A5073702557- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Healthcare Systems and Public Health
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Human Health and Disease
- Atherosclerosis and Cardiovascular Diseases
- Nutrition, Genetics, and Disease
- Hormonal Regulation and Hypertension
- Neurological Disease Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Health and Well-being Studies
- Thermoregulation and physiological responses
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Renal and Vascular Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Health and Mental Health
Tomsk National Research Medical Center
2022-2025
Russian Academy of Sciences
2022-2025
Aim. To assess awareness of blood pressure (BP) level, adherence to therapy and achievement target BP in residents Russian regions as part the 2023 hypertension (HTN) screening campaign. Material methods. During May 2023, 4613 participants from 23 cities Russia took screening. Participation was voluntary without restrictions on sex. All patients aged over 18 years. screening, pulse were measured three times using automatic or mechanical monitors, a questionnaire about behavioral risk...
Introduction. Chronic kidney disease (CKD) and arterial hypertension (AH), especially its resistant forms, are two closely related mutually aggravating diseases. The pathophysiology of CKD development in patients with AH is complex not limited to the negative impact hemodynamic, metabolic, neurohormonal proinflammatory factors. common pathophysiological mechanism both diseases visceral obesity, which has systemic local effects. However, aspects damage (RAH) require further study, their...
To assess the effect of renal denervation (RDN) on vascular resistance and function in patients with drug-resistant hypertension (HTN) type 2 diabetes mellitus (T2DM). Fifty-nine (mean age 60.3 ± 7.9 years, 25 men) resistant HTN [mean 24-h ambulatory blood pressure (BP) 158.0 16.3/82.5 12.7 mmHg, systolic/diastolic] T2DM HbA1c 7.5 1.5%) were included single-arm prospective study underwent RDN. Renal resistive index (RRI) derived from ultrasound Doppler; estimated glomerular filtration rate...
Hypertension remains the main risk factor of cardiovascular diseases despite improvement pharmacotherapy methods. This provides rationale for an in-depth study pathogenetic mechanisms and development new methods treatment hypertension. There is increasingly more evidence essential role immune-inflammatory disorders in pathogenesis The article reviews current state knowledge on this problem. authors provide a detailed analysis studies focusing abnormal factors cellular immunity essentially...
Introduction . Patients with resistant hypertension (RHTN) and type 2 diabetes mellitus (T2DM) are characterized by sympathetic hyperactivity. A promising method for the assessment is a measurement of erythrocyte membrane beta-adrenergic reactivity (β-ARM). However, little known about β-ARM in patients RHTN T2DM. Purpose To investigate properties erythrocytes T2DM relation to clinical, laboratory, instrumental data. Material Methods The cross-sectional study comprised 38 combined mean age...
To compare the changes in serum concentrations of matrix metalloproteinases (MMPs) and their tissue inhibitor (TIMP) to dynamics blood pressure (BP) parameters left ventricular hypertrophy (LVH) 6 months after renal denervation (RD) patients with resistant arterial hypertension (RAH) complicated coronary atherosclerosis.
Aim. To study the features of regression left ventricular hypertrophy and magnetic resonance changes cardiac fibrosis in patients with resistant hypertension (RH) 1 year after renal denervation (RDN) relation to blood pressure (BP), level high-sensitivity C-reactive protein (hsCRP), matrix metalloproteinases 2, 9 (MMP-2, MMP-9), tissue inhibitor metalloproteinase type (TIMP-1). Material methods. The included 42 true RH. mean age was 59 (51; 62) years, while half were men. All took 3 or more...
Aim. To assess the functional state of sympathetic nervous system according to β-adrenergic reactivity erythrocyte membranes (EM) in patients with refractory (rfHTN) and resistant hypertension (rHTN) relation target organ damage. Material methods. The cross-sectional comparative study included 78 uncontrolled (mean age, 57,4±9,3 years (33 men)) 24-hour blood pressure (BP) (systolic/diastolic) 160,0±18,8/88,1±17,3 mm Hg. Thirty-nine (50%) had type 2 diabetes (T2D). At baseline, were divided...
Arterial hypertension (AH) remains a global problem of modern healthcare, since, despite advances in clinical pharmacology and the use antihypertensive drugs, it continues to be major risk factor for cardiovascular complications. This necessitates more in-depth study pathogenetic mechanisms this disease development new pathogenetically based methods its treatment. Every year studies are published, results which indicate significant role autonomic imbalance pathogenesis disease. The article...
Aim. To study the informativeness of sympathetic activity markers and perirenal adipose tissue (PRAT) in assessing renal function decline patients with resistant hypertension (RH). Material methods. The included 63 RH both sexes aged 40-80 years. main group 19 chronic kidney disease (CKD). control consisted 44 without CKD. All were assessed for uric acid, blood lipid profile, beta-adrenergic reactivity erythrocyte membranes, free metanephrine normetanephrine plasma 24-hour urine. was by...
