A5100404901- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Ubiquitin and proteasome pathways
- Spondyloarthritis Studies and Treatments
- Cervical and Thoracic Myelopathy
- Pregnancy-related medical research
- Retinoids in leukemia and cellular processes
- Nutrition and Health in Aging
- Macrophage Migration Inhibitory Factor
- Estrogen and related hormone effects
- Aortic aneurysm repair treatments
- Hip and Femur Fractures
- Abdominal vascular conditions and treatments
- Bone Metabolism and Diseases
- Shoulder Injury and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Health Systems, Economic Evaluations, Quality of Life
- S100 Proteins and Annexins
- Scoliosis diagnosis and treatment
- Sarcoma Diagnosis and Treatment
- Frailty in Older Adults
- Ferroptosis and cancer prognosis
- Pain Mechanisms and Treatments
Second Affiliated Hospital of Zhejiang University
2014-2023
Beijing Jishuitan Hospital
2020-2021
Peking University
2020-2021
First Affiliated Hospital of Nanchang University
2017
Nanchang University
2017
Zhejiang University
2009-2014
Jiangsu Province Hospital
2008
Nanjing Medical University
2008
Chemokine C-C motif ligand 7 (CCL7), a member of CC chemokine subfamily, plays pivotal roles in numerous inflammatory diseases. Hyper-activation inflammation is an important characteristic abdominal aortic aneurysm (AAA). Therefore, the present study, we aimed to determine effect CCL7 on AAA formation. abundance tissue and macrophage infiltration were both increased angiotensin II (Ang II)-induced mice. Ex vivo, promoted polarization towards M1 phenotype. This was reversed by blockage CCR1,...
Cardiac dysfunction is a common complication of sepsis with high mortality. The present study was designed to identify the effect neutrophil-derived lipocalin-2 (LCN2) in septic cardiac (SCD) and its potential mechanism. Wild-type (WT) LCN2-knockout (LCN2 KO) mice were peritoneally injected lipopolysaccharide (LPS) induce SCD. function assessed 12 h after LPS injection by echocardiography. tissue harvested for evaluation malonaldehyde (MDA) prostaglandin E synthase 2 (PTGS2) mRNA levels....
All-trans retinoic acid (ATRA) is a widely used differentiation drug that can effectively induce osteogenic of osteosarcoma cells, but the underlying mechanism remains elusive, which limits clinical application for ATRA in patients. In this study, we identified E2F1 as novel regulator involved ATRA-induced cells. We observed cells are coupled with individual differences expression levels patients, and impairs Moreover, remarkable anti-proliferative differentiation-inducing effects treatment...
The role and mechanism of pyroptosis in intervertebral disc (IVD) degeneration are unclear. MicroRNAs (miRNAs) regulate the viability function nucleus pulposus cells (NPCs) IVDs related to pyroptosis. We performed microarray analyses normal degenerated NP assess identify key miRNAs IVD degeneration. also evaluated underlying miRNA-mediated NPCs. In addition, we demonstrated preventative effects on a rat model. levels pyroptosis-related proteins cleaved caspase-1, N-terminal gasdermin D,...
Abstract Background Extreme lumbar spinal stenosis was thought to be a relative contraindication for lateral interbody fusion (LLIF) and excluded in most studies. This is retrospective study analyze the radiographic clinical outcome of LLIF extreme Schizas grade D. Methods For analysis, we included 181 segments from 110 patients who underwent between June 2017 December 2018. Lumbar graded according Schizas’ classification. Anterior posterior disc heights, angle, foramen height, canal...
Intervertebral disc (IVD) degeneration is associated with local inflammation and increased expression of neurotrophins. Acidic microenvironment believed to cause the progression IVD degeneration. However, there a paucity information regarding relationship between acidic neurotrophins in IVD. G‐protein‐coupled receptor 4 (GPR4) pH‐sensing receptor, which can activate increase levels nerve growth factor microenvironment. In this study, culture media pH 7.2 (representing normal IVD‐like...
To quantitatively evaluate the clinical value and demonstrate potential benefits of biochemical axial T2* mapping-based grading early stages degenerative disc disease (DDD) using 3.0-T magnetic resonance imaging (MRI) in a setting. Fifty patients with low back pain 20 healthy volunteers (control) underwent standard MRI protocols including mapping. All intervertebral discs (IVDs) were classified morphologically. Lumbar IVDs graded Pfirrmann score (I to IV). The values anterior annulus...
For patients with degenerative spondylolisthesis, whether additional posterior fixation can further improve segmental alignment is unknown, compared stand-alone cage insertion in oblique lumbar interbody fusion (OLIF) procedure. The aim of this study was to compare changes the radiographical following and same procedure setting OLIF for spondylolisthesis. A retrospective observational study. Selected consecutive spondylolisthesis underwent from July 2017 August 2019. Five radiographic...
Traumatic incarceration of the small bowel accompanied by vertebral fractures and dislocation is rare usually misdiagnosed until laparotomy. This report presents a case jejunum entrapment between lumbar spine fractures. A 43-year-old man was clamped two railway tracks on upper abdomen lower back. Following ineffective conservative treatment, he underwent laparotomy due to development guarding rebound tenderness. Loss vitality jejunal loop, which incarcerated L3 L4 vertebrae, observed. The...
Abstract Background: For patients with degenerative spondylolisthesis, whether additional posterior fixation can further improve segmental alignment is unknown, compared stand-alone cage insertion in oblique lumbar interbody fusion (OLIF) procedure. The aim of this study was to compare changes the radiographical following and same procedure setting OLIF for spondylolisthesis. Methods: A retrospective observational study. Selected consecutive spondylolisthesis underwent from July 2017 August...
Objective To study the effect of centrifugal force on construction tissue-engineered fibrous annulus in vitro. Methods The annuli were isolated by trypsin and type Ⅱ collagenase from thoracic lumbar intervertebral discs rabbits. Cells proliferated to third generation vitro seeded into PLGA scaffolds (5 × 10 /mL). experimental group was subjected force(85.86 g relative-centrifugal force, twice per day, for 15 min) while control cultured under normal condition. Each contained 5 specimens. Both...
Abstract Background: For patients with degenerative spondylolisthesis, whether additional posterior fixation can further improve segmental alignment is unknown, compared stand-alone cage insertion in oblique lumbar interbody fusion (OLIF) procedure. The aim of this study was to compare changes the radiographical following and same procedure setting OLIF for spondylolisthesis. Methods: A retrospective observational study. Selected consecutive spondylolisthesis underwent from July 2017 August...