A5002328851- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Malaria Research and Control
- Sarcoma Diagnosis and Treatment
- Child Nutrition and Water Access
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Mosquito-borne diseases and control
- Testicular diseases and treatments
- Parasites and Host Interactions
- Palliative Care and End-of-Life Issues
- Bone and Joint Diseases
- Neutropenia and Cancer Infections
- Infant Development and Preterm Care
- Tumors and Oncological Cases
- Misinformation and Its Impacts
- Bladder and Urothelial Cancer Treatments
- CAR-T cell therapy research
- Social Media in Health Education
- Prenatal Screening and Diagnostics
- Gestational Trophoblastic Disease Studies
- Blood donation and transfusion practices
- Digital Imaging for Blood Diseases
- Epigenetics and DNA Methylation
Ahmadu Bello University Teaching Hospital
2016-2024
Ahmadu Bello University
2016-2024
The clinical severity of sickle cell disease (SCD) is strongly influenced by the level fetal haemoglobin (HbF) persistent in each patient. Three major HbF loci (BCL11A, HBS1L-MYB, and Xmn1-HBG2) have been reported, but a considerable hidden heritability remains. We conducted genome-wide association study for levels 1006 Nigerian patients with SCD (HbSS/HbSβ0), followed replication meta-analysis exercise four independent cohorts (3,582 patients). To dissect signals at loci, we performed...
Background: Malnutrition affects many children in Africa predisposing them to infection especially bacterial. Although malnutrition is highly prevalent among Nigerian little known about bacterial which believed adversely affect their outcome. Materials and Methods: This was a cross-sectional study. Ninety febrile with severe Protein Energy aged 6–59-month based on modified wellcome classification were enrolled as individuals and; 90 well-nourished age- sex-matched controls. It conducted at...
Background: Childhood malignancies are associated with high mortality. Although prognosis and outcomes have improved significantly in developed countries, mortality is still very resource-poor settings. Objectives: This study aimed at determining the patterns of childhood cancers over an 8-year period a tertiary center developing country. Materials Methods: A retrospective case notes children admitted for cancer between January 2006 December 2013. Results: Four hundred twenty-six all...
Background: Sickle cell anemia (SCA) is the most common and severest form of sickle disease. It affects about 3% Nigerian population with a high mortality in children. Hematological parameters are routinely used monitoring SCA patients might vary crisis steady states. Aims Objectives: This study was aimed at comparing hematological state those hemolytic vaso-occlusive Methodology: cross-sectional carried out pediatric outpatient clinic tertiary hospital North West Nigeria. We recruited 170...
Background: Malnutrition and malaria are common in sub-Saharan Africa, understanding the relationship between protein-energy malnutrition (PEM) is of great public health importance. Findings from studies evaluating associations various forms have been contradictory. This study aimed to determine prevalence parasitemia among malnourished children its determinants studied. Materials Methods: was a cross-sectional study. Ninety febrile with severe PEM aged 6–59 months (44 males 46 females)...
Background. Asymptomatic malaria parasitaemia has been documented in donor blood West Africa. However, donated is not routinely screened for parasites (MPs). The present study therefore aimed to document the frequency of transfusion-induced donor-recipient patterns, children receiving transfusion a tertiary health-centre. Methodology. A cross-sectional, observational involving 140 was carried out. Blood units and patients’ samples were obtained, determination Giemsa staining technique used...
Introduction: Sickle cell disease (SCD) is the most common hereditary hematological disorder in Nigeria with an annual incidence of more than 100,000 new births which contributes to high Nigerian under-five childhood morbidity and mortality. Sufferers are frequently admitted into emergency rooms for presentations complications such as pain crisis, anemia, stroke, acute chest syndrome, addition other infections severe malaria, sepsis, respiratory tract infections. The aim study was describe...