Arterial hypertension (AH) is currently considered as the main risk factor for development of atherosclerosis epicardial arteries, contributing to formation not only structural, but also functional changes in coronary vessels, including at level microcirculation. Aim : To assess influence microvascular dysfunction (CMD) hypertensive origin on significance stenoses arteries according measurements fractional flow reserve (FFR), well analyze mechanisms CMD patients with heart disease...
Aim. To evaluate the severity of coronary atherosclerosis and its association with biochemical markers fibrosis in patients artery disease (CAD) resistant hypertension (RHT). Material methods . The study included 39 CAD RHT. All underwent 24-hour blood pressure (BP) monitoring, office BP numbers were measured. Laboratory diagnostics routine tests, as well determination serum lipocalin, plasma concentration matrix metalloproteinases 2 9 (MMP-2, MMP-9), tissue inhibitor metalloproteinases-1...
Objective. To study possible correlations between the quantitative characteristics of fat depots in abdominal and perirenal regions according to magnetic resonance imaging (MRI) data with metabolic immunoinflammatory parameters, renal function, blood pressure (BP), as well anthropometric patients resistant hypertension (RH). Design methods. Sixty-three (26 men) RH aged 60 [54; 64] years who were receiving individual treatment antihypertensive medication (mean, 4,3 ± 1,1 drug per day)...
The family of matrix metalloproteinases (MMPs) involved in fibrogenesis, but the effect renal denervation (RDN) on their levels is currently insufficiently studied and highly controversial. aim study was to evaluate change MMPs inhibitors during 2 years after RDN patients with resistant hypertension (RHTN) type diabetes mellitus (DM).Forty three RHTN DM were included single-arm prospective interventional studies (protocol numbers NCT01499810 NCT02667912 ClinicalTrials.gov) (mean age 60.6 ±...
Objective. To assess the changes in subclinical MRI signs of brain damage relationship with blood pressure, proinflammatory cytokines, and endothelial function one year after renal denervation (RDN) patients resistant hypertension (RHTN) type 2 diabetes mellitus (T2DM). Material Methods. The prospective interventional study (ClinicalTrials.gov identifiers NCT02667912 NCT01499810) analyzed qualitative imaging data from 39 RHTN T2DM. All underwent 24-h ambulatory pressure monitoring (ABPM),...
Aim. To study brain magnetic resonance imaging (MRI) changes in patients with resistant hypertension (HTN) after renal denervation (RD) and its cerebral protection effectiveness. Material methods. The included 111 patients, of whom 50 were men (45%) 61 women (55%), who underwent RD. mean number antihypertensive drugs taken regularly was 4,1±1,1. All MRI 24-hour ambulatory blood pressure monitoring before denervation. data statistically processed using Statistica 10,0 software. Results. After...
Aim To study renal hemodynamics in patients with resistant arterial hypertension (RAH) combination type 2 diabetes mellitus (DM2) and to identify factors involved the increase intrarenal vascular resistance.Material methods This included 59 (25 men) RAH DM2. Mean age of was 60.3±7.9 years; 24-h blood pressure (24-BP) (systolic, diastolic, SBP/DBP) 158.0±16.3 / 82.5±12.7 mm Hg during treatment 4.3 [4.0;5.0] antihypertensive drugs; glycated hemoglobin (HbA1c) 7.5±1.5 %; estimated glomerular...
Введение. Сегодня ожирение рассматривается как сложное многофакторное заболевание, в основе которого лежит чрезмерное накопление жировой ткани не только подкожном слое, но и во внутренних органах (висцеральная жировая ткань). Ежегодно всем мире распространенность лиц с избыточной массой тела ожирением неуклонно увеличивается. Так, России за последние 40 лет число возросло 1,5 раза (31,8 %) среди женщин 4 (27,9 мужчин [1]. Развитию ожирения способствует ряд факторов: малоподвижный образ...
Aim: To assess the change in left ventricular (LV) diastolic function (DF) patients with resistant hypertension (RHTN) and type 2 diabetes mellitus (T2DM) during 6-month follow-up after renal denervation (RDN) according to echocardiography conjunction changes hemodynamic parameters. Material Methods. A single center prospective interventional study included 30 RHTN T2DM. All underwent measurement of office 24-hour blood pressure (BP), standard method an assessment LV DF. Results. At 6 months...
To identify predictors of the antihypertensive efficacy renal denervation (RDN) in patients with resistant hypertension (RHTN) and type 2 diabetes mellitus (T2DM) based on results a 12-month follow-up.The study included 56 RHTN T2DM (mean age 60.1 ± 7.9 years, 32 women, mean 24-hour (24-h) blood pressure (BP) (systolic/diastolic) 156.8 15.2/82.2 12.1 mm Hg, HbA1c 7.2 1.5%). The prospective interventional RDN (NCT02667912 NCT01499810 at ClinicalTrials.gov) enrolled all patients. Office BP...