A5040729990- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Hemodynamic Monitoring and Therapy
- RNA modifications and cancer
- Galectins and Cancer Biology
- Fish Biology and Ecology Studies
- Sepsis Diagnosis and Treatment
- Veterinary medicine and infectious diseases
- Parasitic Infections and Diagnostics
- Peripheral Neuropathies and Disorders
- Quinazolinone synthesis and applications
- Toxin Mechanisms and Immunotoxins
- Polysaccharides and Plant Cell Walls
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
- Myasthenia Gravis and Thymoma
- Bone health and osteoporosis research
Scripps Institution of Oceanography
2024
San Diego Biomedical Research Institute
2024
Children's Hospital of Los Angeles
2010-2024
University of Southern California
2024
University of Kansas
2019-2023
University of Missouri–St. Louis
2022
University of Michigan
2019
Johns Hopkins University
2003-2011
A major problem in the chemotherapy of HIV-1 infection is appearance drug resistance. In case protease inhibitors, resistance originates from mutations molecule that lower affinity inhibitors while still maintaining a viable enzymatic profile. Drug can be classified as active site or non-active depending on their location within molecule. Active directly affect drug/target interactions, and action readily understood structural terms. Non-active influence binding distal locations, mechanism...
Retrospective analysis.To determine if an infusion of bupivacaine will reduce the need for intravenous opioids following posterior spine fusion.Adolescent idiopathic scoliosis is estimated to occur with a frequency 1% 3% among at-risk age group 10 18 years. A small percentage these patients require surgical intervention. Data are limited regarding continuous local anesthetic after fusion pain control. METHODS.: review children years admitted tertiary care, 20-bed pediatric intensive care...
Our aim was to confirm whether extreme hyperoxemic events had been associated with excess mortality in our diverse critical care population.
Cancer-associated alterations to glycosylation have been shown aid cancer development and progression. An increased abundance of high mannose N-glycans has observed in several cancers. Here, we describe the preparation lectin drug conjugates (LDCs) that permit toxin delivery cells presenting N-glycans. Additionally, demonstrate low levels can be rendered sensitive LDCs by co-treatment with a type I mannosidase inhibitor. Our findings establish an glycocalyx leveraged enable delivery.
A new bench-stable trifluoromethylation reagent, phenyl bromodifluoroacetate, converts readily available alcohols to trifluoromethanes in a Cu-catalyzed deoxytrifluoromethylation reaction. This reaction streamlines access target biologically active molecules, and should be useful for variety of medicinal, agricultural, materials chemists.
Pancreatic islet-reactive B lymphocytes promote Type 1 diabetes (T1D) by presenting an antigen to islet-destructive T cells. Teplizumab, anti-CD3 monoclonal, delays T1D onset in patients at risk, but additional therapies are needed prevent the disease entirely. Therefore, bifunctional molecules were designed selectively inhibit T1D-promoting anti-insulin cells conjugating a ligand for cell inhibitory receptor CD22 (i.e., CD22L) insulin, which permit these concomitantly bind receptors (BCRs)...
The abundance of sialic acid-containing glycans in the glycocalyx malignant cells enables immune evasion. Here, we leverage biosynthetic pathways that permit pervasive sialylation to incorporate a chimeric antigen receptor (CAR) ligand into cell glycans, and demonstrate this increases susceptibility cytolytic activity CAR-expressing natural killer (NK) cells. Specifically, applied C-9-functionalized nonnatural acid [i.e., fluorescein (FL-SA)] modify glycans. We confirm metabolic...
Kifunensine is a known inhibitor of type I α-mannosidase enzymes and has been shown to have therapeutic potential for variety diseases application in the expression high-mannose N-glycan bearing glycoproteins; however, compound's hydrophilic nature limits its efficacy. We previously synthesized two hydrophobic acylated derivatives kifunensine, namely, JDW-II-004 JDW-II-010, found that these compounds were over 75-fold more potent than kifunensine. Here we explored effects on different mice...
Madagascar is a threatened global biodiversity hotspot and conservation priority, yet we lack broad-scale surveys to assess across space time. To fill this gap, collated camera trap surveys, capturing species occurrences within into single standardized database. This data set includes nine distinct protected areas of encompasses 13 subprojects, 38 arrays, 1156 sampling units (independent site per survey) two important eco-regions: western dry deciduous forest eastern humid rainforest. Camera...
Abstract Natural Killer (NK) cells utilize effector functions, including antibody-dependent cellular cytotoxicity (ADCC), for the clearance of viral infection and malignancies. NK cell ADCC is mediated by Fc γ RIIIa (CD16a) binding to fragment crystallizable (Fc) region immunoglobulin G (IgG) within immune complexes on a target surface. While antibody-induced clustering CD16a thought drive ADCC, molecular basis this activity has not been fully described. Here we use MINFLUX nanoscopy map...
<p>PDF file, 450K, Supplementary Figure 1. The length distribution of reads for ten miR-seq samples 2. Flow diagram illustrating microRNA quantification techniques used and sample sizes each step the analysis. NAT: normal adjacent tissue. Supplemental 3. Identification differentially expressed miRNAs between N0 N1+ groups patients. 4. receiver operator characteristic (ROC) curve as well area under (AUC) was determined using CART. results show that AUC is 0.79 in 43 lung ADC (cohort 1...
<p>PDF file, 64K.</p>
<p>PDF file, 450K, Supplementary Figure 1. The length distribution of reads for ten miR-seq samples 2. Flow diagram illustrating microRNA quantification techniques used and sample sizes each step the analysis. NAT: normal adjacent tissue. Supplemental 3. Identification differentially expressed miRNAs between N0 N1+ groups patients. 4. receiver operator characteristic (ROC) curve as well area under (AUC) was determined using CART. results show that AUC is 0.79 in 43 lung ADC (cohort 1...
<p>PDF file, 64K.</p>