A5011959677- interferon and immune responses
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Vectors
- Heat shock proteins research
- Respiratory viral infections research
- ATP Synthase and ATPases Research
- Respiratory Support and Mechanisms
- Mosquito-borne diseases and control
- Signaling Pathways in Disease
- Pediatric health and respiratory diseases
- Plant Stress Responses and Tolerance
- Immune responses and vaccinations
- Plant Molecular Biology Research
- Inflammasome and immune disorders
- Bioactive Compounds and Antitumor Agents
- Bone Metabolism and Diseases
Heidelberg University
2020-2023
German Cancer Research Center
2020-2023
Ludwig-Maximilians-Universität München
2021
Urologische Klinik München
2021
SARS-CoV-2 is a novel virus that has rapidly spread, causing global pandemic. In the majority of infected patients, leads to mild disease; however, in significant proportion infections, individuals develop severe symptoms can lead long-lasting lung damage or death. These cases are often associated with high levels pro-inflammatory cytokines and low antiviral responses, which cause systemic complications. Here, we have evaluated transcriptional cytokine secretion profiles detected distinct...
Abstract SARS-CoV-2 is a novel virus that has rapidly spread, causing global pandemic. In the majority of infected patients, leads to mild disease; however, in significant proportion infections, individuals develop severe symptoms can lead permanent lung damage or death. These cases are often associated with high levels pro-inflammatory cytokines and low antiviral responses which systemic complications. We have evaluated transcriptional cytokine secretion profiles from cell cultures detected...
Host cell-intrinsic antiviral responses are largely mediated by pattern-recognition receptor (PRR) signaling and the interferon (IFN) system. The IFN regulatory factor (IRF) family of transcription factors takes up a central role in transcriptional regulation innate immunity. IRF3 IRF7 known to be key players downstream PRRs mediating induction type I III IFNs. then requires IRF9 for expression full array stimulated genes (ISGs) ultimately defining state cell. Other members IRF clearly play...
RIG-I recognizes viral dsRNA and activates a cell-autonomous antiviral response. Upon stimulation, it triggers signaling cascade leading to the production of type I III IFNs. IFNs are secreted signal elicit expression IFN-stimulated genes, establishing an state cell. The topology this pathway has been studied intensively, however, its exact dynamics less understood. Here, we employed electroporation synchronously activate RIG-I, enabling us characterize cell-intrinsic innate immune at high...
Abstract The risk of developing severe COVID‐19 rises dramatically with age. Schoolchildren are significantly less likely than older people to die from SARS‐CoV‐2 infection, but the molecular mechanisms underlying this age‐dependence unknown. In primary infections, innate immunity is critical due lack immune memory. Children, in particular, have a stronger interferon response primed state their airway epithelium. single‐cell transcriptomes nasal turbinates, we find increased frequencies...
Abstract Plant growth and development are modulated by both biotic abiotic stress. Increasing evidence suggests that cellular integration of the corresponding signals occurs within preformed hubs at plasma membrane called nanodomains. These sub-compartments organized multivalent molecular scaffold proteins, such as remorins. Here, we demonstrate Group 1 remorins form a hetero-oligomeric complex membrane. While these functionally redundant for some pathways their multivalency also allows...
Properly responding to DNA damage is vital for eukaryotic cells, including the induction of repair, growth arrest and, as a last resort prevent neoplastic transformation, cell death. Besides being crucial ensuring homeostasis, same pathways and mechanisms are at basis chemoradiotherapy in cancer treatment, which involves therapeutic by chemical or physical (radiological) measures. Apart from typical response mediators, relevance cell-intrinsic antiviral signaling breaks has recently emerged....
Abstract To cope with novel virus infections to which no prior adaptive immunity exists, the body strongly relies on innate immune system. In such cases, including SARS-CoV-2, children tend fair better than adults. context of COVID-19, it became evident that a rapid interferon response at site primary infection is key for successful control and prevention severe disease. The airway epithelium was shown exhibit primed state already homeostasis respond particularly well SARS-CoV-2 infection....
Plumbagin is used in traditional medicine because of its anti-inflammatory and anti-microbial properties. As a naphthoquinone, plumbagin triggers the production reactive oxygen species (ROS). In vitro cancer studies showed that apoptosis cells through ROS production. cancer-mediated chronic inflammation can affect bone density, it was hypothesized might directly inhibit formation bone-resorbing osteoclasts. We previously effect on osteoclastogenesis differed between marrow-derived...
ABSTRACT The pattern recognition receptor RIG-I is essential for the of viral dsRNA and activation a cell-autonomous antiviral response. Upon stimulation, triggers signaling cascade leading to expression cytokines, most prominently type I III interferons (IFNs). IFNs are secreted signal in an auto- paracrine manner trigger large variety IFN-stimulated genes, which concert establish state cell. While topology this pathway has been studied quite intensively, dynamics, particularly...
Abstract Properly responding to DNA damage is vital for eukaryotic cells, including the induction of repair, growth arrest and, as a last resort prevent neoplastic transformation, cell death. Besides being crucial ensuring homeostasis, same pathways and mechanisms are at basis chemoradiotherapy in cancer treatment, which involves therapeutic by chemical or physical (radiological) measures. Apart from typical response mediators, relevance cell-intrinsic antiviral signaling breaks has recently...