A5054219606- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Zebrafish Biomedical Research Applications
- Osteoarthritis Treatment and Mechanisms
- Photoreceptor and optogenetics research
- Bone fractures and treatments
- Neuroendocrine regulation and behavior
- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
- Connective tissue disorders research
- Medical and Biological Sciences
- Periodontal Regeneration and Treatments
University of Calgary
2019-2025
Alberta Bone and Joint Health Institute
2019-2022
John Wiley & Sons (United States)
2019
Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic behaviors remain unclear. This study investigated dopamine-induced rhythms in isolated neonatal mouse spinal cords to understand these mechanisms. The were generally synchronous and propagated rostro-caudally, although occasional asynchrony was observed. Electrical stimulation of L5 dorsal root entrained suggesting afferent control a distributed network. Even after transection or ventrolateral funiculus (VLF)...
Abstract Aggrecan is a critical component of the extracellular matrix all cartilages. One early hallmarks osteoarthritis (OA) loss aggrecan from articular cartilage followed by degeneration tissue. Mesenchymal progenitor cell (MPC) populations in joints, including those synovium, have been hypothesized to play role maintenance and/or repair cartilage, however, mechanism which this may occur unknown. In current study, we uncovered that secreted synovial MPCs healthy joints yet accumulates...
Proteoglycan 4 (PRG4) is a mucin-like glycoprotein important for joint health. Mice lacking Prg4 demonstrate degeneration of the cartilage and altered skeletal morphology. The purpose this study was to examine if deficiency leads subchondral bone defects these could be mitigated through intra-articular injection recombinant human PRG4 (rhPRG4). deficient in expression demonstrated increased thickness porosity compared with C57BL/6 controls. While Prg4-/- mice decreased over time maturation,...
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns rhythmic activity. Variation in excitability state neuromodulatory tone can facilitate transitions between rhythms; however, the intrinsic mechanisms that govern these rhythms their are poorly understood. Here, we tested capacity single central pattern generator (CPG) circuit with tunable properties to generate multiple outputs. To address this, deployed computational model...
Summary Spinal circuits produce diverse motor outputs that coordinate the rhythm and pattern of locomotor movements. Despite episodic nature these behaviours, neural mechanisms encoding episodes are not well understood. This study investigated producing rhythms evoked by dopamine in isolated neonatal mouse spinal cords. Dopamine-induced were primarily synchronous propagated rostro-caudally across segments, with occasional asynchronous episodes. Electrical stimulation L5 dorsal root could...
Abstract Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns rhythmic activity. Variation in excitability state neuromodulatory tone can facilitate transitions between rhythms; however, the intrinsic mechanisms that govern these rhythms their are poorly understood. Here, we tested capacity single central pattern generator (CPG) circuit with tunable properties to generate multiple outputs. To address this, deployed computational...