A5018777462- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- RNA Research and Splicing
- Circular RNAs in diseases
- CNS Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- HIV-related health complications and treatments
- Plant Virus Research Studies
- Endometrial and Cervical Cancer Treatments
- Extracellular vesicles in disease
- Circadian rhythm and melatonin
- CAR-T cell therapy research
- Amino Acid Enzymes and Metabolism
- Metalloenzymes and iron-sulfur proteins
- Dermatology and Skin Diseases
- HIV Research and Treatment
- CRISPR and Genetic Engineering
- Contact Dermatitis and Allergies
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- DNA Repair Mechanisms
- Asthma and respiratory diseases
- Ovarian cancer diagnosis and treatment
The Maria Sklodowska-Curie National Research Institute of Oncology
2015-2025
University of Warsaw
2013
Non-small cell lung cancer (NSCLC) accounts for 80% of cancers, the leading cause mortality. microRNAs (miRNA, miR) have emerged as important components carcinogenesis and promising biomarkers. We aimed to analyse global plasma miRs in NSCLC patients before at least one year after tumour resection. Plasma was collected from peripheral blood 24 donors without surgery (n=36) 1 (n=12). Next-generation sequencing (NGS)-based miR profiling performed. Patients were followed-up 4 12 years assess...
Primary central nervous system lymphoma (PCNSL) is a rare, highly aggressive, extranodal form of non-Hodgkin lymphoma, predominantly diagnosed as primary diffuse large B-cell the (CNS DLBCL). Fast and precise diagnosis PCNSL critical yet challenging. microRNAs, important regulators in physiology pathology are potential biomarkers. In 131 patients with CNS DLBCL non-malignant brain lesions (n-ML), miR-21, miR-19b miR-92a, miR-155, miR-196b, miR-let-7b, miR-125b, miR-9 were examined by RT-qPCR...
Considering the vast biological diversity and high mortality rate in high-grade ovarian cancers, identification of novel biomarkers, enabling precise diagnosis effective, less aggravating treatment, is paramount importance. Based on scientific literature data, we selected 80 cancer-related genes evaluated their mRNA expression 70 serous cancer (HGSOC) samples by Real-Time qPCR. The results were validated an independent Northern American cohort 85 HGSOC patients with publicly available NGS...
Molecular alterations in tumor-adjacent tissues have recently been recognized some types of cancer. This phenomenon has not studied endometrial We aimed to analyze the expression genes associated with cancer progression and metabolism primary samples matched endometria from cancer-free patients uterine leiomyomas. Paired tumors 49 (EC), endometrium 25 leiomyomas uterus, 4 cell lines were examined by RT-qPCR, for MYC, NR5A2, CXCR2, HMGA2, LIN28A, OCT4A, OCT4B, OCT4B1, TWIST1, STK11, SNAI1,...
The diagnosis of primary central nervous system (CNS) lymphoma, which is predominantly the diffuse large B-cell lymphoma type (CNS DLBCL), challenging. MicroRNAs (miRs) are gene expression-regulating non-coding RNAs that potential biomarkers. We aimed to distinguish miR expression patterns differentiating CNS DLBCL and non-malignant diseases with tumor presentation (n-ML). Next generation sequencing-based profiling cerebrospinal fluids (CSFs) brain tumors was performed. Sample...
EMSY, a BRCA2-associated protein, is amplified and overexpressed in various sporadic cancers. This the first study assessing clinical impact of its expression polymorphisms on ovarian cancer (OvCa) outcome context chemotherapy regimen used. In 134 frozen OvCa samples, we assessed EMSY mRNA with Reverse Transcription-quantitative PCR, also investigated gene sequence using SSCP and/or PCR-sequencing. Clinical relevance changes DNA was evaluated two subgroups treated either taxane/platinum (TP,...
Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel. Toxicity caused by dermal respiratory exposures of the general population nickel-containing objects particles deleterious side effect modern technologies. Its molecular mechanism may include peptide bond hydrolysis X
High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare germi-nal centre characterised by typical gain/loss pattern on chromo-some but without MYC translocation. It shares some features Burkitt (BL), HGBCLs and germinal centre-derived diffuse large lym-phoma, not otherwise specified (GCB-DLBCL-NOS). Since microRNA expression in HGBCL-11q remains unknown, we aimed to identify compare the mi-croRNA profiles HGBCL-11q, BL GCB-DLBCL-NOS. Next-generation sequencing (NGS)-based profiling of (
Burkitt-like lymphoma with 11q aberration (BLL,11q) is a new entity of germinal center (GCB)-derived, highly aggressive B-cell lymphoma. Clinically and pathomorphologically, BLL,11q resembles Burkitt (BL), but it lacks MYCrearrangements presents proximal gains distal losses in chromosome 11. In the updated 2017 WHO classification, has been recognized as provisional entity. could be promoted to definite lymphomas for this purpose necessary publish many cases possible, more molecular studies...