A5032684918- Computational Drug Discovery Methods
- Carcinogens and Genotoxicity Assessment
- Tuberculosis Research and Epidemiology
- Nanoparticles: synthesis and applications
- Air Quality and Health Impacts
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Occupational and environmental lung diseases
- Arsenic contamination and mitigation
- RNA modifications and cancer
- vaccines and immunoinformatics approaches
- Pharmacogenetics and Drug Metabolism
- Pesticide Exposure and Toxicity
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Fullerene Chemistry and Applications
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Systemic Lupus Erythematosus Research
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Heavy Metal Exposure and Toxicity
- Free Radicals and Antioxidants
- SARS-CoV-2 and COVID-19 Research
- Cancer-related Molecular Pathways
Jazan University
2016-2024
Saudi Aramco Medical Services Organization
2021
Integral University
2010-2019
King George's Medical University
2017
University of Lucknow
2015
Govind Ballabh Pant University of Agriculture and Technology
2010
Indian Institute of Toxicology Research
1999-2004
Inhaled ultrafine titanium dioxide (UF-TiO2) particles cause pronounced pulmonary inflammation, in contrast to fine TiO2. Previous studies provide evidence for the production of reactive oxygen species by alveolar macrophages, after overloading with UF-TiO2 and cytotoxicity rat lung macrophages. also causes fibrosis tumors rats. are photogenotoxic, but general, information on genotoxicity is still limited. We studied potential (particle size less than or equal 20 nm) TiO2 > 200 induce...
Multi-walled carbon-nanotubes (MWCNTs)-induced apoptotic changes were studied in human lung epithelium cell line-A549. Non-cytotoxic doses of MWCNTs identified using tetrazolium bromide salt (MTT) and lactate dehydrogenase (LDH) release assays. Cells exposed to (0.5–100 μg/ml) for 6–72 h. Internalization characterization CNTs was performed by electron microscopy. Apoptotic estimated nuclear condensation, DNA laddering, confirmed expression associated markers: p53, p21WAF1/CIP1, Bax, Bcl2...
The increased inhaled application of titanium dioxide nanoparticles (TiO(2) NPs) increases the potential pulmonary health risks. present investigations were carried out to study TiO(2) NPs-induced apoptosis, oxidative stress and genotoxicity in human lung cancer cell line, A549, a widely used system for toxicity studies. Tetrazolium bromide salt lactate dehydrogenase release assays cytotoxicity. studies using cytokinesis block micronucleus assay. Apoptosis was confirmed by formation...
Bacterial resistance is a serious threat to human health. The production of β-lactamase, which inactivates β-lactams most common cause the β-lactam antibiotics. Class A enzymes are frequently encountered among four β-lactamases in clinic isolates. Mutations class play crucial role substrate and inhibitor specificity. SHV TEM type known be β-lactamases. In present study, we have analyzed effect resistant S130G point mutation Class-A β-lactamase using molecular dynamics other silico...
Caspase-3 has been identified as a key mediator of neuronal apoptosis. The present study identifies caspase-3 common player involved in the regulation multineurodegenerative disorders, namely, Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), and amyotrophic lateral sclerosis (ALS). protein interaction network prepared using STRING database provides strong evidence interactions with metabolic cascade said thus characterizing it potential therapeutic target for multiple...
Pulp and paper mill effluent induced phytotoxicity genotoxicity in mung bean ( Vigna radiata L.) root tip cells of onion Allium cepa were investigated. Physicochemical characteristics such as electrical conductivity (EC), biological oxygen demand (BOD 5 ), chemical (COD), total phenols the pulp beyond permissible limit specified for discharge inland water bodies. Compared to control plants, seedling exposed 100% concentration showed a reduction shoot length biomass by 65%, 67%, 84%,...
Introduction Hydrogen peroxide plays a crucial role in melanogenesis by regulating tyrosinase activity, the key melanin-forming enzyme responsible for browning of fruits, vegetables, and seafood. The need effective solutions to mitigate such processes highlights significance developing advanced catalytic agents. Methods We synthesized highly FeSe 2 nanospheres using one-step solvothermal process. were characterized through transmission electron microscopy (TEM), energy-dispersive X-ray...
This review examines Diabetic Peripheral Neuropathy (DPN), a significant complication of diabetes affecting nearly half diabetic patients. DPN is crucial to understand due its high prevalence and profound impact on patients’ quality life, causing pain, sensory loss, motor dysfunction, heightened risks foot ulcers amputations. As leading cause disability, grasping DPN’s pathophysiology, early diagnosis, treatment options are essential for alleviating burden. Key facets include complex...
Prediction of essential proteins a pathogenic organism is the key for potential drug target identification, because inhibition these would be fatal pathogen. Identification requires use complex experimental techniques which are quite expensive and time consuming. We implemented Support Vector Machine algorithm to develop classifier model in silico prediction prokaryotic based on physico-chemical properties amino acid sequences. This was designed set 10 descriptor vectors (DVs) 4 hybrid DVs...
BackgroundBasic Life Support [BLS; including cardiopulmonary resuscitation (CPR)] is a part of medical skills utilized in case an emergency care to save human lives. It well established that the young students can become major healthcare supportive workforce for community cases emergency. Therefore, adequate knowledge BLS necessary all university attending students. This study evaluated awareness and attitude towards training among Jazan University, Saudi Arabia.MethodsA self-administered...
Polycyclic aromatic hydrocarbons (PAH), like Benzo[alpha]Pyrene (BaP) are known to cause a number of toxic manifestations including lung cancer. As Titanium dioxide Nanoparticles (TiO2 NPs) have recently been shown adsorb PAHs from soil and water, we investigated whether TiO2 NPs could provide protection against the BaP induced toxicity in biological system. A549 cells when co-exposed with (25 µM, 50 µM 75 µM) along 0.1 µg/ml,0.5 µg/ml 1 NPs, showed significant reduction effects BaP, as...
The present investigations correlate the potentials of reactive oxygen species (ROS) generation and cyto-genotoxicity amphibole asbestos fibers (amosite, crocidolite tremolite) with their surface iron, under in vitro controlled conditions, using A549 cells (human lung epithelial cell line). mobilizable iron was measured by Atomic Absorption Spectroscopy; production ROS investigated 2, 7 dichloro-dihydrofluorescein-diacetate (DCFH-DA) dye; for cytotoxicity assessment, intracellular organelles...
We study the ameliorative potential of dimetylthiourea (DMTU), an OH• radical trapper and N-acetylcysteine (NAC), a glutathione precursor/H2O2 scavenger against titanium dioxide nanoparticles (TiO2-NPs) multi-walled carbon nanotubes (MWCNTs) induced cyto-genotoxicity in cultured human lung cancer cells-A549. Cytogenotoxicity was by exposing cells to selected concentrations (10 50 µg/ml) either TiO2-NPs or MWCNTs for 24 h. Anti-cytogenotoxicity effects DMTU NAC were studied two groups, i.e.,...
Currently available COVID vaccines are effective in reducing mortality and severity but do not prevent transmission of the virus or reinfection by emerging SARS-CoV-2 variants. There is an obvious need for better longer-lasting various prevailing strains evolving virus, necessitating development a broad-spectrum vaccine that can be used to infection both rate re-infection. During initial phases infection, nucleocapsid (N) protein one most abundantly expressed proteins. Additionally, it has...