and Nitrogen Removal
- Recycling and Waste Management Techniques
- Protein Hydrolysis and Bioactive Peptides
- bioluminescence and chemiluminescence research
IWW Water Centre
2011-2023
University of Duisburg-Essen
2008-2023
Essen University Hospital
2004-2013
Institute of Medical Microbiology and Hygiene
2005-2012
In-Q-Tel
2009
Institut für Hygiene und Umwelt
2004
University of Rostock
1995-2002
Indian Institute of Toxicology Research
2002
Thousands of organic micropollutants and their transformation products occur in water. Although often present at low concentrations, individual compounds contribute to mixture effects. Cell-based bioassays that target health-relevant biological endpoints may therefore complement chemical analysis for water quality assessment. The objective this study was evaluate cell-based suitability benchmark assess efficacy treatment processes. selected cover relevant steps the toxicity pathways...
Inhaled ultrafine titanium dioxide (UF-TiO2) particles cause pronounced pulmonary inflammation, in contrast to fine TiO2. Previous studies provide evidence for the production of reactive oxygen species by alveolar macrophages, after overloading with UF-TiO2 and cytotoxicity rat lung macrophages. also causes fibrosis tumors rats. are photogenotoxic, but general, information on genotoxicity is still limited. We studied potential (particle size less than or equal 20 nm) TiO2 > 200 induce...
Abstract Titanium dioxide (TiO 2 ), also known as titanium (IV) oxide or anatase, is the naturally occurring of titanium. It one most commercially used form. To date, no parameter has been set for average ambient air concentration TiO nanoparticles (NP) by any regulatory agency. Previously conducted studies had established these to be mainly non-cyto- and -genotoxic, although they found generate free radicals both acellularly (specially through photocatalytic activity) intracellularly. The...
Mammals are able to convert inorganic arsenic mono-, di-, and trimethylated metabolites. In previous studies we have shown that the trivalent organoarsenic compounds more toxic than their counterparts toxicity is associated with cellular uptake of arsenicals. present study, investigated cyto-/genotoxic effects arsenate [Asi(V)], arsenite [Asi(III)], monomethylarsonic acid [MMA(V)], monomethylarsonous [MMA(III)], dimethylarsinic [DMA(V)], dimethylarsinous [DMA(III)], trimethylarsine oxide...
Nanomaterials are extensively used in industry and daily life, but little is known about possible health effects. An intensified research regarding toxicity of nanomaterials urgently needed. Several studies have demonstrated that nanoparticles (NPs; diameter < 100 nm) can be transported to the central nervous system; however, interference NPs with electrical activity neurons has not yet been shown.We investigated acute electrophysiological effects carbon black (CB), hematite (Fe2O3),...
Epidemiological studies have indicated that exposure of humans to inorganic arsenic in drinking water is associated with the occurrence bladder cancer. The mechanisms by which induces this malignancy are still uncertain; however, metabolites suspected play a pivotal role. aim present study was investigation uptake capabilities human urothelial cells (UROtsa) compared primary hepatocytes (phH) as well intracellular distribution species. Additionally, we were interested cyto- and genotoxic...
The specific properties of nanoscale particles, large surface-to-mass ratios and highly reactive surfaces, have increased their commercial application in many fields. However, the same are also important for interaction bioaccumulation nonbiodegradable particles a biological system cause concern. Hematite (α-Fe2O3), being mineral form Fe(III) oxide, is one most used iron oxides besides magnetite. aim our study was characterization comparison biophysical reactivity toxicological effects...
ABSTRACT Effluents from municipal wastewater treatment plants (WWTPs) are known to be point sources of micropollutants for surface waters. The aim this study was examine a reconstructed full-scale ozonation equipped with pump-injector system ozone (O3) dosage and fluidized moving-bed reactor as biological posttreatment at WWTP utilizing an effect-directed approach. This approach consists chemical analysis in combination toxicological tests the assessment efficiency plant. Chemical showed...
Nineteen specimens from primary human malignant mesotheliomas obtained 19 patients were screened for activating point mutations in the oncogenes N-ras and CDK4 by combined RFLP-PCR/SSCP analysis. In addition, all tumours deletions tumour suppressor genes p53, p16INK4a (CDKN2A) p14ARF (exon-1beta) multiplex-PCR/SSCP No found N-ras, p53 CDK4. Three displayed homozygous deletion (co-deletion of exons 1, 2 3) p16INK4a. One them additional (exon-1beta). Two silent polymorphisms 3 tumours. Our...
Asbestos and other mineral fibers have long been known to induce lung cancer mesothelioma. However, the primary mechanisms of fiber-induced carcinogenesis still remain unclear. We investigated occurrence mitotic disturbances induced by asbestos (amosite, crocidolite, chrysotile) in an vitro approach using Syrian hamster embryo (SHE) fibroblast cells. The following endpoints were investigated: micronucleus formation as a result characterization population kinetochore staining visualization...
Bismuth compounds are widely used in industrial processes and products. In medicine, bismuth salts have been applied combination with antibiotics for the treatment of Helicobacter pylori infections, prevention diarrhea, radioimmunotherapy. environment, ions can be biotransformed to volatile compound trimethylbismuth (Me3Bi) by methanobacteria. Preliminary in-house studies indicated that methylated human colon intestinal microflora following ingestion bismuth-containing salts. Information...
The broad use of plastics and the persistence material results in plastic residues being found practically everywhere environment. If remain (aquatic) environment, natural weathering leads to degradation processes compounds may leach from into To investigate impact process on toxicity leachates, different types UV irradiation (UV-C, UV-A/B) were used simulate containing virgin as well recyclate biodegradable polymers. leached substances investigated toxicologically using in-vitro bioassays....
Asbestos is a known carcinogen and co-carcinogen. It persisting risk in our daily life due to its use building material as asbestos-cement powder. The present study done on V79-cells (Chinese hamster lung cells) demonstrates the cytotoxic genotoxic potential of powder (ACP) comparison with chrysotile asbestos. A co-exposure ACP was tested using cell viability test micronucleus assay. kinetochore analysis had been used analyse pathway causing such effects. Thiobarbituric acid-reactive...