A5103178469- Orthopaedic implants and arthroplasty
- Spine and Intervertebral Disc Pathology
- Hip and Femur Fractures
- Hip disorders and treatments
- Spinal Fractures and Fixation Techniques
- Bone Tissue Engineering Materials
- Bone health and osteoporosis research
- Management of metastatic bone disease
- Bone and Joint Diseases
- biodegradable polymer synthesis and properties
- Graphene and Nanomaterials Applications
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Bone fractures and treatments
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Ergonomics and Musculoskeletal Disorders
- Click Chemistry and Applications
- Diabetic Foot Ulcer Assessment and Management
- Additive Manufacturing and 3D Printing Technologies
- Shoulder and Clavicle Injuries
- Cerebral Palsy and Movement Disorders
- Sports injuries and prevention
Mayo Clinic
2017-2025
Mayo Clinic in Florida
2018-2025
Mayo Clinic in Arizona
2017-2021
WinnMed
2017-2018
Traditional polymer systems often rely on toxic initiators or catalysts for cross-linking, posing significant safety risks. For bone tissue engineering, another issue is that the scaffolds take a longer time to degrade, inconsistent with formation pace. Here, we developed an enzyme-responsive biodegradable poly(propylene fumarate) (PPF) and polycaprolactone (PCL) polyphosphoester (PPE) dendrimer cross-linked utilizing click chemistry (EnzDeg-click-PFCLPE scaffold) enhanced biocompatibility...
Background/Objectives: Limited spinal range of motion (ROM) is linked to low back disorders, emphasizing the need maintain mobility in elderly. This study measured maximum ROM, asymmetrical patterns, and effects age muscle activation on mobility. Methods: Forty healthy participants aged 50 older were recruited. An optical capture system recorded three-dimensional coordinates reflective markers placed landmarks. Asymmetry was analyzed sidebending axial rotation. Electromyography (EMG) data...
Spinal injuries or diseases necessitate effective fusion solutions, and common clinical approaches involve autografts, allografts, various bone matrix products, each with limitations. To address these challenges, we developed an innovative moldable click chemistry polymer cement that can be shaped by hand self-cross-linked in situ for spinal fusion. This self-cross-linking cement, enabled the bioorthogonal reaction, excludes need toxic initiators external energy sources. The bioactivity of...
Background Longevity is increasing worldwide due to improvements in healthcare and living standards. Aging often associated with disability multiple health concerns. To address these challenges, effective interventions are essential. This study investigated potential age-related declines gait, balance, strength. We also sought assess any relationships between three parameters explore differences women men. Methods Healthy individuals over 50 years of age were recruited for this...
Current bone cement systems often demand free radical or metal-related initiators and/or catalysts for the crosslinking process, which may cause serious toxicity to human body. In addition, resultant dense scaffolds have a prolonged degradation time and are difficult cells infiltrate form new tissue. this study, we developed porous "click" organic-inorganic nanohybrid (PO-click-ON) that crosslinks via metal-free biorthogonal click chemistry forms structures mimicking native tissue...
Abstract Polycaprolactone fumarate (PCLF) is a cross‐linkable PCL derivative extensively considered for tissue engineering applications. Although injection molding has been widely used to develop PCLF scaffolds, platforms developed using such technique lack precise control on architecture, design, and porosity required ensure adequate cellular responses. In particular, the scaffolds should provide suitable surface cell attachment proliferation, facilitate cell–cell communication nutrient...
Abstract Degenerative spinal pathology is a widespread medical issue, and spine fusion surgeries are frequently performed. In this study, we fabricated an injectable bioactive click chemistry polymer cement for use in bone regrowth. Taking advantages of the bioorthogonal reaction, can be crosslinked by itself eliminating addition toxic initiator or catalyst, nor any external energy sources like UV light heat. Furthermore, nano‐hydroxyapatite (nHA) microspheres carrying recombinant human...
A wide range of materials have been used for the development intervertebral cages. Poly(propylene fumarate) (PPF) has shown to be an excellent biomaterial with characteristics similar trabecular bone. Hydroxyapatite (HA) enhance biocompatibility and mechanical properties PPF. The purpose this study was characterize effect PPF augmented HA (PPF:HA) evaluate feasibility material cervical synthesized combined at PPF:HA wt:wt ratios 100:0, 80:20, 70:30, 60:40. Molds were fabricated testing bulk...
Cadaveric fracture testing is routinely used to understand factors that affect proximal femur strength. Because ex vivo biological tissues are prone lose their mechanical properties over time, specimen preparation for experimental must be performed carefully obtain reliable results represent in conditions. For reason, we designed a protocol and set of fixtures prepare the femoral specimens such experienced minimal changes. The femora were kept frozen state except during steps testing....
About 1.8 million new cancer cases are estimated in the US 2019 from which 50-85% might metastasize to thoracic and lumbar spines. Subject-specific quantitative computed tomography-based finite element analysis (QCT/FEA) is a promising used tool predict vertebral fracture properties. The aims of this study were twofold: First, develop an optimized equation for elastic modulus accounting all input parameters FE modeling Second, assess effect lesion size location on predicted loads. An inverse...