A5082535427- Advanced biosensing and bioanalysis techniques
- Photochromic and Fluorescence Chemistry
- Marine Toxins and Detection Methods
- Pharmacogenetics and Drug Metabolism
- DNA and Nucleic Acid Chemistry
- Steroid Chemistry and Biochemistry
- Cellular transport and secretion
- Carbohydrate Chemistry and Synthesis
- Molecular Junctions and Nanostructures
- Supramolecular Self-Assembly in Materials
- Aquatic Ecosystems and Phytoplankton Dynamics
- Luminescence and Fluorescent Materials
- Cyclopropane Reaction Mechanisms
- Synthesis of Organic Compounds
- Marine Sponges and Natural Products
- Pancreatic function and diabetes
- Glycogen Storage Diseases and Myoclonus
- Hormonal Regulation and Hypertension
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Marine and coastal ecosystems
- Synthetic Organic Chemistry Methods
- Metal-Catalyzed Oxygenation Mechanisms
- Calcium signaling and nucleotide metabolism
University of Freiburg
2019-2021
University of Basel
2016
Abstract Fuel‐driven self‐assemblies are gaining ground for creating autonomous systems and materials, whose temporal behavior is preprogrammed by a reaction network. However, up to now there has been lack of simple external control mechanisms the transient behavior, at best using remote benign light control. Even more challenging use different wavelengths modulate reactivity components system, example, as fuel or building blocks. Success would enable such navigate along trajectories in...
There has been a recent upsurge in the study and application of approaches utilizing cyclotriphosphate 1 (cyclo-TP, also known as trimetaphosphate, TMP) and/or proceeding through its analogues synthetic chemistry to access modified oligo- polyphosphates. This is especially useful area chemical nucleotide synthesis, but by no means restricted it. Enabled new high yielding easy-to-implement methodologies, these promise open up an research that previously underappreciated. Additionally,...
Harmful algal blooms are becoming more prevalent all over the world, and identification mechanism-of-action studies of responsible toxins serve to protect ecosystems, livestock, humans alike. In this study, chlorosulfopeptide aeruginosin 828A, which rivals well-known toxin microcystin LR in terms crustacean toxicity, has been synthesized for first time. Furthermore, three congeners with different permutations chloride sulfate groups were prepared, thereby enabling toxicity without risk...
Abstract Fuel‐driven self‐assemblies are gaining ground for creating autonomous systems and materials, whose temporal behavior is preprogrammed by a reaction network. However, up to now there has been lack of simple external control mechanisms the transient behavior, at best using remote benign light control. Even more challenging use different wavelengths modulate reactivity components system, example, as fuel or building blocks. Success would enable such navigate along trajectories in...
β-Cells respond directly to the intracellular photochemical release of caged inositol pyrophosphate isomers with modulations oscillations in cytosolic Ca<sup>2+</sup>.
Abstract Enzymatic hydroxylation of unactivated primary carbons is generally associated with the use molecular oxygen as co-substrate for monooxygenases. However, in anaerobic cholesterol-degrading bacteria such Sterolibacterium denitrificans carbon isoprenoid side chain oxidised to a carboxylate absence oxygen. Here, we identify an enzymatic reaction sequence comprising two molybdenum-dependent hydroxylases and one ATP-dependent dehydratase that accomplish C26 methyl group cholesterol...
Inositol pyrophosphates constitute a family of hyperphosphorylated signaling molecules involved in the regulation glucose uptake and insulin sensitivity. While our understanding biological roles inositol heptaphosphates (PP-InsP5) has greatly improved, functions octaphosphates ((PP)2-InsP4) have remained unclear. Here we present synthesis two enantiomeric cell-permeant photocaged (PP)2-InsP4 derivatives apply them to study living β-cells. Photorelease naturally occurring isomer...
Photocages have been successfully applied in cellular signaling studies for the controlled release of metabolites with high spatio-temporal resolution. Commonly, coumarin photocages are activated by UV light and quantum yields uncaging relatively low, which can limit their applications vivo. Here, syntheses, determination photophysical properties, chemical calculations 7-diethylamino-4-hydroxymethyl-thiocoumarin (thio-DEACM) caged adenine nucleotides reported compared to widely used...
The degradation of cholesterol and related steroids by microbes follows fundamentally different strategies in aerobic anaerobic environments. In bacteria, the primary C26 isoprenoid side chain is hydroxylated without oxygen via a three-step cascade: (i) water-dependent hydroxylation at tertiary C25, (ii) ATP-dependent dehydration to form subterminal alkene, (iii) an allylic alcohol. However, enzymes involved have remained unknown. Here, we isolated 25-hydroxy-steroid kinase (25-HSK) from...
Abstract Gesundheitsschädliche Algenblüten treten weltweit immer häufiger auf. Daher bedarf es Studien zur Identifikation der verantwortlichen Toxine sowie zu deren Wirkmechanismus, um die Ökosysteme inklusive betroffenen Menschen und Tiere schützen können. In hier vorgestellten Arbeit wurde das Chlorsulfopeptid Aeruginosin 828A, für Krebstiere ähnlich toxisch ist wie bekannte Microcystin‐LR, erstmals synthetisiert. Darüber hinaus wurden drei Kongenere mit verschiedenen Permutationen...
Fuel-driven dissipative self-assemblies are gaining ground for creating life-like, active and adaptive materials with autonomous behavior. However, up to now there is a lack simple external control mechanisms of the transient behavior steady-state properties, at best using high spatiotemporal resolution. Here, we introduce first examples an externally controlled, chemically fueled self-assembly system that ultimately powered different colors light. We demonstrate this concept programming...
<div><div><div><p>Fuel-driven dissipative self-assemblies are gaining ground for creating life-like, active and adaptive materials with autonomous behavior. However, up to now there is a lack simple external control mechanisms of the transient behavior steady-state properties, at best using high spatiotemporal resolution. Here, we introduce first examples an externally controlled, chemically fueled self-assembly system that ultimately powered different colors light....