A5100611283- Genomics, phytochemicals, and oxidative stress
- Molecular Sensors and Ion Detection
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Circular RNAs in diseases
- Luminescence and Fluorescent Materials
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Synthesis and biological activity
- RNA Interference and Gene Delivery
- Viral Infections and Vectors
- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- Analytical Chemistry and Sensors
- Photochromic and Fluorescence Chemistry
- Toxoplasma gondii Research Studies
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Mosquito-borne diseases and control
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- HIV Research and Treatment
Zhejiang University
2012-2024
Qingdao National Laboratory for Marine Science and Technology
2018-2024
Zhejiang Academy of Medical Sciences
2018-2024
Hangzhou City University
2023-2024
Northeast Normal University
2024
Sichuan University
2019-2023
University of Electronic Science and Technology of China
2022-2023
Yangzhou University
2022
Northern Jiangsu People's Hospital
2022
Guangzhou Medical University
2022
The clinical outcomes of cancer nanovaccine have been largely impeded owing to the low antigen-specific T cell response rate and acquired resistance caused by immunosuppressive tumor microenvironment (TME). Here, we reported a acidity-responsive remodel TME expand recruitment infiltrating lymphocytes (TILs) using hybrid micelles (HM), which encapsulated colony stimulating factor 1 receptor (CSF1-R) inhibitor BLZ-945 indoleamine 2,3-dioxygenase (IDO) NLG-919 in its core displayed model...
Abstract Targeted chemo-phototherapy has received widespread attention in cancer treatment for its advantages reducing the side effects of chemotherapeutics and improving therapeutic effects. However, safe efficient targeted-delivery agents remains a major obstacle. Herein, we successfully constructed an AS1411-functionalized triangle DNA origami (TOA) to codeliver chemotherapeutic drug (doxorubicin, DOX) photosensitizer (indocyanine green, ICG), denoted as TOADI (DOX/ICG-loaded TOA),...
The innate immune system, including the cell-based immunity (mainly apoptosis and phagocytosis) humoral (such as pro-phenoloxidase system), is first defense line of animals against infection pathogens in a non-specific manner, which fine regulated through gene expression regulations. microRNAs (miRNAs) are recognized important regulators expression. To date, however, comprehensive view about regulation by miRNAs not available. address this issue, signature involved were characterized study....
Abstract Breast cancer is a serious health problem worldwide. Inhibition of apoptosis plays major role in breast tumorigenesis. MicroRNAs (miRNAs) play crucial roles the regulation apoptosis. However, by miRNAs has not been intensively investigated. To address this issue, effect miR-100 on cell proliferation different cells was characterized present study. The results showed that significantly upregulated SK-BR-3 compared with other human (MCF7, MDA-MB-453, T47D, HCC1954 and SUM149)....
Previous studies in our laboratory showed that sulforaphane (SFN) induced apoptosis by sustained activation of extracellular regulated protein kinases 1/2 (ERK1/2).However, the underlying mechanisms associated with SFN-induced and downstream cascades which are modulated ERK1/2 were not elucidated.Herein we demonstrated for first time alteration mitochondrial dynamics contributed to human non-small cell lung cancer (NSCLC) cells.Reports Bim only but also promoted proliferation under certain...
Sulforaphane (SFN) inhibited growth in many cancers, but its half-life is 2 h circulation. However, metabolites, sulforaphane-cysteine (SFN-Cys) and sulforaphane-N-acetyl-cysteine (SFN-NAC) had longer half-lives decreased the cell viability both dose- time-dependent manners human prostate cancer. Flow cytometry assay revealed that these two SFN metabolites induced apoptosis with features such as vacuolization, disappeared nuclear envelope, agglutination fragmentation via transmission...
TTK (also known as Mps1) is the core component of spindle assembly checkpoint, which ensures proper distribution chromosomes to daughter cells maintain genome integrity and balance growth division. However, function in tumorigenesis has not been extensively studied, especially relation development gastric cancer. In this study, survival tumor recurrence data related expression level cancer patients were collected analyzed. We observed that was negatively correlated with vivo. also...
As one of the two nucleic acids used by extant biochemistry, RNA is great importance for cellular function and development, its expression can affect cell homeostasis. Therefore, accurate detection key contributor to disease diagnosis, including tumor detection. Compared with conventional methods, molecular beacons (MBs) have high selectivity target molecules detection, which been widely in However, background fluorescence typical MBs will seriously sensitivity accuracy. In addition, poor...
Two new dual channel Schiff base fluorescent probes, Tri-R6G and Tri-Flu, were synthesized, can detect Hg2+ Al3+, respectively. The two probes characterized by FTIR, 1H NMR, 13C NMR HRMS, their optical properties detected UV FL. Test results showed the probes' detection of Al3+ compared to other metal ions (Ag+, Co2+, Cd2+, Mg2+, Cu2+, Ni2+, Ba2+, Pb2+, Cr3+, Zn2+, Hg2+, K+, Ga2+ Fe3+), Besides, limits determined be 1.61 × 10-8 M 1.15 through standard curve plot, photoelectron transfer (PET)...
Sulforaphane (SFN) was demonstrated to induce apoptosis in a variety of cancers via multiple mechanisms. However, owing short half-life circulation, SFN not used for clinical treatment yet. Interestingly, analog, sulforaphane-cysteine (SFN-Cys) has longer metabolism, and we previously that SFN-Cys inhibited invasion human prostate cancer cells. Here, would investigate whether induces find the underlying mechanisms non-small cell lung (NSCLC) Western blots were test molecular linkages among...
An efficient fluorescent probe Pyr-Rhy based on pyrazole was developed, which can detect Hg2+ in water. Its fluorescence properties were studied by UV-vis and spectroscopy, the study results indicated that this selectively via complexation reaction, then cause a remarkable color change from colorless to pink strong enhancement be observed. Furthermore, showed high sensitivity with detection limit down 2.07 × 10-8 M, its stoichiometric ratio toward ions 1 : 1. The sensing mechanism...
Tumorigenesis is a result of uncontrollable cell proliferation which regulated by variety complex factors including miRNAs. The initiation and progression cancer are always accompanied the dysregulation However, underlying mechanism miRNA in cancers still largely unknown. Herein we found that miR-100 was inordinately upregulated sera patients with gastric cancer, indicating might emerge as biomarker for clinical diagnosis cancer. abnormal expression cells mediated novel transcription factor...
It is inevitable to change the function or expression of genes during environmental adaption species. Both giant panda (Ailuropoda melanoleuca) and red (Ailurus fulgens) belong Carnivora have developed similar adaptations same dietary switch bamboos at morphological genomic levels. However, genetic adaptation gene level unclear. Therefore, we aimed examine patterns convergent specialized bamboo-diets. We examined differences in liver pancreas transcriptomes between two species other...