A5062935663- Venomous Animal Envenomation and Studies
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Healthcare and Venom Research
- T-cell and B-cell Immunology
- Exercise and Physiological Responses
- Immune cells in cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Marine Invertebrate Physiology and Ecology
- vaccines and immunoinformatics approaches
- Ethics in Clinical Research
- Porphyrin Metabolism and Disorders
- Neonatal Health and Biochemistry
- Pregnancy and preeclampsia studies
- Tuberculosis Research and Epidemiology
- Antimicrobial Peptides and Activities
- Fibroblast Growth Factor Research
- Invertebrate Immune Response Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Mosquito-borne diseases and control
- Entomological Studies and Ecology
- Heat shock proteins research
Czech Academy of Sciences, Institute of Molecular Genetics
2023-2025
Instituto Butantan
2018-2024
Czech Academy of Sciences
2023-2024
Microsoft (Brazil)
2018
Universidade de São Paulo
2018
Centro de Excelência em Bioinformática
2018
Dermonecrosis resulting from Loxosceles spider envenomation, primarily driven by the enzyme sphingomyelinase D (SMase D), is characterized severe inflammation and nonhealing wounds. SMases can be classified as Class I or II based on their structural characteristics. exhibits greater dermonecrotic activity than II; however, intracellular mechanisms responsible for this difference remain poorly understood. The differential transcriptomics analysis of human keratinocytes treated with each toxin...
Skeletal muscle regeneration after injury is a complex process involving inflammatory signaling and myoblast activation. Pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) are key mediators, but their effects on gene expression in proliferating myoblasts unclear. We performed the RNA sequencing of TNF-α treated C2C12 to elucidate pathways networks regulated by during proliferation. The (10 ng/mL) treatment cells led 958 differentially expressed genes compared controls....
Abstract We have investigated Amblyomin-X-treated horse melanomas to better understand its mode of action through transcriptome analysis and the in vivo model. Amblyomin-X is a Kunitz-type homologous protein that selectively leads death tumor cells via ER stress apoptosis, currently under investigation as new drug candidate for cancer treatment. Melanomas are immunogenic tumors, understanding immune responses warranted. Equine spontaneous not so aggressive human are, this study shows...
Tuberculosis (TB) is one of the top 10 leading causes death worldwide. The recombinant BCG strain expressing genetically detoxified A subunit thermolabile toxin from Escherichia coli (LTAK63) adjuvant (rBCG-LTAK63) has previously been shown to confer superior protection and immunogenicity compared in a murine TB infection model. To further investigate immunological mechanisms induced by rBCG-LTAK63, we evaluated immune responses BCG, Mycobacterium tuberculosis (Mtb) H37Rv strains...
Pararamosis is a disease that occurs due to contact with the hairs of larval stage Brazilian moth Premolis semirufa. Envenomation induces osteoarticular alterations cartilage impairment resembles joint synovitis. Thus, toxic venom present in caterpillar interferes phenotype cells joints, resulting inflammation and promoting tissue injury. Therefore, address inflammatory mechanisms triggered by envenomation, we studied effects P. semirufa hair extract on human chondrocytes. We have selected...
Snake envenomation is a neglected tropical disease. In Brazil, the Bothrops genus responsible for about 86% of snakebite accidents. Despite extensive evidence cytotoxicity snake venoms, cellular and molecular mechanisms involved are not fully understood, especially regarding effects on cell cycle progression cytoskeleton organization. Traditionally, effectiveness quality control tests venoms antivenoms assessed by in vivo assays. this, there rising effort to develop surrogate vitro models...
Introduction Fibroblast growth factor 20 (Fgf20), a member of the Fgf9 subfamily, was identified as an important regulator bone differentiation and homeostasis processes. However, role Fgf20 in physiology has not been approached yet. Here we present comprehensive phenotype analysis mice with functional ablation Fgf20. Methods The study conducts extensive knockout compared to controls, incorporating microCT scanning, volumetric analysis, subfamily expression stimulation experiment...
Pertussis continues to pose a significant threat despite the availability of effective vaccines. The challenge lies in vulnerability infants who have not yet completed their vaccination schedule and adolescents adults becoming potential disease carriers.
Background: Pertussis continues to pose a significant threat despite the availability of effective vaccines. The challenge lies in vulnerability infants who have not yet completed their vaccination schedule and adolescents adults becoming potential disease carriers.Methods: We evaluated seroprevalence pertussis immunity cohort 1,500 healthy Brazilian volunteers. Next, we explored restoration waning by administering booster doses wP, aP or Plow (an economically viable low reactogenic vaccine...
Topic: 23. Hematopoiesis, stem cells and microenvironment Background: The emergence of blood during mammalian embryonic development occurs in three independent waves different origin. Importantly, the first emerge extra Yolk-sac (YS). YS provides embryo with primitive erythrocytes (EryP, wave 1) shortly after erythro-myeloid progenitors (EMPs, 2). Both YS-derived hematopoietic are essential for development. Later on, (HSCs, 3), originate aorta-gonado-mesonephros region proper. EMPs...
Introduction: Identification of factors involved in early stages left ventricular systolic function recovery after acute myocardial infarction (AMI) can provide a basis for novel therapies. We aimed to characterize proteomic biomarkers and underlying mechanistic pathways associated with improvement function. Hypothesis: Proteomic protein-protein interaction differ between patients without AMI. Methods: Patients ejection fraction (EF) <40% at hospital discharge were selected from...