A5004305074- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- COVID-19 and Mental Health
- Suicide and Self-Harm Studies
- Eating Disorders and Behaviors
- Mental Health Treatment and Access
- Genetic Neurodegenerative Diseases
- Nerve injury and regeneration
University of Calgary
2021-2024
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a dopamine-containing area medial zona incerta (mZI) that has shown relative preservation in PD models. The identified project mesencephalic locomotor region (MLR), with subpopulation cells displaying activity correlating movement speed, suggesting its involvement...
ABSTRACT Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a heterogeneous region medial zona incerta (mZI) containing dopaminergic, GABAergic, glutamatergic neurons that has shown relative preservation in PD models. The identified project mesencephalic locomotor (MLR), with subpopulation cells displaying activity...
Objective: This study aimed to generate recommendations regarding how identify, prevent and respond suicide thoughts behaviors among post-secondary students. Methods: A convergent mixed-methods design with Nominal Groups Technique (NGT) was used. Post-secondary high-school students their caregivers generated ranked recommendations. Codebook Thematic Analysis approach guided analysis of the NGT-discussions extended understanding Results: 88 individuals participated in 21 panels. Five key were...
Abstract Parkinson’s disease (PD) is a complex affecting many facets of movement, especially gait abnormalities such as shuffling and freezing gait. The nigrostriatal pathways the basal ganglia are traditionally targeted by existing therapies; however, other may be more relevant to gait, pedunculopontine nucleus zona incerta (ZI). A13 target it has emerged an area interest in dopamine motor function. Yet, this remains understudied compared nuclei, animal models PD. In 6-OHDA mice, we found...
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a dopamine-containing area medial zona incerta (mZI) that has shown relative preservation in PD models. The identified project mesencephalic locomotor region (MLR), with subpopulation cells displaying activity correlating movement speed, suggesting its involvement...