A5062926374- Graphite, nuclear technology, radiation studies
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Neuroscience and Neural Engineering
- Viral Infections and Immunology Research
- Nuclear Structure and Function
- Multiple Sclerosis Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
University of Saskatchewan
2022-2024
Cameco (Canada)
2022-2024
Neurodegeneration, the progressive loss or damage to neurons and axons, underlies permanent disability in multiple sclerosis (MS); yet its mechanisms are incompletely understood. Recent data indicates autoimmunity several intraneuronal antigens, including RNA binding protein (RBP) heterogenous nuclear ribonucleoprotein A1 (hnRNP A1), as contributors neurodegeneration. We previously showed that addition of anti-hnRNP antibodies, which target same immunodominant domain MS IgG, mice with...
ABSTRACT Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which difficult to treat effectively. This study explores the therapeutic potential of targeting A13 region, a heterogeneous region medial zona incerta (mZI) containing dopaminergic, GABAergic, glutamatergic neurons that has shown relative preservation in PD models. The identified project mesencephalic locomotor (MLR), with subpopulation cells displaying activity...
Changes in nuclear morphology, alterations to the pore complex (NPC), including loss, aggregation, and dysfunction of nucleoporins (Nups), nucleocytoplasmic transport (NCT) abnormalities have become hallmarks neurodegenerative diseases. Previous RNA sequencing data utilizing knockdown heterogeneous ribonucleoprotein A1 (hnRNP A1) identified enrichment for pathways changes RNAs related morphology showed differential expression key targets. This suggests that hnRNP A1, which is observed...