A5068051079- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Neuroscience of respiration and sleep
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Sleep and Wakefulness Research
- Nerve injury and regeneration
- Neonatal and fetal brain pathology
- Spinal Cord Injury Research
- Sleep and related disorders
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
University of Calgary
2017-2020
Emory University
2018
Centre National de la Recherche Scientifique
2005-2011
Aix-Marseille Université
2007-2011
Friedrich Miescher Institute
2010
Délégation Provence et Corse
2006
Abstract Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in striatum that express D 1 2 receptors respectively. The spinal cord also expresses all dopamine receptors; however, how specific network output mammals poorly understood. We explore receptor-specific mechanisms underlie dopaminergic neonatal mice during changes excitability. During spontaneous activity, which a characteristic developing networks operating low excitability...
The inhibitory action of glycine and GABA in adult neurons consists both shunting incoming excitations moving the membrane potential away from (AP) threshold. By contrast, immature neurons, postsynaptic potentials (IPSPs) are depolarizing; it is generally accepted that, despite their depolarizing action, these IPSPs because Cl(-) conductance increase. Here we investigated integration (dIPSPs) with excitatory inputs neonatal rodent spinal cord by means intracellular recordings lumbar...
GABA and glycine are excitatory in the immature spinal cord become inhibitory during development. The shift from depolarizing to hyperpolarizing postsynaptic potentials (IPSPs) occurs perinatal period rat, a time window which projections brain stem reach lumbar enlargement. In this study, we investigated effects of suppressing influences on motoneurons critical for negative reversal potential IPSPs ( E IPSP ). was transected at thoracic level day birth [postnatal 0 (P0)]. , P4–P7,...
Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in diencephalon that control locomotion is not well known. The A11 region, within posterior has been postulated to contribute function and pain. Here we show region initiates movement. Photostimulation channelrhodopsin 2 (ChR2) transfected neurons slice preparations showed could follow stimulation at frequencies 20 Hz. Our data...
Spontaneous activity is observed in most developing neuronal circuits, such as the retina, hippocampus, brainstem and spinal cord. In cord, spontaneous important for generating embryonic movements critical proper development of motor axons, muscles synaptic connections. A bursting can be recorded vitro from ventral roots during perinatal development. The depolarizing action inhibitory amino acids γ-aminobutyric acid glycine widely proposed to contribute several immature systems. During...
Maturation of inhibitory postsynaptic transmission onto motoneurons in the rat occurs during perinatal period, a time window which pathways arising from brainstem reach lumbar enlargement spinal cord. There is developmental switch miniature IPSCs (mIPSCs) predominantly long-duration GABAergic to short-duration glycinergic events. We investigated effects complete neonatal [postnatal day 0 (P0)] cord transection (SCT) on expression Glycine and GABA A receptor subunits (GlyR R subunits)...
The trunk plays a pivotal role in limbed locomotion. Yet, little is known about how the brain stem controls activity during walking. In this study, we assessed spatiotemporal patterns of axial and hindlimb motoneurons (MNs) drug-induced fictive locomotor-like (LLA) an isolated stem-spinal cord preparation neonatal mouse. We also evaluated extent to which these are affected by removal stem. Recordings were made segments T7, L2, L5 using calcium imaging from individual MNs medial motor column...
<h3>Abstract</h3> The role of orexin during development, and especially in terms spinal cord function, is not well understood. It for this reason that we focused on the network actions first week development. We found orexinergic fibers were present lumbar postnatal day 0 (P0) to P3 mice. expressed mainly dorsal horn, but occasional observed ventral horn. Both (OX) A OXB increased motoneurons (MNs) tonic neurogram discharge. However, only OXA was significantly increase spontaneous bursting...
Abstract Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in striatum that express D 1 2 receptors respectively. The spinal cord also expresses all dopamine however; how specific network output mammals poorly understood. We explore receptor-specific mechanisms underlie dopaminergic neonatal mice during changes excitability. During spontaneous activity, which a characteristic developing networks operating low excitability state, we...