A5039315709- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Neurological Disorders and Treatments
- Muscle Physiology and Disorders
- Biochemical effects in animals
- Streptococcal Infections and Treatments
- Respiratory and Cough-Related Research
- Biofield Effects and Biophysics
- Vitamin C and Antioxidants Research
- Chemical Reactions and Isotopes
- Curcumin's Biomedical Applications
- Eicosanoids and Hypertension Pharmacology
- Long-Term Effects of COVID-19
- Biochemical Acid Research Studies
- Infant Health and Development
- Spaceflight effects on biology
- TGF-β signaling in diseases
- Pediatric health and respiratory diseases
- GDF15 and Related Biomarkers
- COVID-19 Clinical Research Studies
- Human Health and Disease
- Medicinal Plants and Bioactive Compounds
- Bacteriophages and microbial interactions
- Antimicrobial Resistance in Staphylococcus
- Bacterial Genetics and Biotechnology
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences
2019-2025
Institute of Biomedical Chemistry
2023-2024
Sechenov University
2019-2020
The article presents the results of determining acute toxicity a nasal spray based on antigens opportunistic bacteria in two formulations: with and without prolonging agent. According to Hodge Sterner classification, when administered mice at maximum possible doses, formulations were classified as up class 4 for subcutaneous administration 3 intranasal administration. These findings support feasibility further development formulations.
The aim of the investigation was to study effect 2-ethyl-6-methyl-3-hydroxypyridine malate (Ethoxidol) on concentration oxidative stress metabolites in patients with chronic heart failure (CHF) and hypertension.126 FC I-III CHF have been examined. In addition their individual therapy these received intravenous infusions Ethoxidol. Blood content 2,3-diphosphoglycerate (2,3-DPG), oxygen tension (рО2), pH, total peroxides, lactate, aldosterone were identified. 2,3-DPG levels (g/L erythrocytes)...
РОЛЬ ОКИСЛИТЕЛЬНОГО СТРЕССА В
ABSTRACT The number of infections caused by microorganisms that are resistant to antibiotics and synthetic antibacterial drugs is growing fast worldwide. This one the most important urgent problems in health care. main efforts researchers around world focused on solving this issue. Nitrofurans represent effective classes drugs. We have synthesized 4 analogues nifuroxazide – a well known nitrofuran antibiotic confirmed their structures NMR, IR spectroscopy, mass-spectrometry. All obtained...
The important challenge to the biotechnology is find new effective fusion partners that enable improve solubility, expression, and optimize subsequent fine purification of target protein. most invariant part immunogenic region surface virulence factor A Streptococcus pneumoniae was selected as a model protein, while thermostable chemotaxis polypeptide W-type from Thermotoga petrophila used partner. genes encoding variants these proteins were constructed cloned into plasmid vector under...
The problems related to the development of pneumococcal vaccines require combination traditional solutions and alternative systems optimizing this procedure. Recombinant subunit have undeniable advantages over inactivated live-attenuated vaccines: they induce cell-mediated humoral immunologic responses effectively with high specificity, but without risks associated authentic pathogen processing. However, specific adjuvants enhance immune response or special fusion partners improve...
In heart attack, FSTL-1 is actively secreted by cardiomyocytes, accelerates growth of myofibrils and stimulates vascular endothelial factor expression. The aim this work was to investigate the effect Etoxidol on synthesis in rats after myocardial infarction. experiments were performed Wistar weighing 250-350 g with simulated infarction or intact (group 5). Animals control groups (groups 1, 2) treated saline for 7 14 days; Ethoxidol (24 mg/kg) injected animals experimental 3, 4) (the daily...
This study discusses the role of oxidative stress and inflammation in development severe acute respiratory syndrome (SARS) associated with COVID-19 caused by novel SARS-CoV-2 coronavirus. An analysis literature revealed that viral infections, including COVID-19, is usually accompanied accumulation acidic metabolic products blood tissues and, accordingly, increased levels cytokines. In this regard, it seems appropriate to use second-generation low-toxic antioxidant Ethoxidol, manufactured...
Objective - to study the effect of three different concentrations drug "ASD-2B drops" on growth M. tuberculosis strain № 22063. Materials and methods. The 22063 with a single addition into reaction mixture was evaluated. Cultivation carried out in Dubos broth for growing mycobacteria at 37°C 20 days periodic assessment turbidity index using densitometer. Results. concentration 750 µl 10 ml after zero point inhibited accumulation biomass M.tuberculosis compared control. lower (37.5 75 µl)...
The second fraction of antiseptic Dorogov's stimulator (ASD-2F) is a derivative raw biological materials, namely mixture products thermal protein degradation. ‘ASD-2B drops’ dietary supplement containing ASD-2F. Each component plays role in some processes living organism. ASD-2F affects the functional activity many organs and systems body increases resistance to negative factors, such as microorganisms causing various infectious diseases. development multidrug by necessitates search for new...
Background: A cellular model of oxidative stress induced by hydrogen peroxide in the primary culture myoblasts was obtained vitro experiments, and possibility exogenous regulation cytotoxic effect using 2-ethyl-6-methyl-3-hydroxypyridine malate (ethoxidol) studied. Moreover, influence ethoxidol on intracellular expression such an important biomarker as myostatin investigated. Methods: Hydrogen used to induce stress. The rate myoblast proliferation studied measuring reduction level (3-(4,5-...
Infections caused by Streptococcus pneumoniae have always been a significant challenge for healthcare worldwide. Existing diagnostic methods are not able to identify capsule-free forms of pneumococci or optochin-resistant strains that also play an important role in the development pneumococcal infections. Such limitations procedures necessitate serotype-independent tests. This review focuses on antigenic structure pneumoniae, specific characteristics teichoic and lipoteichoic acids, analyzes...
Objective: To study the cytotoxic effect of palmitic acid on myoblasts in vitro and influence this toxicant expression myostatin mRNA myoblast culture. Methods: research protective action against these processes a compound with antioxidant activity, for which 2-ethyl-6-methyl-3-hydroxypyridine malate (ethoxidol) was chosen. Results: Our studies have shown that has noticeable cytostatic vitro, significantly suppressing their proliferation: rate MTT recovery treated palmitate only 9.6% control...
The article presents the results of evaluating effect addition glucose and lecithin to culture medium (Brain Heart Infusion Broth) on rate accumulation biomass various Streptococcus pneumoniae strains: No. 3405, serotype 4 (K-4); No.16082, 14 (K-14); 3391, unstable in capsule formation (R-form). There was an increase strain 3405 (K-4) by 10% variant with lecithin; 64% elongation stationary phase 16082 (K-14) when grown glucose. growth 3391 (R-form) 37.5% extended duration occurred lecithin....