A5052063275- Silk-based biomaterials and applications
- Advancements in Transdermal Drug Delivery
- Insect and Arachnid Ecology and Behavior
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Electron Microscopy Techniques and Applications
- Lipid Membrane Structure and Behavior
- Silkworms and Sericulture Research
- Spectroscopy and Chemometric Analyses
- Porphyrin and Phthalocyanine Chemistry
- Wnt/β-catenin signaling in development and cancer
- Optical Imaging and Spectroscopy Techniques
- Photochemistry and Electron Transfer Studies
- Spider Taxonomy and Behavior Studies
- Cell Adhesion Molecules Research
- Crystallization and Solubility Studies
- Adhesion, Friction, and Surface Interactions
- Electron and X-Ray Spectroscopy Techniques
- Skin and Cellular Biology Research
- X-ray Diffraction in Crystallography
- Photochromic and Fluorescence Chemistry
- Essential Oils and Antimicrobial Activity
- Advanced Surface Polishing Techniques
- Surface Modification and Superhydrophobicity
- Tendon Structure and Treatment
University of Southern Denmark
2017-2023
Odense Municipality
2017
Topical therapies for chronic skin diseases suffer from a low patient compliance due to the inconvenient treatment regimens of available products. Dissolvable microneedles (MN) with modified release offer an interesting possibility increase by acting as depot in and thereby decreasing dosing frequency. Furthermore, bioavailability can be increased significantly bypassing barrier direct penetration MN into skin. In this study effect innovative dissolvable patch was assessed insertion ex vivo...
Benzofuran has been proven to be the versatile substituent for tuning optics of diketopyrrolopyrroles.
Abstract Spider silk fibres have unique mechanical properties due to their hierarchical structure and the nanoscale organization of proteins. Novel imaging techniques reveal new insights into macro- nanoscopic Major (MAS) Minor (MiS) Ampullate from pristine samples orb-web spider Nephila Madagascariensis . Untreated threads were imaged using Coherent Anti-Stokes Raman Scattering Confocal Microscopy, which revealed an outer lipid layer surrounding autofluorescent protein core, that is divided...
In this work using Coherent anti-Stokes Raman Scattering microscopy, it was possible to directly measure the time dependent, spatially resolved change in concentration of water (D2 O) intact skin tissue with a spatial resolution under 1 μm, and combined multilayer diffusion model, coefficients at different depths were extracted. The results show that varies layers throughout Stratum Corneum (SC), indicating SC is not homogeneous barrier but complicated heterogeneous structure. Interestingly,...
Spider silk's mechanical properties make it an interesting material for many industrial applications. The structure and nanoscopic organization of its proteins are the basis these qualities. In this study, emission maxima autofluorescence from protein core major minor ampullate silk fibers orb-web-weaving spider Nephila madagascariensis determined found to be 534 ± 11 547 19 nm, respectively. Molecular conformational changes during applied strain observed in both fiber types using two-photon...
Focused ion beams have recently emerged as a powerful tool for ultrastructural imaging of biological samples. In this article, we show that helium microscopy (HIM), in combination with milling, can be used to visualize the inner structure both major and minor ampullate silk fibers orb-web weaving spider Nephila madagascariensis. The internal nanofibrils were imaged pristine fibers, little or no damage sample observed. Furthermore, method cut/rupture using He+ ions combined tension is...
Abstract Desmosomes are considered one of the most important intercellular junctions with respect to mechanical strength. Therefore, their spatial distribution and structure is interest understanding both healthy diseased tissue. Previous studies have imaged desmosomes in tissue slices using transmission electron microscopy, or low-resolution confocal images, but these techniques lack ability resolve 3-dimensional desmosomes. In this work it was possible determine 3D-nanostructure single...