A5031089922- Mitochondrial Function and Pathology
- Carcinogens and Genotoxicity Assessment
- Retinal Diseases and Treatments
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- GABA and Rice Research
- Effects of Radiation Exposure
- Plant Genetic and Mutation Studies
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolism and Genetic Disorders
- Bamboo properties and applications
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Craniofacial Disorders and Treatments
- Head and Neck Cancer Studies
- Diet, Metabolism, and Disease
- dental development and anomalies
- Inflammasome and immune disorders
- Endometriosis Research and Treatment
- Advanced Glycation End Products research
- Cleft Lip and Palate Research
- Heavy Metal Exposure and Toxicity
- Glutathione Transferases and Polymorphisms
Nirma University
2016-2021
King George's Medical University
2019-2020
Dr. Ram Manohar Lohia Institute of Medical Sciences
2014-2018
Indian Institute of Toxicology Research
2009-2014
Wayne State University
2011-2013
Kresge Eye Institute
2013
Council of Scientific and Industrial Research
2010
Diabetic retinopathy fails to halt after cessation of hyperglycemic insult, and a vicious cycle mitochondria damage continues. The aim our study was investigate the effect termination hyperglycemia on retinal mtDNA replication, elucidate mechanism responsible for continued damage.Polymerase gamma 1 (POLG1), catalytic subunit mitochondrial DNA replication enzyme, displacement loop region (D-loop) were analyzed in retina from streptozotocin-diabetic rats maintained poor glycemic control (PC,...
Aim: In the pathogenesis of diabetic retinopathy, retinal mitochondria are damaged, superoxide levels elevated, and mitochondrial DNA (mtDNA) biogenesis is impaired. mtDNA has a noncoding region, displacement loop (D-loop), which essential transcription replication elements, this region highly vulnerable to oxidative damage. The aim study investigate effect diabetes on D-loop damage machinery. Results: Using retina from wild-type (WT) dismutase transgenic (Tg) mice, we have investigated...
Promoter methylation and relative gene expression of O 6 -methyguanine-DNA-methyltransferase ( MGMT ) p16 genes were examined in tissue blood samples patients with premalignant oral lesions (PMOLs) squamous cell carcinoma (OSCC). Methylation-specific PCR reverse transcriptase performed 146 from controls PMOLs OSCC. In PMOL group, significant promoter was observed 59% (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract To evaluate the effect of pre‐ or posttreatment selenium (6 μmol/kg b.w., single intraperitoneal injection) in mercury intoxication, rats were exposed to (12 injection). Exposure resulted induced oxidative stress liver, kidney, and brain tissues. Marked changes serum biochemical parameters together with alterations histopathology an induction metallothionein‐I metallothionein‐II mRNA expression liver kidney observed. Pretreatment mercury‐exposed animals had protective on whereas...
Background: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among males in India. While tobacco and alcohol are main aetiological factors, human papilloma virus (HPV) presence has surprisingly increased head neck Squamous Cell Carcinoma (HNSCC) past two decade but its frequency OSCCS still uncertain. We aim to explore of HPV major genotypes North Indian patients their association with clinicopathological histopathological features p16 expression pattern. Materials...
Mitochondrial dysfunction is considered to play an important role in the development of diabetic retinopathy. Recent evidence has also shown many similarities between retinopathy and a low grade chronic inflammatory disease. The aim this study understand interrelationship proinflammtory mediator, IL-1β mitochondrial accelerated loss capillary cells retina. Using receptor gene knockout (IL-1R1−/−) mice, we have investigated effect regulation on mtDNA damage, increased retinal cell apoptosis...
The present study explores expression of NOS and pro-inflammatory cytokines, catalysis NO mediated modulation oxidative response apoptosis in neutrophils from spontaneously hypertensive rats (SHR). Neutrophils SHR showed ∼3-fold increments iNOS expression, 1.5-fold nOS calcium independent catalysis, whereas GTPCH was unaltered. Although phagocytic potential comparable, demonstrated augmented burst, which reduced by inhibition or the presence scavenger. also exhibited enhanced MPO [Ca2+]i...
Diagnostic and therapeutic radiation fields are planned so as to reduce side-effects while maximising the dose site but effects on healthy tissues inevitable. Radiation causes strand breaks in DNA of exposed cells which can lead chromosomal aberrations cause malfunction cell death. Several researchers have highlighted damaging high still there is a lacuna identifying damage due low used for diagnostic purposes. Blood an easy resource study genotoxicity estimate radiation. The micronucleus...
The ionizing radiation is a known carcinogen as well cancer therapeutic agent however, the side effect on normal tissue limiting factor and inadequate doses necessitates search for an ideal radioprotective agent. Bamboo species are rich source of antioxidants hence have value in many free radical mediated diseases. This first report regarding vitro protective bamboo leaf extract against induced genetic damage human peripheral blood lymphocytes by cytokinesis blocked micronuclei (CBMN) assay....