A5069291352- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Tryptophan and brain disorders
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- Health, Environment, Cognitive Aging
- Genomics and Rare Diseases
- Intensive Care Unit Cognitive Disorders
- Frailty in Older Adults
- Bipolar Disorder and Treatment
Engelhardt Institute of Molecular Biology
2022-2024
Sechenov University
2023
The evolution of protein-coding genes has both structural and regulatory components. first can be assessed by measuring the ratio non-synonymous to synonymous nucleotide substitutions. second component measured as normalized proportion transposable elements that are used elements. For time, we characterized in parallel evolutionary profiles for 10,890 human 2972 molecular pathways. We observed a ~0.1 correlation between metrics at gene level, which appeared much higher (~0.4) pathway level....
(1) Background: Older people suffer from cognitive decline; several risk factors contribute to greater decline. We used acquired (COVID-19 infection) and non-modifiable (presence of APOE rs429358 rs7412 polymorphisms) study the progression subjective impairment while observing patients for one year. Cognitive training was as a protective factor. (2) Methods: Two groups subjects over age 65 participated in study: group with decline receiving individuals who did not complain without...
The polygenic risk score (PRS), together with the ɛ4 allele of APOE gene (APOE-ɛ4), has shown high potential for Alzheimer’s disease (AD) prediction. aim this study was to validate model in Russian patients dementia. A microarray-based assay developed identify 21 markers and ɛ alleles gene. This case–control included 348 dementia 519 cognitively normal volunteers. Cerebrospinal fluid (CSF) amyloid-β (Aβ) tau protein levels were assessed 57 patients. PRS APOE-ɛ4 significant genetic factors...
Many studies aim to detect the early phase of dementia. One major ways achieve this is identify corresponding biomarkers, particularly immune blood biomarkers. The objective study was such biomarkers in patients with mild cognitive impairment (MCI) an experiment that included training. A group MCI diagnoses over age 65 participated (n = 136). Measurements functions (using Mini-Mental State Examination scale and Montreal Cognitive Assessment) determination 27 serum were performed twice: on...
Given the high growth rates of cognitive decline among elderly population and lack effective etiological treatments, early diagnosis impairment progression is an imperative task for modern science medicine. It particular interest to identify predictors unfavorable subsequent course disorders, specifically, rapid progression. Our study assessed informative role various risk factors on dynamics mild (MCI) patients. The included patients with MCI (
Dementia has enormous implications for patients and the health care system. Genetic markers are promising detecting risk of cognitive impairment. We hypothesized that genetic variants associated with suicide might significantly increase decline because in older adults is often a consequence investigated several single-nucleotide polymorphisms were initially dementia identified APOE gene alleles. The study was performed subjects over age 65: 112 146 healthy volunteers. MMSE score used to...