A5056516823- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Properties of Aromatic Compounds
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Photochemistry and Electron Transfer Studies
- Sulfur Compounds in Biology
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Axial and Atropisomeric Chirality Synthesis
- Synthetic Organic Chemistry Methods
- Photochromic and Fluorescence Chemistry
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Asymmetric Hydrogenation and Catalysis
- Oxidative Organic Chemistry Reactions
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Chemical Synthesis and Analysis
- Microbial Natural Products and Biosynthesis
- Radical Photochemical Reactions
- Supramolecular Chemistry and Complexes
- Antibiotic Resistance in Bacteria
- Organoboron and organosilicon chemistry
- Nitric Oxide and Endothelin Effects
Fundación Medina
2023
Universidad de Granada
2012-2021
Here we describe a new class of CPL switches based on oxophilic interactions between chiral sulfoxide-containing ortho-phenylene ethynylene (o-OPE) foldamers and cationic metals. These systems represent unique case combining high glum values (up to 0.7 × 10-2) quantum yields in both folded ON unfolded OFF states.
A new family of homochiral silver complexes based on carbophilic interactions with ortho-phenylene ethynylene (o-OPE) scaffolds containing up to two atoms are described. These compounds represent a unique class chirality at the metal. Chiral induction is inclusion chiral sulfoxides, which allow efficient transfer helically folded o-OPE, leading circularly polarized luminescence (CPL)- and vibrational circular dichroism (VCD)-active compounds. In presence silver(I) cations, dominate, promote...
We describe a new strategy to control the number of cyclization steps in bioinspired radical (poly)cyclizations involving epoxypolyenes containing keto units positioned along polyene chain. This approach provides an unprecedentedly straightforward access natural terpenoids with pendant unsaturated side chains. Additionally, case bi- and tricyclizations, decalins cis stereochemistry have been obtained as consequence presence ketone. The preferential formation cis-fused adducts was...
Abstract The simultaneous detection of relevant metabolites in living organisms by using one molecule introduces an approach to understanding the relationships between these healthy and deregulated cells. Fluorescent probes low toxicity are remarkable tools for this type analysis biological systems vivo. As a proof concept, different naturally occurring compounds, such as biothiols phosphate anions, were focus work. 2,4‐dinitrobenzenesulfinate (DNBS) derivative 9‐[1‐(4‐ tert...
Versatile enantiopure helical systems are described and of interest owing to their intense chiroptical responses, attractive architecture for metallosupramolecular chemistry CISS effect.
Abstract A mild method for the allylation of carbonyl compounds is presented. This methodology allows a broad range starting with allyl carbonates as pronucleophiles. Noteworthy that ketones, infrequent substrates in other related protocols, are suitable under these reaction conditions. Moreover, proceeds at room temperature use catalytic amounts both Ni and Ti catalysts. The success this strategy based on perfect match between late transition metal (nickel) radical reagent (titanium)....
Dyes with near-red emission are of great interest because their undoubted advantages for use as probes in living cells. In-depth knowledge photophysics is essential employment such dyes. In this article, the photophysical behavior a new silicon-substituted xanthene, 7-hydroxy-5,5-dimethyl-10-(o-tolyl)dibenzo[b,e]silin-3(5H)-one (2-Me TM), was explored by means absorption, steady-state, and time-resolved fluorescence. First, near-neutral pH, ground-state acidity constant dye, pKN-A,...
New N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)-ethane-1,2-diamine derivatives bearing covalently linked OH and (CO)NH groups have been synthesized. The coordination of those pendant hydroxyl/amide to a Fe(ii) metal center is demonstrated both in solution, even the presence chloride as counterion, solid state, by means X-ray diffraction crystal structures. As result this coordination, experimental bond dissociation free energies (BDFE) O-H (CO)N-H bonds are remarkably diminished down 76.0 80.5...
Abstract A xanthene derivative, Granada Green dinitrobenzene sulfonate (GGDNBS), has been synthesized to assay cellular oxidative stress based on changes in the concentration of biothiols. The dye is able react with biological thiols by a thiolysis reaction that promotes change fluorescence intensity. To demonstrate usefulness GGDNBS for vivo measurements, 661 W photoreceptor-derived cells were exposed light induce ROS generation, and measured. In these cells, was correlated biothiol levels...
The full stereochemistry of telomycin, an exciting nonribosomal cyclic depsipeptide antibiotic, has been corrected by phylogeny-based bioinformatic analysis its peptide synthetases sequence and rigorous chiral amino acid analysis.
Fluorophores of the acridone family have been widely employed in many applications, such as DNA sequencing, detection biomolecules, and monitoring enzymatic systems, well being bases intracellular sensors even antitumoral agents. They used fluorescence imaging due to their excellent photophysical properties, terms quantum yield stability. However, frequently, emission data from acridones are not easily interpretable complex excited-state dynamics. The formation π-stacking aggregates excimers...
Preferred-handed helical folding of OPEs achieved by just one chiral motif: changes in CD spectra after Ag(<sc>i</sc>) complexation.
Recently, it was proposed that the thiophene ring is capable of promoting mitochondrial accumulation when linked to fluorescent markers. As a noncharged group, presents several advantages from synthetic point view, making easier incorporate such side moiety into different molecules. Herein, we confirm general applicability group as carrier for drugs and markers based on new concept nonprotonable, transporter. We implemented this in medicinal chemistry application by developing an antitumor,...
Abstract In this paper, we describe the optical and chiroptical properties of an enantiopure multipodal ortho‐ oligophenylethynylene ( S,S,S,S) ‐ 1 presenting four chiral sulfoxide groups at extremes. The presence these together with alkynes allows coordination carbophilic Ag(I), and/or oxophilic Zn(II) cations, yielding double helical structures in way. sense, different behaviors absorption, fluorescence, ECD CPL spectra have been found depending on stoichiometry nature metal. We observed...
Recently, it was proposed that the thiophene ring is capable of promoting mitochondrial accumulation when linked to fluorescent markers. As a noncharged group, presents several advantages from synthetic point view, making easier incorporate such side moiety into different molecules. Herein, we confirm general applicability group as carrier for drugs and markers, based on new concept nonprotonable, transporters. We implemented this in medicinal chemistry application by developing an...
Abstract Several synthetic applications of the primary reaction products are described.
Abstract A mild system for the allylation of carbonyl compounds includes Ni/Ti or Pd/Ti and allyl carbonates as pronucleophiles.
Development of biomarkers analytes with interest in clinic is an important field study. In this work, we synthesized and analyzed the new fluorescent acetate-biomarker, Iso-PG. The mechanism detection acetate buffer mediated proton transfer reaction. rate constants involved were obtained, measured change fluorescence lifetime produced as a consequence presence medium. Finally, checked its potential use biomarker synthetic serum