A5101517922- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Polyoxometalates: Synthesis and Applications
- Cardiac Structural Anomalies and Repair
- Hepatitis B Virus Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Hepatitis C virus research
- Vanadium and Halogenation Chemistry
- Analytical Chemistry and Sensors
- Mass Spectrometry Techniques and Applications
- Nanocluster Synthesis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Liver Disease Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- MXene and MAX Phase Materials
- Peptidase Inhibition and Analysis
- Covalent Organic Framework Applications
- Building materials and conservation
- Andrographolide Research and Applications
Qiqihar University
2014-2024
Jiamusi University
2024
Southern University of Science and Technology
2019-2024
Shenzhen Third People’s Hospital
2009-2023
Zhejiang Hospital
2019-2022
First Affiliated Hospital of University of South China
2010-2016
University of South China
2010-2016
China Pharmaceutical University
2012
SIM0417 (SSD8432) is an orally administered coronavirus main proteinase (3CL
Abstract Covalent organic frameworks (COFs) as a novel stationary phase have attracted much attention in the field of chromatography owing to their permanent nanoscale porosity, higher surface area, and exceptional stabilities. Here, isocyanate‐β‐cyclodextrin‐modified COF (MDI‐β‐CD‐modified COF) was synthesized using isocyanate‐β‐cyclodextrin chiral selector imine‐based TpPa‐1 matrix by bottom‐up strategy. The reaction condition structure MDI‐β‐CD‐modified were optimized characterized X‐ray...
A novel chiral stationary phase (CSP) of Zr-based metal-organic framework, l-Cys-PCN-224, was prepared by one-pot method and applied for the enantioseparation capillary electrochromatography. The CSP characterized X-ray diffraction, thermogravimetric analysis, photoelectron spectroscopy, Fourier-transform infrared spectra, nitrogen adsorption/desorption, circular dichroism spectrum, zeta-potential, so on. results revealed that had good crystallinity, high specific surface area (2580 m2 /g),...
Atherosclerosis (AS) is a cardiovascular disorder accompanied by endothelial dysfunction. Extensive evidence demonstrates the regulatory functions of long noncoding RNAs (lncRNAs) in disease, including AS. Here, function lncRNA small nucleolar RNA host gene 12 (SNHG12) AS progression was investigated. A cell model established human umbilical cells (HUVECs) using oxidative low-density lipoprotein (ox-LDL). CCK-8, flow cytometry, TUNEL, ELISA, and western blotting analyses were performed....
MicroRNAs (miRNAs) are a type of small noncoding RNAs that often play important roles in carcinogenesis, but the carcinogenic mechanism miRNAs is still unclear. This study will investigate functions and miR-638 osteosarcoma (OS). The expression OS DNA copy number were detected by real-time PCR. effect on cell proliferation was measured CCK8 assay. Different assays, including bioinformatics algorithms, luciferase report assay, Western blotting, used to identify target gene proviral...
Surface oxygen vacancy defects and energy band can be synchronously regulated to accelerate the charge transfer in a semiconductor–molecule system for boosting surface-enhanced Raman scattering (SERS) performance of semiconductor. Herein, alkaline earth metal Sr with low electronegativity large atomic radius was selected as dopant prepare Sr-doped TiO2 (SrnTiO2) SERS substrate, which simple doping achieves synchronous regulation double (i.e., surface defect level Ti) TiO2. Abundant vacancies...
Abstract In order to use the enantioseparation capability of cationic cyclodextrin and combine advantages capillary electrochromatography (CEC) with open‐tubular (OT) column, in this study, a new OT‐CEC, coated (1‐allylimidazolium‐β‐cyclodextrin [AI‐β‐CD]) as chiral stationary phase (CSP), was prepared applied for enantioseparation. Synthesized AI‐β‐CD characterized by infrared (IR) spectrometry mass (MS). The preparation conditions AI‐β‐CD‐coated column were optimized orthogonal experiment...
Series of 3-substituted 6-aminosulfonyl-β-carbolines were designed and synthesized. In addition, the binding mode these β-carboline derivatives with cyclin-dependent kinase 2 (CDK2) was studied by means fluorescence measurements molecular docking calculation. The results showed that replacement 3-cyclohexylmethoxy group will increase hydrophobic interaction deep pocket CDK2 correlate to higher intensity.
Abstract Objective This first‐in‐man (FIM) study aimed to determine the safety and efficacy of Heartech® left ventricular partitioning device (LVPD) in patients with chronic heart failure (HF) postmyocardial infarction. Methods Sixteen were enrolled from three cardiac intervention centers China. All underwent percutaneous restoration (PVR) procedures implantation LVPD. Safety immediate success rates recorded. Major adverse cardiovascular cerebrovascular events (MACCEs) including all‐cause...
We developed a novel, convenient and low-cost one-pot strategy for preparing zeolitic imidazolate framework-8 (ZIF-8)-silica hybrid monolithic column by adding ZIF-8 directly to polymer solution of the silica matrix. The simulated stationary phase prepared under optimal conditions were characterized using X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy, thermogravimetric analysis nitrogen physisorption zeta potential. results obtained confirmed...
Background: The COVID-19 pandemic has had a profound global impact, although the majority of recently infected cases have presented with mild to moderate symptoms. Previous clinical studies demonstrated that Shufeng Jiedu (SFJD) capsule, Chinese herbal patent medicine, effectively alleviates symptoms associated common cold, H1N1 influenza, and COVID-19. This study aimed assess efficacy safety SFJD capsules in managing infection. Methods: A randomized, double-blind, placebo-controlled trial...
Pollution of the environment is becoming more and serious due to misuse antibiotics. To protect environment, polyoxometalates (POMs) emerged as potential green materials. These POMs contain anionic clusters metal oxides, which exhibit favorable structural physicochemical properties. They have demonstrated promising antiviral, antibacterial antitumor activities in biomedicine. In present study, fluconazole (FKZ)-modified Keggin structure were synthesized an efficient bacteriostatic agent by...