A5089698972- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Asthma and respiratory diseases
- Circadian rhythm and melatonin
- Phytochemicals and Antioxidant Activities
- Cardiac Fibrosis and Remodeling
- Medical and Biological Ozone Research
- Click Chemistry and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Vitamin C and Antioxidants Research
- Drug Transport and Resistance Mechanisms
- Microbial Metabolism and Applications
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Bioactive Natural Diterpenoids Research
- Bioactive natural compounds
- Essential Oils and Antimicrobial Activity
- Redox biology and oxidative stress
- Synthesis of heterocyclic compounds
- Cynara cardunculus studies
- Sphingolipid Metabolism and Signaling
University of Warsaw
2013-2024
White cabbage is one of the most important vegetables grown both in Poland and worldwide. Cabbage contains considerable amounts bioactive compounds such as glucosinolates, vitamin C, carotenoids, polyphenols. Some experiments indicate that from organic production contain more than those conventional production, however, only a few studies have been conducted on cruciferous plants. The presented study has proved fresh cabbage, compared to one, contained significantly less total flavonoids...
A set of nine derivatives, including five brominated compounds, was synthesized and the structures these novel compounds were confirmed using
Abstract The role of cardiac tissue macrophages (cTMs) during pre- and postnatal developmental stages remains in many aspects unknown. We aimed to characterize cTM populations their potential functions based on surface markers. Our situ studies immunostained specimens murine fetuses (from E11to E17) revealed that a significant number embryonic cTMs (phenotyped by CD45, CD68, CD64, F4/80, CD11b, CD206, Lyve-1) resided mostly the subepicardial space, not entire myocardial wall, as observed...
Cardiac macrophages are known from various activities, therefore we presume that microRNAs (miRNAs) produced or released by in cardiac tissue have impact on myocardial remodeling individuals with metabolic syndrome (MetS). We aim to assess the macrophage miRNA profile selecting those molecules potentially exhibit regulatory functions MetS-related remodeling. control and db/db mice (an animal model of MetS) were counted sorted flow cytometry, which yielded two populations:...
For several decades, people have been searching for natural substances of plant origin that, when introduced into the diet, could strengthen immunity, anticancer properties, and support conventional therapy. The development agriculture with implementation various cultivation systems, apart from economic aspect, results in search such conditions that would contribute to obtaining most beneficial product health. Therefore, aim our research is as follows: (a) compare antiproliferative activity...
Abstract New halogenated thiourea derivatives were synthesized via the reaction of substituted phenylisothiocyanates with aromatic amines. Their cytotoxic activity was examined in vitro studies against solid tumors (SW480, SW620, PC3), a hematological malignance (K‐562), and normal keratinocytes (HaCaT). Most compounds more effective SW480 ( 1a , 3a 3b 5j ), K‐562 2b 4a or PC3 5d ) cells than cisplatin, favorable selectivity. anticancer mechanisms studied by Annexin...
Compounds containing dicarboximide skeleton such as succinimides, maleimides, glutarimides, and phthalimides possess broad biological properties including anti-fungal, antibacterial, antidepressant, or analgesic activities. The piperazine ring is found in a wide range of molecules that have demonstrated variety functions anticancer action 5-HT receptors agonist/antagonist activity. In the present study, we combined both structures to develop new antitumor agents, series derivatives...
Event Abstract Back to Diurnal changes in trafficking receptor expression on thymus-deriving natural regulatory T cells Ewelina Kiernozek1*, Anna Kowalik1, Katarzyna Niedzielska1, Magdalena Markowska1 and Nadzieja Drela1 1 University of Warsaw, Poland Natural CD4+CD25+Foxp3+ (nTreg) play a crucial role the maintenance self-tolerance immune homeostasis. nTregs develop thymus migrate periphery as mature population lymphocytes. can suppress activation, proliferation effector functions various...
Event Abstract Back to Can B cells induce the generation of regulatory T cells? Haider H. Mohammed Ali1, Anna Kowalik1, Ewa Kozlowska1, Ewelina Kiernozek1 and Nadzieja Drela1* 1 University Warsaw, Immunology, Poland Regulatory CD4+CD25+Foxp3+ (Tregs) develop in thymus as natural or are generated lymphoid organs induced Tregs. Generation Tregs involves antigen-presenting (APC), mostly immature dendritic cells. It was demonstrated that Foxp3+ were found T-B area peripheral pointing on role...
Event Abstract Back to Dexamethasone dose-dependent effect on nTreg generation in vitro thymocytes co-cultures with JAWSII cells Anna Kowalik1*, Katarzyna Gugala1, Ewelina Kiernozek1, Ewa Kozlowska1 and Nadzieja Drela1 1 University of Warsaw, Immunology, Poland Endogenous glucocorticoids have a broad impact immune development function because their immunosuppressive activity, ability induce apoptosis modulate the maturation antigen-presenting cells. In our research we examined dexamethasone,...
Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress systemic immune response by enhancing activity regulatory M2 macrophages. The aim study was to determine how nematode affects age-related neuroinflammation, especially macrophages nervous tissue. Here, intraperitoneal LPS-induced resulting brain neurodegeneration enhanced prolonged Heligmosomoides polygyrus C57BL/6 mice. changes coincided with increase M1...
Compounds containing dicarboximide skeleton such as succinimides, maleimides, glutarimides, and phthalimides possess broad biological properties including anti-fungal, antibacterial, antidepressant, or analgesic activities. The piperazine ring is found in a wide range of molecules that have demonstrated variety functions anticancer action 5-HT receptors agonist/antagonist activity. In the present study, we combined both structures to develop new antitumor agents, series derivatives...