A5051462258- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Transgenic Plants and Applications
- COVID-19 Pandemic Impacts
- Chemical Synthesis and Analysis
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Natural product bioactivities and synthesis
- Bacterial Infections and Vaccines
- RNA Interference and Gene Delivery
- Machine Learning in Bioinformatics
- Antibiotic Resistance in Bacteria
- Peptidase Inhibition and Analysis
- Animal Genetics and Reproduction
- Livestock Farming and Management
- Animal Virus Infections Studies
- Bacterial Genetics and Biotechnology
- Genetic and phenotypic traits in livestock
- Evolution and Genetic Dynamics
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
Sylhet Agricultural University
2020-2024
SARS-CoV-2 has triggered a major epidemic among people around the world, and it is newest in sequence to become prevalent other infectious diseases. The drug repurposing concept been utilized effectively for numerous viral infections. Considering situation urgency, idea of coronavirus infection (COVID-19) also being studied. molecular docking method was used screening 29 antiviral drugs against primary protease proteins (MPP) SARS-CoV-2, spike ecto-domain, receptor binding domain, Nsp9 RNA...
The COVID-19 pandemic caused by SARS-CoV-2 has been showing a speedy growth in the number of infected patients with remarkable mortality rate, thus it become worldwide public health concern. From March 8, 2020, virus started spreading Bangladesh. Since then, people got so exponentially that country positions at list top countries world. Therefore, objective this comprehensive review was representing overall scenario different sectors Because insufficient scientific publications, we chose...
Nipah virus (NiV), a zoonotic virus, engenders severe infections with noticeable complications and deaths in humans animals. Since its emergence, it is frightening, this has been causing regular outbreaks various countries, particularly Bangladesh, India, Malaysia. Unfortunately, no efficient vaccine or drug available now to combat baneful virus. NiV employs nucleocapsid protein for genetic material packaging, which crucial viral replication inside the host cells. The small interfering RNAs...
Lumpy skin disease (LSD) is a fulminant infectious that mostly affects cattle and causes considerable economic loss throughout the globe. This study was conducted to develop new multi-epitope-based vaccine against LSD can elicit immunological responses using an in silico reverse vaccinology approach. Initially, three antigenic proteins, protein E5, E3 ubiquitin-protein ligase LAP 62 kDa protein, were manipulated recognize potential T-cell B-cell epitopes. To identify superior epitopes,...
POLD1 (DNA polymerase delta 1, catalytic subunit) is a protein-coding gene that encodes the large subunit (POLD1/p125) of DNA (Polδ) complex. The consequence missense or nonsynonymous SNPs (nsSNPs), which occur in coding region specific gene, replacement single amino acid. It may also change structure, stability, and/or functions protein. Mutation associated with autosomal dominant predisposition to colonic adenomatous polyps, colon cancer, endometrial cancer (EDMC), breast and brain tumors....
Abstract The deeper understanding of metastasis phenomenon and detection drug targets could be a potential approach to minimize cancer mortality. In this study, attempts were taken unmask novel therapeutics prevent progression. Initially, we explored the physiochemical, structural functional insights three tumor antigens (MTAs) evaluated some plant based bioactive compounds as potent MTA inhibitors. From 50 metabolites screened, isoflavone, gingerol, citronellal asiatic acid showed maximum...
The high infectivity and mortality of novel coronavirus has caused a serious concern all over the world. Still, there is no specific drug or preventive medication to treat SARS-CoV-2 infection despite comprehensive analysis by researchers. This study was designed demonstrate efficacy some phyto-chemical compounds against using both structure ligand based virtual screening methods. A total 33 plant metabolites were screened main protease proteins (MPP), Nsp9 RNA binding protein, spike...
SARS-CoV-2 has triggered a big epidemic among people around the world and it is newest in sequence to be prevalent other infectious diseases. Drug repurposing concept been utilized effectively for numerous viral infections. Considering situation urgency, idea of drug coronavirus infection (COVID-19) also being studied. Screening with molecular docking method 29 antiviral drugs was performed against SARSCoV-2 primary protease proteins (MPP), spike ecto-domain, receptor binding domain, Nsp9...
The scientific community has been releasing whole genomic sequences of SARS-CoV-2 to facilitate the investigation molecular features and evolutionary history. We retrieved 36 genomes 18 prevalent countries Asia, Europe America for diversity mutational analysis. Besides, we studied mutations in RBD regions Spike (S) proteins analyze drug efficiency against these mutations. In this research, phylogenenetic analysis, modeling, substitution pattern docking, dynamics simulation, etc. were...
causes whooping cough in humans that spreads directly from individual to mainly by aerosolized respiratory droplets. Nowadays, it gained the attention of scientific community because has already been reemerged as one major public health threats despite widespread vaccination efforts. Moreover, growing antibiotic resistance made difficult combat this pathogen with currently available antibiotics. Consequently, screening drug targets and discovering drugs against unique proteins could be a...
<p>SARS-CoV-2 has triggered a big epidemic among people around the world and it is newest in sequence to be prevalent other infectious diseases. Drug repurposing concept been utilized effectively for numerous viral infections. Considering situation urgency, idea of drug coronavirus infection (COVID-19) also being studied. Screening with molecular docking method 29 antiviral drugs was performed against SARSCoV-2 primary protease proteins (MPP), spike ecto-domain, receptor binding...
The high infectivity and mortality of novel coronavirus has caused a serious concern all over the world. Still, there is no specific drug or preventive medication to treat SARS-CoV-2 infection despite comprehensive analysis by researchers. This study was designed demonstrate efficacy some phyto-chemical compounds against using both structure ligand based virtual screening methods. A total 33 plant metabolites were screened main protease proteins (MPP), Nsp9 RNA binding protein, spike...
The bovine species buffalo was domesticated from its wild strain Bubalus arnee and is widely used livestock in southern Asia. There are two distinct types of Buffalo- the swamp (B. bubalis kerebau) river bubalis), which diverged Asian water then evolved separate geographical regions. Several research studies performed on buffalo, like- characterization trait-specific Single Nucleotide Polymorphism (SNP), genetic phenotypic diversity, gene prediction function annotation, mapping draft genome,...
Abstract Phenotypically similar to B. subtilis, Bacillus atrophaeus is a Gram-positive, aerobic, spore-forming bacteria. It black-pigmented bacterial genus. Therefore, it of interest study the uncharacterized proteins in genome. For detailed computational sequence-structure-function analysis using available data and resources, an protein Mta (AKL87074.1) genome was selected. In this study, attempts were made physicochemical properties, predict secondary structure, modeling 3-D protein,...