The sudden outbreak of novel coronavirus has caused a global concern due to its infection rate and mortality. Despite extensive research, there are still no specific drugs or vaccines combat SARS-CoV-2 infection. Hence, this study was designed evaluate some plant-based active compounds for drug candidacy against by using virtual screening methods various computational analyses. A total 27 plant metabolites were screened main protease proteins (MPP), Nsp9 RNA binding protein, spike receptor...

In the absence of effective biological or chemical controls, melon fly poses a significant threat to food security, particularly impacting cucurbit crops in tropical and subtropical regions. Melon infestations have resulted yield losses 30 %-100 %, depending on specific species season. Current control methods using synthetic chemicals are challenging due their environmental impacts. This study identified 59 phytocompounds with potential insecticidal properties against fly, exhibiting minimal...

SARS-CoV-2 has triggered a major epidemic among people around the world, and it is newest in sequence to become prevalent other infectious diseases. The drug repurposing concept been utilized effectively for numerous viral infections. Considering situation urgency, idea of coronavirus infection (COVID-19) also being studied. molecular docking method was used screening 29 antiviral drugs against primary protease proteins (MPP) SARS-CoV-2, spike ecto-domain, receptor binding domain, Nsp9 RNA...

The COVID-19 pandemic caused by SARS-CoV-2 has been showing a speedy growth in the number of infected patients with remarkable mortality rate, thus it become worldwide public health concern. From March 8, 2020, virus started spreading Bangladesh. Since then, people got so exponentially that country positions at list top countries world. Therefore, objective this comprehensive review was representing overall scenario different sectors Because insufficient scientific publications, we chose...

The Zika virus (ZIKV) has caused a heavy concern all over the world because of its high infectivity and mortality rate. Still, there's no specific drug or preventive medication to treat ZIKV infection despite comprehensive analysis by researchers. This study was designed demonstrate efficacy some plant-derived bioactive compounds against using both structure ligand-based virtual screening methods. A total 35 plant metabolites were screened on basis their reported pharmacological activities...

This study addresses the global threat posed by White spot syndrome virus (WSSV) to aquaculture sector, causing substantial economic losses and impacting food security. The research explores a novel strategy using plant metabolites with proven antiviral properties as an eco-friendly alternative traditional chemical treatments. Employing molecular docking several bioinformatics tools, 63 are screened for their potential inhibit WSSV. Hyperoside, Quercetin, Rutin emerge top candidates,...

The monkeypox virus was still spreading in May 2022, with the first case identified a person travel ties to Nigeria. Using molecular docking-based techniques, we evaluated efficiency of different bioactive chemicals obtained from plants against virus. A total 56 plant compounds were for antimonekypox capabilities, top four candidates having higher binding affinity than control. We targeted profilin-like protein, which plays key role viral replication and assembly. Among metabolites, curcumin...

Abstract The locust problem is a global threat for food security. Locusts can fly and migrate overseas within zip creating large-scale devastation to the diversified agro-ecosystem. GIS based analysis showed recent movement of locusts, among them Schistocerca gregaria Locusta migratoria are predominant in Indian subcontinent found more notorious devastating one. This needs be stopped save human race from deprivation. In our study, we screened some commonly used agricultural pesticides...

Abstract The ZIKA virus has caused a heavy concern everywhere the globe because of its high infectivity and mortality rate. Still, there’s no specific drug or preventive medication to treat infection despite comprehensive analysis by researchers. This study was designed demonstrate efficacy some plant derived bioactive compounds against ZIKV using both structure ligand based virtual screening methods. A number 35 metabolites were screened NS2B-NS3 protease (5LC0), Envelop protein (5JHM),...

Abstract The deeper understanding of metastasis phenomenon and detection drug targets could be a potential approach to minimize cancer mortality. In this study, attempts were taken unmask novel therapeutics prevent progression. Initially, we explored the physiochemical, structural functional insights three tumor antigens (MTAs) evaluated some plant based bioactive compounds as potent MTA inhibitors. From 50 metabolites screened, isoflavone, gingerol, citronellal asiatic acid showed maximum...

