A5045670792- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Neuroscience of respiration and sleep
- Nerve injury and regeneration
- Artificial Intelligence in Healthcare and Education
- Neurogenesis and neuroplasticity mechanisms
- Healthcare Systems and Public Health
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Healthcare and Venom Research
- Genetic Neurodegenerative Diseases
- Peroxisome Proliferator-Activated Receptors
- Sleep and Wakefulness Research
- AI in cancer detection
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 diagnosis using AI
- Heat shock proteins research
- Neural dynamics and brain function
- Hereditary Neurological Disorders
- Artificial Intelligence in Healthcare
- Neuroblastoma Research and Treatments
Allen Institute for Brain Science
2019-2023
University of Calgary
2014-2023
University of Alberta
2021
Ontario Brain Institute
2017
Artificial intelligence (AI) is no longer a futuristic concept; it increasingly being integrated into health care. As studies on attitudes toward AI have primarily focused physicians, there need to assess the perspectives of students across care disciplines inform future curriculum development.This study aims explore and identify gaps in knowledge that Canadian regarding AI, capture how different fields differ their present student-identified ways literacy may be incorporated curriculum.The...
Abstract Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in striatum that express D 1 2 receptors respectively. The spinal cord also expresses all dopamine receptors; however, how specific network output mammals poorly understood. We explore receptor-specific mechanisms underlie dopaminergic neonatal mice during changes excitability. During spontaneous activity, which a characteristic developing networks operating low excitability...
Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in diencephalon that control locomotion is not well known. The A11 region, within posterior has been postulated to contribute function and pain. Here we show region initiates movement. Photostimulation channelrhodopsin 2 (ChR2) transfected neurons slice preparations showed could follow stimulation at frequencies 20 Hz. Our data...
Significance Regeneration and full behavioral recovery after injury to human peripheral nerves are often incomplete. To identify factors that could improve this situation, we focused on alphaB-crystallin (αBC), a small heat shock protein has been associated with survival differentiation of glial cells as well neuroprotection in the central nervous system. We report αBC, which is expressed by both axons Schwann cells, important for remyelination damaged, mice. Its absence resulted thinner...
Regenerative capacity of injured peripheral nerves is diminished with aging. To identify factors that contribute to this impairment, we compared the immune cell response in young versus aged animals following nerve injury. First, confirmed macrophage accumulation delayed which due defects monocyte migration as a result site-specific recruitment signals nerve. Interestingly, impairment both and functional recovery could be overcome by transplanting bone marrow from into mice. That is, upon...
Abstract Spinal cord injury and peripheral nerve injuries are traumatic events that greatly impact quality of life. One factor is being explored throughout patient care the idea diet role it has on outcomes. But effects following neurotrauma need to be carefully in animal models ensure they have beneficial effects. The ketogenic provides sufficient daily caloric requirements while potentially neuroprotective analgesic. In this study, animals were fed a high-fat, low-carbohydrate led high...
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a dopamine-containing area medial zona incerta (mZI) that has shown relative preservation in PD models. The identified project mesencephalic locomotor region (MLR), with subpopulation cells displaying activity correlating movement speed, suggesting its involvement...
<h3>Abstract</h3> The role of orexin during development, and especially in terms spinal cord function, is not well understood. It for this reason that we focused on the network actions first week development. We found orexinergic fibers were present lumbar postnatal day 0 (P0) to P3 mice. expressed mainly dorsal horn, but occasional observed ventral horn. Both (OX) A OXB increased motoneurons (MNs) tonic neurogram discharge. However, only OXA was significantly increase spontaneous bursting...
ABSTRACT Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a heterogeneous region medial zona incerta (mZI) containing dopaminergic, GABAergic, glutamatergic neurons that has shown relative preservation in PD models. The identified project mesencephalic locomotor (MLR), with subpopulation cells displaying activity...
Abstract Parkinson’s disease (PD) is a complex affecting many facets of movement, especially gait abnormalities such as shuffling and freezing gait. The nigrostriatal pathways the basal ganglia are traditionally targeted by existing therapies; however, other may be more relevant to gait, pedunculopontine nucleus zona incerta (ZI). A13 target it has emerged an area interest in dopamine motor function. Yet, this remains understudied compared nuclei, animal models PD. In 6-OHDA mice, we found...
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a dopamine-containing area medial zona incerta (mZI) that has shown relative preservation in PD models. The identified project mesencephalic locomotor region (MLR), with subpopulation cells displaying activity correlating movement speed, suggesting its involvement...
Abstract Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in striatum that express D 1 2 receptors respectively. The spinal cord also expresses all dopamine however; how specific network output mammals poorly understood. We explore receptor-specific mechanisms underlie dopaminergic neonatal mice during changes excitability. During spontaneous activity, which a characteristic developing networks operating low excitability state, we...
<sec> <title>BACKGROUND</title> Artificial intelligence (AI) is no longer a futuristic concept; it increasingly being integrated into health care. As studies on attitudes toward AI have primarily focused physicians, there need to assess the perspectives of students across care disciplines inform future curriculum development. </sec> <title>OBJECTIVE</title> This study aims explore and identify gaps in knowledge that Canadian regarding AI, capture how different fields differ their present...