A5080103235- Advanced NMR Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Sulfur-Based Synthesis Techniques
- Quantum Dots Synthesis And Properties
- Various Chemistry Research Topics
- History and advancements in chemistry
- Nanocluster Synthesis and Applications
- Fluorine in Organic Chemistry
- Advanced MRI Techniques and Applications
- Crystallization and Solubility Studies
- Atomic and Subatomic Physics Research
- Ubiquitin and proteasome pathways
- Synthesis and Catalytic Reactions
- Analytical Chemistry and Chromatography
- X-ray Diffraction in Crystallography
- Electron Spin Resonance Studies
- bioluminescence and chemiluminescence research
- Molecular spectroscopy and chirality
- Silk-based biomaterials and applications
- RNA regulation and disease
- Synthesis of heterocyclic compounds
- Science, Research, and Medicine
- Mosquito-borne diseases and control
- Solid-state spectroscopy and crystallography
- Science Education and Perceptions
The Nature Conservancy
2023-2025
Institute of Catalysis and Petrochemistry
2023
University of Glasgow
2021-2022
University of Nottingham
2015-2021
Park University
2018
University of Lincoln
2018
University of Aberdeen
2017
University of Ferrara
2011
This microreview highlights the utility of 1,4‐dithiane‐2,5‐diol ( 1 ) as a source for in situ generation 2‐mercaptoacetaldehyde 2 ), versatile two‐carbon synthon featuring both electrophilic and nucleophilic reaction centres widely utilized an attractive platform preparation sulfur‐containing molecules. We discuss chemistry involved, mainly focusing on its applications to construction heterocyclic compounds including thiophene 1,3‐thiazole families other different sulfur–nitrogen...
Stability, biocompatibility and near-infrared photoluminescence of PbS nanocrystals capped with PEG-based ligands open up realistic prospects for non-invasive bioimaging applications.
Proteasome activity affects cell cycle progression as well the immune response, and it is largely recognized an attractive pharmacological target for potential therapies against several diseases. Herein we present synthesis of a series pseudodi/tripeptides bearing at C-terminal position different α-ketoamide moieties pharmacophoric units interaction with catalytic threonine residue that sustains proteolytic action proteasome. Among these, identified 1-naphthyl derivative 13c potent selective...
Hyperpolarization enhances the intensity of NMR signals a molecule, whose in vivo metabolic fate can be monitored by MRI with higher sensitivity. SABRE is hyperpolarization technique that could potentially used to image nitric oxide (NO) production vivo. This would very important, because NO dysregulation involved several pathologies, including cardiovascular ones. The synthase (NOS) pathway leads via conversion l-arginine into l-citrulline. free radical gas short half-life (≈5s), therefore...
Abstract We report a new theranostic device based on lead sulfide quantum dots (PbS QDs) with optical emission in the near infrared wavelength range decorated affibodies (small 6.5 kDa protein-based antibody replacements) specific to cancer biomarker human epidermal growth factor receptor 2 (HER2), and zinc(II) protoporphyrin IX (ZnPP) combine imaging, targeting therapy within one nanostructure. Colloidal PbS QDs were synthesized aqueous solution nanocrystal diameter of ∼5 nm...
We report on the synthesis of water-soluble gold nanoclusters capped with polyethylene glycol (PEG)-based ligands and further functionalized folic acid for specific cellular uptake. The dihydrolipoic acid-PEG-based terminated -OMe, -NH2 -COOH functional groups are produced used surface passivation Au (NCs) diameters <2 nm. sub 2 nm NCs possess long-shelf life stable in physiologically relevant environments (temperature pH), paramagnetic biocompatible. paramagnetism solution is also reported....
Abstract An approach for hyperpolarized 129 Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated within the vicinity of center experiences fast that, through exchange xenon atoms between cage and solvent pool, causes accelerated signal decay in dissolved phase. In this proof‐of‐concept work, relaxivity Gadolinium III ‐DOTA on was increased eightfold tethering molecule to a...
The maturation of spirit in wooden casks is key to the production whisky, a hugely popular and valuable product, with transfer reaction molecules from cask alcoholic imparting color flavor. However, time adds significant cost final requiring expensive barrels decades careful storage. Thus, many producers are concerned what "age" means terms chemistry flavor profiles whisky. We demonstrate here colorimetric test for "agedness" based on formation gold nanoparticles (NPs) by Gold salts were...
Paramagnetic gadolinium ions (GdIII), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, "on/off" probes serving as 19F·MRI biosensors for target enzymes emerged that utilize transverse (T2∗ or T2) relaxation times upon cleavage paramagnetic GdIII centre. Molecular has advantage high specificity due lack background signal but suffers from low intensity leads spatial resolution and long...
Abstract Recombinant spider silk has the potential to provide a new generation of biomaterial scaffolds as result its degree biocompatibility and lack immunogenicity. These recombinant biomaterials are, however, reported exhibit poor cellular adhesion which limits their for use in applications such tissue engineering regenerative medicine. In this study, simple chemical functionalization approach is described that specifically addresses issue significantly improves human mesenchymal stem...
Aedes albopictus (Skuse) (Diptera: Culicidae), an aggressive and annoying vector of several arbovirus including Chikungunya Zika, is a serious health problem worldwide. Control this mosquito difficult because high adaptability, egg resistance to dehydration ability exploit many man-made microhabitats. The most effective strategy appears the control larval population. Based on previous data showing larvicidal effect plant extracts containing sulfhydryl isothiocyanate compounds, we evaluated...