A5071131078- Mitochondrial Function and Pathology
- Coenzyme Q10 studies and effects
- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Photosynthetic Processes and Mechanisms
- ATP Synthase and ATPases Research
- Parasites and Host Interactions
- Vitamin C and Antioxidants Research
- Biochemical Acid Research Studies
- Electron Spin Resonance Studies
- Essential Oils and Antimicrobial Activity
- Adipose Tissue and Metabolism
- Insect Pest Control Strategies
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- Occupational and environmental lung diseases
- Advanced battery technologies research
- Bioactive Compounds and Antitumor Agents
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cardiac Ischemia and Reperfusion
- Photochemistry and Electron Transfer Studies
- Aluminum toxicity and tolerance in plants and animals
University of Veterinary Medicine Vienna
2015-2024
Institute of Post Graduate Medical Education and Research
2018
Institute of Pharmacology
2001-2012
University of Veterinary Medicine
2010
Instituto de Medicina Tropical “Pedro Kourí”
2010
BOKU University
2007-2009
University of Vienna
1997-2007
University of Pisa
2007
Allgemeine Unfallversicherungsanstalt
2006
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2006
Immune cells are somewhat unique in that activation responses can alter quantitative phenotypes upwards of 100,000-fold. To date little is known about the metabolic adaptations necessary to mount such dramatic phenotypic shifts. Screening for novel regulators macrophage activation, we found nonprotein kinases glucose metabolism among most enriched classes candidate immune modulators. We find one these, carbohydrate kinase-like protein CARKL, rapidly downregulated vitro and vivo upon LPS...
Abstract BACKGROUND: The commercial development of plants as sources antioxidants that can be used to enhance the properties foods, for nutritional purposes and preservation well prevention oxidation‐related diseases, is currently major interest. Rosehip ( Rosa canina L.) a rich source vitamin C polyphenols. RESULTS: Phytochemicals in rosehip tea were separated into three fractions: Fr1 (vitamin C, 39.17 mg kg −1 ), Fr2 (flavonoids, 451.05 µg ) Fr3 (phenolic acids, 504.69 ). Quercetin...
// Wolfgang Warsch 1,* , Eva Grundschober Angelika Berger 1 Lars Gille Sabine Cerny-Reiterer 2,3 Anca-Sarmiza Tigan Andrea Hoelbl-Kovacic Peter Valent Richard Moriggl 4 & Veronika Sexl Institute of Pharmacology and Toxicology, Veterinary University Vienna, Veterinaerplatz 1, 1210 Austria 2 Department Internal Medicine I, Division Hematology Hemostaseology, Medical Vienna (MUV), 3 Ludwig Boltzmann Cluster Oncology, for Cancer Research (LBI-CR), * Denotes equal contribution Correspondence:...
Mitochondrial functions include production of energy, activation programmed cell death, and a number specific tasks, e.g., signaling, control Ca2+ metabolism, synthesis important biomolecules. As proper mitochondrial function is critical for normal performance survival cells, dysfunction often leads to pathological conditions resulting in various human diseases. Recently has been linked multiple organ failure (MOF) leading the death care patients. However, there are two main reasons why this...
The generation of oxygen radicals in biological systems and their sites intracellular release have been subject numerous studies the last decades. Based on these mitochondria are considered to be major source radicals. Although this finding is more or less accepted, mechanism univalent reduction still obscure. One most critical electron transfer steps respiratory chain bifurcation at cytochrome bc 1 complex. Recent with genetically mutated made it clear that from ubiquinol complex requires...
Ubiquinone is inhomogenously distributed in subcellular biomembranes. Apart from mitochondria, where ubiquinone has bioenergetic and pathophysiological functions, unusually high levels of have also been reported Golgi vesicles lysosomes. In lysosomes, the interior differs other organelles its low pH value which important to ensure optimal activity hydrolytic enzymes. Since redox-cycling associated with acceptance release protons, we assumed that part a redox chain contributing unilateral...
Abstract The molecular mechanism of the anthracycline-dependent development cardiotoxicity is still far from being clear. However, it generally accepted, that mitochondria play a significant role in triggering this organ specific injury. results presented study demonstrate that, contrast to liver mitochondria, isolated heart shuttle single electrons adriamycin, giving rise oxygen radical formation via autoxidation adriamycin semiquinones. This one electron reduction anthracyclines catalyzed...
Chromanol-type compounds act as antioxidants in biological systems by reduction of oxygen-centered radicals. Their efficiency is determined the reaction rate constants for primary antioxidative well disproportionation and recycling reactions antioxidant-derived We studied kinetics three novel chromanols: cis- trans-oxachromanol dimeric twin-chromanol, ubichromanol ubichromenol, comparison to α-tocopherol pentamethylchromanol. The radicals were identified optical electron spin resonance...