A5059442438- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Facial Nerve Paralysis Treatment and Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Acupuncture Treatment Research Studies
- EEG and Brain-Computer Interfaces
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Mental Health Research Topics
- Neonatal and fetal brain pathology
- Peripheral Nerve Disorders
- Transcranial Magnetic Stimulation Studies
- Posttraumatic Stress Disorder Research
- Trigeminal Neuralgia and Treatments
- Stroke Rehabilitation and Recovery
- Cardiac Arrest and Resuscitation
- Vestibular and auditory disorders
- Olfactory and Sensory Function Studies
- Motor Control and Adaptation
- Advanced MRI Techniques and Applications
- S100 Proteins and Annexins
- Neural dynamics and brain function
- Health disparities and outcomes
The University of Queensland
2018-2024
Sunshine Coast University Hospital
2021-2024
University of the Sunshine Coast
2021-2024
Institute for Health Metrics and Evaluation
2024
University of Washington
2024
New York University Abu Dhabi
2024
Kyung Hee University
2014-2017
Graduate School USA
2017
Cairo University
2017
Athinoula A. Martinos Center for Biomedical Imaging
2017
Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have emerged as independent risk factors for an earlier onset of Alzheimer’s disease (AD), although the pathophysiology underlying this is unclear. Postmortem studies revealed extensive cerebral accumulation tau following multiple single TBI incidents. We hypothesized that a history and/or PTSD may induce AD-like pattern in nondemented war veterans. Vietnam War veterans (mean age 71.4 years) with war-related underwent...
Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are risk factors for early onset of Alzheimer's disease (AD) may accelerate the progression rate AD pathology. As amyloid-beta (Aβ) plaques a hallmark pathology, we hypothesized that TBI PTSD might increase Aβ accumulation in brain. We examined PET neuropsychological data from Vietnam War veterans compiled by US Department Defense Disease Neuroimaging Initiative, to examine spatial distribution male veterans' who had...
The brainstem is a crucial component of the central autonomic nervous (CAN) system. Functional MRI (fMRI) remains challenging due to range factors, including diverse imaging protocols, analysis, and interpretation.
An extensive library of symptom inventories has been developed over time to measure clinical symptoms traumatic brain injury (TBI), but this variety led several long-standing issues. Most notably, results drawn from different settings and studies are not comparable. This creates a fundamental problem in TBI diagnostics outcome prediction, namely that it is possible equate distinct tools inventories. Here, we present an approach using semantic textual similarity (STS) link scores across...
The blood-brain barrier presents a major challenge for the delivery of therapeutic agents to brain; however, it can be transiently opened by combining low intensity ultrasound with microbubble infusion. Studies evaluating this technology have largely been performed in rodents, including models neurological conditions. However, despite promising outcomes terms drug and amelioration impairments, potential long-term adverse effects concern context clinical applications. Methods: To fill gap, we...
Abstract While the dire cardiometabolic consequences of hypercaloric modern ‘Western’ diet are well known, there is not much information on health impact a high sucrose inducing weight gain. Here, we tested hypothesis that rats reared with intermittent binge access to in addition normal chow would develop an inflammatory response brain. To test this hypothesis, undertook serial PET/MRI scans TSPO ligand [ 18 F]DPA714 group (n=9) at baseline and again after voluntarily consuming 5% solution...
Neuroinflammatory reactions play a significant role in the pathology and long-term consequences of traumatic brain injury (TBI) may mediate salutogenic processes that white matter integrity. This study aimed to investigate relationship between inflammatory markers integrity following TBI both rat model clinical cases. In model, blood samples were collected controlled cortical impact (CCI) assess panel markers; MR-based diffusion tensor imaging (DTI) was employed evaluate 60 days post-injury....
Abstract Wellbeing is protective against the emergence of psychopathology. Neurobiological markers associated with mental wellbeing during adolescence are important to understand. Limited research has examined neural networks (white matter tracts) and in early specifically. A cross-sectional diffusion tensor imaging analysis approach was conducted, from Longitudinal Adolescent Brain study, First Hundred Brains cohort ( N = 99; 46.5% female; M age 13.01, SD 0.55). Participants completed...
Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions this devastating neurological disorder. However, failure rate translation drugs from animal testing to human treatments TBI is 100%. While there several potential explanations this, previous clinical trials have relied on extrapolation preclinical studies critical design considerations, including drug dose optimization, post-injury treatment...
Diffuse traumatic brain injury (TBI) is known to lead microstructural changes within both white and grey matter detected in vivo with diffusion tensor imaging (DTI). Numerous studies have shown alterations fractional anisotropy (FA) mean diffusivity (MD) prominent tracts, but few linked these the confirmation via histological assessment. This especially important as may be predictive of long-term functional deficits.A total 33 male Sprague Dawley rats underwent severe closed-head TBI. Eight...
Bell's palsy is the most common cause of acute facial nerve paralysis. In China, frequently treated with acupuncture. However, its efficacy and underlying mechanism are still controversial. this study, we used functional MRI to investigate effect acupuncture on connectivity brain in patients healthy individuals. The were further grouped according disease duration motor performance. results resting-state show that induces significant changes primary somatosensory region both early late...
Abstract Previous neuroimaging studies in rodents investigated effects of the controlled cortical impact (CCI) model traumatic brain injury (TBI) within one-month post-TBI. This study extends this temporal window to monitor structural–functional alterations from two hours six months post-injury. Thirty-seven male Sprague–Dawley rats were randomly assigned TBI and sham groups, which scanned at hours, 1, 3, 7, 14, 30, 60 days, following CCI or surgery. Structural MRI, diffusion tensor imaging,...
Each human brain has a unique functional synchronisation pattern (functional connectome) analogous to fingerprint that underpins functions and related behaviours. Here we examine connectome (whole-brain 13 networks) maturation by measuring its uniqueness in adolescents who underwent scans longitudinally from 12 years of age every four months. The is defined as ratio self-similarity (from the same subject at different time point) maximal similarity-to-others given any others point). We found...
Early loss of white matter microstructure integrity is a significant cause long-term neurological disorders following traumatic brain injury (TBI). White abnormalities typically involve axonal and demyelination. In-vivo imaging tools to detect differentiate such microstructural changes are not well-explored. This work utilizes the conjoint potential offered by advanced magnetic resonance techniques, including quantitative susceptibility mapping (QSM) diffusion tensor (DTI), discern...
Bell’s palsy (BP), a unilateral and idiopathic of the facial nerve, is common disorder generally followed by good natural recovery. The aim this study was to investigate relationship between functional connectivity anterior cingulate cortex (ACC) recovery process BP. Thirty-seven healthy volunteers 67 patients were studied MRI (fMRI). seed regions bilateral ACC first extracted from task-state fMRI data participants performing task mouth opening closing. calculated resting-state in whom only...
Traumatic brain injury (TBI) is associated with gray and white matter alterations in tissue. Gray are not yet as well studied those of the counterpart. This work utilized T2-weighted structural imaging, diffusion tensor imaging (DTI), kurtosis to unveil changes induced a controlled cortical impact (CCI) mouse model TBI at 5 h, 1 day, 3 days, 7 14 30 days post-CCI. A cross-sectional histopathology approach was used confer validity magnetic resonance (MRI) data by performing cresyl violet...
Abstract Objective. Soft-robotic-assisted training may improve motor function during post-stroke recovery, but the underlying physiological changes are not clearly understood. We applied a single-session of intensive proprioceptive stimulation to stroke survivors using soft robotic glove delineate its short-term influence on brain functional activity and connectivity. Approach. In this study, we utilized task-based resting-state magnetic resonance imaging (fMRI) characterize in different...
Traumatic brain injury (TBI) has come to be recognized as a risk factor for Alzheimer's disease (AD), with poorly understood underlying mechanisms. We hypothesized that history of TBI would associated greater tau deposition in elders high-risk dementia. A Groups 20 participants self-reported and 100 without any such were scanned using [
Objectives Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating chronic illness for which there are no well-accepted treatments, aside from some preliminary trials symptom management strategies, such as low-dose naltrexone NICE guidelines. A clinician administered synergistic off-label treatment (SOT) involving spironolactone, colchicine, naltrexone, multivitamins to ME/CFS patients, resulting in reported improvement. This study sought investigate...