A5088966629- Alzheimer's disease research and treatments
- Ultrasound and Hyperthermia Applications
- Barrier Structure and Function Studies
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Phytochemistry and biological activities of Ficus species
- Cerebrovascular and genetic disorders
- Supramolecular Self-Assembly in Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Geomagnetism and Paleomagnetism Studies
- Lipid Membrane Structure and Behavior
- Magnetic Field Sensors Techniques
- Caveolin-1 and cellular processes
- Geophysical and Geoelectrical Methods
- Cell Image Analysis Techniques
- Cholinesterase and Neurodegenerative Diseases
- Vagus Nerve Stimulation Research
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Natural Antidiabetic Agents Studies
- Advanced Neuroimaging Techniques and Applications
Park Centre for Mental Health
2018-2020
The University of Queensland
2018-2020
Tata Institute of Fundamental Research
1985-2019
Bombay College of Pharmacy
2010
Intracellular deposits of pathological tau are the hallmark a broad spectrum neurodegenerative disorders collectively known as tauopathies, with Alzheimer's disease, secondary tauopathy, being further characterized by extracellular amyloid plaques. A major obstacle in developing effective treatments for tauopathies is presence blood-brain barrier, which restricts access therapeutic agents to brain. An emerging technology overcome this limitation application low-intensity ultrasound which,...
The blood-brain barrier (BBB) presents a for circulating factors, but simultaneously challenges drug delivery. How the BBB is altered in Alzheimer disease (AD) not fully understood. To facilitate this analysis, we derived brain endothelial cells (iBECs) from human induced pluripotent stem (hiPSCs) of several patients carrying familial AD PSEN1 mutation. We demonstrate that, compared with isogenic corrected and control iBECs, AD-iBECs exhibit tight adherens junction protein expression as well...
The blood-brain barrier (BBB) is a dynamic diffusional regulating the molecular and chemical flux between blood brain, thereby preserving cerebral homeostasis. Endothelial cells form core anatomical component of BBB based on properties such as specialized junctional complexes cells, which restricts paracellular transport, extremely low levels vesicular restricting transcytosis. In performing its protective function, also constrains entry therapeutics into hampering treatment various...
Small hydrophobic oligomers of aggregation-prone proteins are thought to be generically toxic. Here we examine this view by perturbing an early folding contact between Phe19 and Leu34 formed during the aggregation Alzheimer's amyloid-β (Aβ40) peptide. We find that even conservative single mutations altering interaction can abolish Aβ40 toxicity. Significantly, mutants not distinguishable either size or end-state fibrillar structure from wild type Aβ40. trace change in their toxicity a...
The blood-brain barrier presents a major challenge for the delivery of therapeutic agents to brain; however, it can be transiently opened by combining low intensity ultrasound with microbubble infusion. Studies evaluating this technology have largely been performed in rodents, including models neurological conditions. However, despite promising outcomes terms drug and amelioration impairments, potential long-term adverse effects concern context clinical applications. Methods: To fill gap, we...
Purpose Heterozygous TUBA1A variants are a well-recognised cause of malformations cortical development (MCDs). Although existing literature − predominantly radiologically ascertained cohorts suggests complete penetrance the MCD phenotype in this condition, there is also anecdotal contrary evidence. Understanding clinical spectrum TUBA1A-related disorders informs counselling and decisions, especially for those identified early life. Methods Individuals with were through large exome sequencing...
The authors have used an existing design of inexpensive mutual inductance bridge circuit to build AC susceptometer from 1.5 300K. simple the entire system and use low-cost components are special features this system. has a sensitivity 5*10-7 EMU which can be improved further by using superior electronic components.
While the roles of intrinsically disordered protein domains in driving interprotein interactions are increasingly well-appreciated, mechanism toxicity disease-causing proteins remains poorly understood. A prime example is Alzheimer's disease (AD) associated amyloid beta (Aβ). Aβ oligomers highly toxic partially structured peptide assemblies with a distinct ordered region (residues ∼10–40) and shorter ∼1–9). Here, we investigate role this domain its relation to manifestation through set...
Alzheimer's disease is characterized by amyloid-β and tau deposition. A challenge in targeting these molecules presented the blood-brain barrier (BBB), that limits brain uptake of therapeutic agents. The BBB can be transiently opened intravenously injecting microbubbles followed delivering ultrasound through skull into brain. We have shown previously applying scanning (SUS) to APP23 mice, was removed memory functions restored without using any agent. As an underlying mechanism we identified...
While the roles of intrinsically disordered protein domains in driving many interactions are increasingly well‐appreciated, mechanism toxicity disease‐causing proteins remains poorly understood. A prime example is Alzheimer's disease (AD) associated amyloid beta (Aβ). Aβ oligomers highly toxic partially structured peptide assemblies with a distinct ordered region (residues ~10–40) and shorter ~1–9). Here, we investigate role this domain its relation to manifestation through set fragments...