Mucormycosis has become a global issue due to its potential infect and destroy organs, as well high fatality rate. Co-infecting with Covid 19 or when infecting after 19, it becomes more lethal. Several antifungal medicines have been utilized treat this illness, but they come slew of dangerous side effects. Hence, using various computational tools; the current study was attempted determine several plant metabolites that can act inhibitory agents Rhizopus oryzae, which is responsible for 70%...

The high infectivity and mortality of novel coronavirus has caused a serious concern all over the world. Still, there is no specific drug or preventive medication to treat SARS-CoV-2 infection despite comprehensive analysis by researchers. This study was designed demonstrate efficacy some phyto-chemical compounds against using both structure ligand based virtual screening methods. A total 33 plant metabolites were screened main protease proteins (MPP), Nsp9 RNA binding protein, spike...

SARS-CoV-2 has triggered a big epidemic among people around the world and it is newest in sequence to be prevalent other infectious diseases. Drug repurposing concept been utilized effectively for numerous viral infections. Considering situation urgency, idea of drug coronavirus infection (COVID-19) also being studied. Screening with molecular docking method 29 antiviral drugs was performed against SARSCoV-2 primary protease proteins (MPP), spike ecto-domain, receptor binding domain, Nsp9...

Proteins are vital for the significant cellular activities of living organisms. However, not all them essential. Identifying essential proteins through different biological experiments is relatively more laborious and time-consuming than computational approaches used in recent times. practical implementation conventional scientific methods sometimes becomes challenging due to poor performance impact specific scenarios. Thus, developed efficient prediction models required protein...

Rice blast, a severe fungal disease, is substantial threat to global food security, particularly in rice-oriented areas. The Magnaporthe oryzae fungus increasingly resistant and fast developing nature. However, chemical fungicides are not only detrimental the environment but eventually also lose their efficiency. To Tackle this issue, we used an silico based strategy identify plant metabolites as bio-fungicides combat rice blast. Therefore, screened total of 56 antifungal natural compounds...

<p>SARS-CoV-2 has triggered a big epidemic among people around the world and it is newest in sequence to be prevalent other infectious diseases. Drug repurposing concept been utilized effectively for numerous viral infections. Considering situation urgency, idea of drug coronavirus infection (COVID-19) also being studied. Screening with molecular docking method 29 antiviral drugs was performed against SARSCoV-2 primary protease proteins (MPP), spike ecto-domain, receptor binding...

The high infectivity and mortality of novel coronavirus has caused a serious concern all over the world. Still, there is no specific drug or preventive medication to treat SARS-CoV-2 infection despite comprehensive analysis by researchers. This study was designed demonstrate efficacy some phyto-chemical compounds against using both structure ligand based virtual screening methods. A total 33 plant metabolites were screened main protease proteins (MPP), Nsp9 RNA binding protein, spike...

The sudden outbreak of novel corona virus at the end 2019 has caused a global threat to mankind due its extreme infection rate and mortality. Despite extensive research, still there is no an approved drug or vaccine combat SARS-CoV-2 infections. Hence, study was designed evaluate some plant-based active compounds for candidacy against by using virtual screening methods various computational analysis. A total 27 plant metabolites were screened SARS-Cov-2 main protease proteins (MPP), Nsp9 RNA...

Abstract The Dengue virus (DENV) has caused heavy concern worldwide because of its high infectivity and mortality rate. Still, there's no specific drug or preventive medication to treat DENV infection despite comprehensive analysis by the researchers. This study was designed demonstrate efficacy some plant-derived bioactive compounds against using ligand-based virtual screening methods. A total 52 plant metabolites 74 peptides were screened on basis their reported pharmacological activities...

The occurrence of extended-spectrum beta-lactamase (ESBL) producing bacteria is concerning the scientific community since it confers multiple drug resistance (MDR). study investigated prevalence MDR-ESBL-producing Salmonella strains from shrimp in Sylhet region, Bangladesh. A total 165 samples were processed 55 specimen different retail shops. presence was confirmed by standard methods followed antibiotic susceptibility testing. Isolates exhibiting resistant to third-generation cephalosporin...