A5009072230- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Management of metastatic bone disease
- Luminescence and Fluorescent Materials
- Covalent Organic Framework Applications
- Spine and Intervertebral Disc Pathology
- Image Processing Techniques and Applications
- Hip and Femur Fractures
- Electrospun Nanofibers in Biomedical Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Cytokine Signaling Pathways and Interactions
- Radio Wave Propagation Studies
- Autophagy in Disease and Therapy
- Optical Wireless Communication Technologies
- Cancer-related Molecular Pathways
- FOXO transcription factor regulation
- Periodontal Regeneration and Treatments
Second Affiliated Hospital of Zhejiang University
2015-2025
Zhejiang University
2011-2024
Zhejiang Lab
2021-2023
Zhejiang University Medical College Affiliated Stomatological Hospital
2020-2023
Air Force Medical University
2022-2023
Wuhan University
2022
Shandong University of Science and Technology
2021
Clinical Orthopaedics and Related Research
2018
Dongguan University of Technology
2017
Xidian University
2012-2013
This study aimed to describe the epidemiologic characteristics of fracture in elderly during COVID-19.This was a retrospective multi-centre study, which included patients who sustained fractures between 20 January and 19 February 2020. The collected data patients' demographics (age gender), injury-related (injury type, location, injury mechanism, places where occurred), treatment modality. SPSS 23.0 used perform some analysis.A total 436 with 453 were included; there 153 males 283 females,...
The imbalance of bone homeostasis is the root cause osteoporosis. However current therapeutic approaches mainly focus on either anabolic or catabolic pathways, which often fail to turn imbalanced metabolism around. Herein we reported that a SIRT-1 agonist mediated molecular strategy reverse in by simultaneously regulating osteogenesis and osteoclastogenesis via locally sustained release SRT2104 from mineral coated acellular matrix microparticles. Immobilization coating (MAM/SRT) harnessing...
Abstract Vascularized osteogenesis is essential for successful bone regeneration, yet its realization during large size defect healing remains challenging due to the difficulty couple multiple biological processes. Herein, harnessing intrinsic angiogenic potential of vascular derived extracellular matrix (vECM) and specific affinity growth factors, a vECM/GelMA based hybrid hydrogel delivery system constructed achieve optimized morphogenetic protein‐2 (BMP‐2) therapeutic index provide...
Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles. However, ordinary antimicrobial treatments usually failed to combat multiple waves infections arthroplasty and prosthesis revisions etc. As these incidents could easily introduce new microbial pathogens in/onto implants. Herein, we demonstrate that an trilogy strategy incorporating a sophisticated multilayered coating system leveraging ion exchange mechanisms fine...
Osteosarcoma is the most common bone cancer, and chemotherapy currently indispensable for its treatment. Adriamycin has been claimed to be effective agent osteosarcoma, however, outcome of adriamycin remains unsatisfactory. Here, we reported a potent combination therapy that bortezomib, proteasome inhibitor, enhances adriamycin-induced apoptosis eliminate osteosarcoma cells revealed activation p-eIF2α/ATF4/CHOP axis underlying associated mechanisms. First, observed bortezomib...
Abstract Forkhead box protein A2 (FOXA2) is a core transcription factor that controls cell differentiation and may have an important role in bone metabolism. However, the of FOXA2 during osteogenic marrow-derived mesenchymal stem cells (BMSCs) remains largely unknown. In this study, decreased expression was observed rat BMSCs (rBMSCs). knockdown significantly increased osteoblast-specific gene expression, number mineral deposits alkaline phosphatase activity, whereas overexpression inhibited...
All-trans retinoic acid (ATRA) is a widely used differentiation drug that can effectively induce osteogenic of osteosarcoma cells, but the underlying mechanism remains elusive, which limits clinical application for ATRA in patients. In this study, we identified E2F1 as novel regulator involved ATRA-induced cells. We observed cells are coupled with individual differences expression levels patients, and impairs Moreover, remarkable anti-proliferative differentiation-inducing effects treatment...
Low back pain (LBP) is one of the most common complains in orthopedic outpatient department and intervertebral disc degeneration (IDD) important reasons LBP. The mechanisms IDD contain a complex biochemical cascade which includes inflammation, vascular ingrowth, results degradation matrix. In our study, we used both vitro vivo models to investigate relation between tissue inhibitor metalloproteinase-3 (TIMP3) expression IDD. Loss TIMP3 was found degenerative (IVD), this change closely...
Inflammatory microenvironment is significant to the differentiation and function of mesenchymal stem cells (MSCs). It evidentially influences osteoblastogenesis MSCs. IL-34, a newly discovered cytokine, playing key role in metabolism. However, research on its functional osteogenesis MSCs was rarely reported. Here, we described regulatory effects low-dose IL-34 both osteoclastogenesis.We performed osteogenic hBMSCs by exogenous overexpressed vitro, so were osteoclastogenesis mBMMs...
A number of clinical and experimental studies have investigated the effect simvastatin on bone regeneration. In present study, release from simvastatin-loaded calcium sulphate (CS) scaffolds these osteogenic differentiation marrow-derived mesenchymal stem cells (MSCs) in vitro locally applied CS regeneration were investigated. total 26 complete 1.2-cm defects created ulna rabbits, which treated with CS, or recombinant human morphogenetic protein 2 (rhBMP)-2-loaded CS. Simvastatin was highly...
Bone mesenchymal stem cells (BMSCs) are important candidates for bone regeneration. The role of Bergenin, a C-glucoside 4-O-methyl gallic acid obtained from the species, Bergenia, in BMSC osteogenesis has not yet been elucidated. We therefore investigated effects Bergenin on BMSCs and found that enhanced osteoblast-specific markers downregulated adipocyte-specific vitro. Furthermore, using rat calvarial defect model, we significantly improved healing, as determined by imaging histological...
Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in formation. Parkin, an E3 ubiquitin ligase, related to Parkinson's disease and aging. Previous studies have indicated that higher risk osteoporotic fracture. To investigate the effects underlying mechanism Parkin osteogenic BMSCs, was analyzed following upregulation or downregulation Parkin. We found increased during differentiation. overexpression enhanced osteo-specific markers, mitigated...
The percutaneous sacroiliac (SI) screw is a common fixation option for posterior ring disruption in pelvic fractures. However, SI placement difficult and can injure adjacent neurovascular structures. sacral-alar-iliac (SAI) safe, reliable free-hand sacral technique. To investigate the biomechanical stability of SAI joint dislocation, finite element analysis was performed unstable Tile-Type B C injuries. displacement S1 (fixation unilateral segment with one screw), TS1 transsacra 1 TS2 S2 2...
Pelvic ring reconstruction after resection of pelvic malignancies or aggressive benign tumors remains challenging, especially when the tumor invades periacetabular bone, resulting in a Type II as classified by Enneking and Dunham (removal part all acetabulum). Although numerous treatment approaches are use, none is clearly superior to others. An alternative involving use ipsilateral proximal femur an autograft has not been well characterized, so we present our preliminary experience with...