A5062103826- Bone Metabolism and Diseases
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Vasculitis and related conditions
- Bone health and treatments
- Pharmacological Effects and Toxicity Studies
- Cholesterol and Lipid Metabolism
- Phytochemistry and Biological Activities
- Bone health and osteoporosis research
- Phytochemicals and Antioxidant Activities
- Retinoids in leukemia and cellular processes
- Urticaria and Related Conditions
- Hops Chemistry and Applications
- Drug-Induced Hepatotoxicity and Protection
- Chemotherapy-induced organ toxicity mitigation
- Vitamin K Research Studies
- HIV/AIDS drug development and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Natural Antidiabetic Agents Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Liver Disease Diagnosis and Treatment
- Mangiferin and Mango Extracts
- Rheumatoid Arthritis Research and Therapies
- HIV-related health complications and treatments
- Hormonal and reproductive studies
Wroclaw Medical University
2015-2024
University of Wrocław
2013
Szpital Kliniczny Nr 1 we Wrocławiu
2010
Background. Cornelian cherry (Cornus mas L.) is a plant growing in southeast Europe, the past used folk medicine. There are many previous publications showing preventive effects of (poly)phenolic compounds, especially anthocyanins, on cardiovascular diseases, but there lack studies comparing (poly)phenolics and other constituents fruits.Objectives. We have attempted to determine if iridoids anthocyanins from cornelian fruits may affect formation atherosclerotic plaques aorta as well lipid...
Cornelian cherry (Cornus mas L.) fruits possess potential cardiovascular, lipid-lowering and hypoglycemic bioactivities. The aim of this study is to evaluate the influence resin-purified cornelian extract rich in iridoids anthocyanins on several transcription factors, intima/media ratio aorta serum parameters, which determine or are valuable indicators adverse changes observed course atherosclerosis, cardiovascular disease, metabolic syndrome. For purpose, male New Zealand rabbits were fed a...
Atherogenesis leads to the development of atherosclerosis, a progressive chronic disease characterized by subendothelial lipoprotein retention and endothelial impairment in arterial wall. It develops mainly as result inflammation also many other complex processes, which arise from, among others, oxidation adhesion. Cornelian cherry (Cornus mas L.) fruits are abundant iridoids anthocyanins-compounds with potent antioxidant anti-inflammatory activity. This study aimed determine effect two...
Stress and everyday problems may impact memory cognition. Therefore, many people use cognitive enhancers (CEs), sold for prescription, as over-the-counter drugs, or dietary supplements, believing they help with functioning. Our study was designed to answer whether taking CEs is common among Medical University students identify which substances are mainly used.An anonymous online questionnaire answered by 479 of (88%) Dentistry (12%) Faculties in Poland. Women constituted the majority...
Background and Aims. Inflammatory bowel disease pharmacotherapy, despite substantial progress, is still not satisfactory for both patients clinicians. In view of the chronic relapsing course always effective treatment with adverse effects, attempts to search new, more efficient, safer substances are essential reasonable. This study was designed elucidate impact cornelian cherry iridoid-polyphenolic extract (CE) loganic acid (LA) on adherent-invasive E. coli growth adhesion in vitro assess...
Inflammatory diseases are a common therapeutic problem and nonsteroidal anti-inflammatory drugs not deprived of side effects, which ulcerogenic activity is one the most frequent. The aim study was to evaluate sanguinarine-chelerythrine (SC) fraction Coptis chinensis its influence on integrity gastric mucosa. conducted sixty male rats randomly divided into six experimental groups: two control groups (a negative group CON positive CAR); three receiving an investigational C. (1, 5, 10 mg/kg...
Cornelian cherry (Cornus mas L.) fruits, abundant in iridoids and anthocyanins, are natural products with proven beneficial impacts on the functions of cardiovascular system liver. This study aims to assess compare whether what extent two different doses resin-purified cornelian extract (10 mg/kg b.w. or 50 b.w.) applied a cholesterol-rich diet rabbit model affect levels sterol regulatory element-binding protein 1c (SREBP-1c) CCAAT/enhancer binding α (C/EBPα), various liver X receptor-α...
Background.Female inflorescences of hops (Humulus lupulus L.) are wildly used in the brewing industry.Hops have been also for ages folk medicine.Xanthohumol (XN) is a most abundant prenylated flavonoid present hops. Objectives.To determine pharmacokinetic parameters and bioavailability pure XN given prenylflavonoid extract obtained from spent (HOP).Material methods.Fifty-six Wistar rats (28 females 28 males) were administered with or HOP.Xanthohumol was either intravenously (iv.) (10 mg/kg)...
Amyloid deposits and hyperphosphorylation of the tau protein are still believed to be two main causes Alzheimer's disease. However, newer studies show beneficial (including antiradical antimicrobial) effects amyloid at physiological concentrations. Therefore, this study aimed investigate impact three fragments - 25-35, 1-40, 1-42 concentrations close levels on oxidative stress induced by administration lipopolysaccharide (LPS) or co-culturing with microglia cells. Differentiated SH-SY5Y...
One of the major side effects cyclophosphamide (CPX)-an alkylating anticancer drug that is still clinically used-is urotoxicity with hemorrhagic cystitis. The present study was designed to evaluate ability carvedilol protect rats from cyclophosphamide-induced urotoxicity. Rats were injected intraperitoneally (i.p.) CPX (200 mg/kg) and administered (2 intragastrically a day before, at after single i.p. injection CPX, or without mesna (40, 80, 80 mg/kg 20 min 4 h 8 administration,...
Background and aim: The use of dietary supplements (DS) over-the-counter (OTC) drugs is increasing every year. COVID-19 pandemic might additionally influence the such preparations. study aimed to investigate factors influencing (DS), including stress-relieving supplements, by students. Methods: In cross-sectional study, 624 students Wroclaw Medical University in Poland, from second last year studies, completed anonymous questionnaire, consisting 22 items, about DS/OTC during academic...
Background.Results of animal studies show that a high-cholesterol diet increases bone resorption and decreases formation, thus leading to osteoporosis.Previously, we reported on the beneficial influence Cornelian cherry (Cornus mas L.) fruit lipid profile in an model diet-induced hipercholesterolemia.Objectives.To investigate Cornus L. extract loganic acid (LA) cholesterolinduced changes. Material methods.The study was conducted 50 New Zealand rabbits.The animals were given either standard...
Cornelian cherry (Cornus mas L.) fruits, abundant in iridoids and anthocyanins, are natural products with proven beneficial impact on the functions of cardiovascular system liver. The aim this study is to stipulate compare whether what extent two different doses resin-purified cornelian extract (10 mg/kg b.w. or 50 b.w.) applied a cholesterol-rich diet rabbit model affect levels ATP-binding cassette transporter A1, G1, CCAAT/enhancer binding protein α, sterol regulatory ele-ment-binding 1c,...
The aim of the current study was to investigate influence cornelian cherry (Cornus mas L.; CM) extract on ovariectomy-induced metabolic changes including bone loss, obesity development, adipokines imbalance and oxidative stress. Intragastrical administration CM ameliorated weight gain decreased accumulation visceral fat tissue. It counteracted imbalance, increasing visfatin resistin decreasing adiponectin levels. reduced stress normalizing GPx, SOD activity, GSH/GSSG ratio. decrease in...