A5008344008- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Neuroscience and Neural Engineering
- Sleep and Wakefulness Research
- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Spinal Cord Injury Research
- Sleep and related disorders
- Neuroendocrine regulation and behavior
- Nerve injury and regeneration
- Neonatal and fetal brain pathology
University of Calgary
2017-2025
Allen Institute for Brain Science
2023
Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic behaviors remain unclear. This study investigated dopamine-induced rhythms in isolated neonatal mouse spinal cords to understand these mechanisms. The were generally synchronous and propagated rostro-caudally, although occasional asynchrony was observed. Electrical stimulation of L5 dorsal root entrained suggesting afferent control a distributed network. Even after transection or ventrolateral funiculus (VLF)...
Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns rhythmic activity. Variation in excitability state neuromodulatory tone can facilitate transitions between rhythms; however, the intrinsic mechanisms that govern these rhythms their are poorly understood. Here, we tested capacity single central pattern generator (CPG) circuit with tunable properties to generate multiple outputs. To address this, deployed computational model...
Spontaneous activity is a common feature of immature neuronal networks throughout the central nervous system and plays an important role in network development consolidation. In postnatal rodents, spontaneous spinal cord exhibits complex, stochastic patterns that have historically proven challenging to characterize. We developed software tool for quickly automatically characterizing classifying episodes generated from developing networks. recorded vitro lumbar ventral roots 16 neonatal...
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a dopamine-containing area medial zona incerta (mZI) that has shown relative preservation in PD models. The identified project mesencephalic locomotor region (MLR), with subpopulation cells displaying activity correlating movement speed, suggesting its involvement...
<h3>Abstract</h3> The role of orexin during development, and especially in terms spinal cord function, is not well understood. It for this reason that we focused on the network actions first week development. We found orexinergic fibers were present lumbar postnatal day 0 (P0) to P3 mice. expressed mainly dorsal horn, but occasional observed ventral horn. Both (OX) A OXB increased motoneurons (MNs) tonic neurogram discharge. However, only OXA was significantly increase spontaneous bursting...
ABSTRACT Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a heterogeneous region medial zona incerta (mZI) containing dopaminergic, GABAergic, glutamatergic neurons that has shown relative preservation in PD models. The identified project mesencephalic locomotor (MLR), with subpopulation cells displaying activity...
Summary Spinal circuits produce diverse motor outputs that coordinate the rhythm and pattern of locomotor movements. Despite episodic nature these behaviours, neural mechanisms encoding episodes are not well understood. This study investigated producing rhythms evoked by dopamine in isolated neonatal mouse spinal cords. Dopamine-induced were primarily synchronous propagated rostro-caudally across segments, with occasional asynchronous episodes. Electrical stimulation L5 dorsal root could...
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a dopamine-containing area medial zona incerta (mZI) that has shown relative preservation in PD models. The identified project mesencephalic locomotor region (MLR), with subpopulation cells displaying activity correlating movement speed, suggesting its involvement...
Abstract Developing spinal motor networks produce a diverse array of outputs, including episodic and continuous patterns rhythmic activity. Variation in excitability state neuromodulatory tone can facilitate transitions between rhythms; however, the intrinsic mechanisms that govern these rhythms their are poorly understood. Here, we tested capacity single central pattern generator (CPG) circuit with tunable properties to generate multiple outputs. To address this, deployed computational...