Abstract Background The clinical severity of sickle cell disease (SCD) is strongly influenced by the level fetal haemoglobin (HbF) persistent in each patient. Three major HbF loci ( BCL11A , HBS1L-MYB and Xmn1-HBG2 ) have been reported, but a considerable hidden heritability remains. Aim Building on power large genetically diverse patient pool present Nigeria, we conducted genome-wide association study for levels patients from three regions country with ethnic make-up. Methods We analysed...
Background: Although hydroxycarbamide (hydroxyurea [HU]) has been in use for decades both adults and child populations with sickle cell disease (SCD), its reported remained low Africa Nigeria where the largest number of SCD patients reside. Availability, cost, concerns about safety efficacy are some challenges to use. Objectives: This study highlights experience using HU children anemia Ahmadu Bello University Teaching Hospital, Zaria. Materials Methods: A descriptive, retrospective...
Malignancies have been reported to occur in people with sickle cell disease. Renal medullary carcinoma (RMC), also tagged seventh nephropathy, is an aggressive cancer seen almost exclusively disease more than 160 cases worldwide, but only few were patients anaemia (HBSS) and from Nigeria. Sarcomatoid renal a tumour of any histologic variant containing foci high-grade malignant spindle cells. We report adolescent girl who presented left tumour, histology which confirmed diagnosis sarcomatoid...
Context: Stroke is a devastating complication of sickle cell anemia (SCA) and fatal in about 5% patients, with chronic sequelae survivors. The occurrence stroke predictable preventable. However, up to 50% children some low-income settings are deprived optimal care.Aims: study aimed document the presentations interventions utilized.Settings Design: A descriptive, retrospective review was conducted.Materials Methods: Case records were manually retrieved patients managed for from April 2011...
Context Acute leukemia (AL) is the commonest hematological malignancy in childhood. The cause largely multifactorial and unknown, with exogenous endogenous factors interacting genetic susceptibility. Its incidence on rise globally including developing countries like Nigeria. Although prognosis developed has improved, poor outcomes are still norm resource-poor areas. Aims This review was undertaken to document sociodemographic characteristics, management challenges, of an African tertiary...
When patients are tethered with uncontrolled pain, health care practitioners usually resort to several modes of symptomatic relief for their patients.In palliative the goal is identifying and managing cause pain in addition addressing associated problems.To administer effective symptom control patient chronic non-cancer healthcare professionals may need consider alternative non-pharmacological treatment such as psychological intervention.Pain perception can be influenced by non-organic...
Background: Giant congenital melanocytic nevus is defined as a lesion present at birth that reaches diameter of more than 20 cm in adulthood. Its incidence estimated below 1:500,000 newborns. These lesions have major psychosocial impact on the patient and family because its unsightly appearance addition to neurological complications high risk malignant transformation into melanoma. Case: A 6-month-old girl presented with hyperpigmented skin over back, gluteal regions, perineum, thighs, scalp...
Sarcoma botryoides is a rare histological variant of rhabdomyosarcoma (RMS) found in the mucosal lining body cavities bladder, vagina, nasopharynx, and biliary tract. Vaginal RMS typically affects young girls below 2 years age but has also been reported adolescents. Most patients present late when tumor already caused significant regional effects complications. The management such children usually poses numerous challenges resource-poor setting. A 3-year-old girl presented with 1-year...
Introduction: The arrival of a newborn brings mixture excitement and anxiety, due to wide variation in physical physiologic findings. Neonatal morbidity mortality remain alarmingly high North-western Nigeria, failure recognize sick neonate that needs medical attention contributes these dire statistics. Therefore, an understanding the variations parameters allows health-care personnel address families' concerns support parents. Materials Methods: study was retrospective descriptive review...
Context: The novel coronavirus disease 2019 (COVID-19) pandemic brought about public health safety measures of social distancing and avoidance crowded gatherings. These led to widespread disruptions in activities daily living, as well routine health-care services learning activities. There has been a noticeable move the online domain platform for teaching learning. Aims: present study aimed describe experiences postgraduate medical doctors Nigerian hospitals. Subjects Methods: was...