A5011772154- Fungal Biology and Applications
- Complement system in diseases
- Herbal Medicine Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects of Natural Compounds
- Polysaccharides and Plant Cell Walls
- Allergic Rhinitis and Sensitization
- Cell Adhesion Molecules Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phytochemistry and Bioactivity Studies
- Blood groups and transfusion
- Indoor Air Quality and Microbial Exposure
- Blood transfusion and management
- Platelet Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- S100 Proteins and Annexins
- Hepatitis C virus research
- Food Allergy and Anaphylaxis Research
- Hepatitis B Virus Studies
- Silymarin and Mushroom Poisoning
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Blood Coagulation and Thrombosis Mechanisms
- Blood disorders and treatments
University of Oslo
2014-2024
Oslo University Hospital
2014-2024
Norwegian Institute of Public Health
2003-2005
Scripps Research Institute
1994-1998
Ullevål Sykehusapotek
1992
Norwegian University of Science and Technology
1990
Institute of Immunology
1990
National Hospital for Neurology and Neurosurgery
1990
University College London
1990
University Hospital of North Norway
1986-1988
Abstract An immunostimulatory extract based on the medicinal mushroom Agaricus blazei Murill (AbM) has been shown to stimulate mononuclear phagocytes in vitro produce pro‐inflammatory cytokines, and protect against lethal peritonitis mice. The present aim was study effect of AbM release several cytokines human whole blood both after stimulation ex vivo oral intake over days healthy volunteers. 17 signal substances examined were; T helper 1 (Th1) [interleukin (IL)‐2, interferon (IFN)‐γ...
Forty patients with multiple myeloma scheduled to undergo high dose chemotherapy autologous stem cell support were randomized in a double blinded fashion receive adjuvant treatment the mushroom extract AndoSan, containing 82% of Agaricus blazei Murrill (19 patients) or placebo (21 patients). Intake study product started on day mobilizing and continued until end aplasia after chemotherapy, period about seven weeks. Thirty-three evaluable for all endpoints, while 40 included survival...
The aim was to investigate the antibacterial effect of biologically active and edible mushroom Agaricus blazei Murill (AbM). A water extract AbM or PBS control administered orally before with challenge NIH/OlaHsd mice, experimentally infected intraperitoneally moderately virulent Streptococcus pneumoniae serotype 6B. End points were bacteraemia survival rate. extract, protected against systemic S. 6B infection in mice. It most effective when given 24 h inoculation but did also have...
A female blood donor at our institution was implicated in three cases of clinical posttransfusion hepatitis B. She had given 25 times 8 years. Twenty-seven recipients were followed up, and about one-half those who still living serologic markers B virus (HBV) infection. The repeatedly negative for surface antigen (HBsAg) antibody, but she high titers antibody to core antigen. We conclude that from this HBsAg-negative capable transmitting
Abstract An immunomodulatory extract (AndoSan™) based on the medicinal mushroom Agaricus blazei Murill (AbM) has shown to reduce blood cytokine levels in healthy volunteers after 12 days’ ingestion, pointing an anti‐inflammatory effect. The aim was study whether AndoSan™ had similar effects cytokines patients with ulcerative colitis (UC) and Crohn’s disease (CD). Calprotectin, a marker for inflammatory bowel (IBD), also measured. Patients CD ( n = 11) UC 10) consumed 60 ml/day of AndoSan™....
The medicinal mushroom Agaricus blazei Murill from the Brazilian rain forest has been used in traditional medicine and as health food for prevention of a range diseases, including infection, allergy, cancer. Other scientists we have examined whether there is scientific evidence behind such postulations. M rich immunomodulating polysaccharides, β -glucans, shown to antitumor, anti-infection, antiallergic/-asthmatic properties mouse models, addition anti-inflammatory effects inflammatory bowel...
Ingestion of AndoSan™, based on the mushroom Agaricus blazei Murill, has previously been shown to exhibit anti-inflammatory effects because reduction pro-inflammatory cytokines in healthy individuals and patients with ulcerative colitis. In this randomized single-blinded placebo controlled study we examined whether intake AndoSan™ also resulted clinical effects.50 symptomatic colitis were block-randomized blinded for oral daily or 21 days' experimental period. The reported scores symptoms,...
Monocytes cultured under serum‐free conditions secreted protein which bound covalently and non‐covalently to agarose beads, an activator of the alternative pathway complement. There was a significant binding monoclonal anti‐C3c antibodies, polyclonal anti‐C5, anti‐C6, anti‐C7, anti‐C8, anti‐C9 antibody against neoantigen polymerized C9 beads incubated with monocytes for 24, 48, 72 or 96 h. From these results, we conclude that produce C5, C6, C7, C8 assemble as terminal complement complex on...
Agaricus blazei Murill (AbM) is an edible Brazilian mushroom that has been used in traditional medicine for a range of diseases. It shown to have anti-infection and anti-tumor properties the mouse, which are due induction Th1 responses. On other hand, IgE-mediated allergy induced by Th2 response.Since according Th1/Th2 paradigm increased response may promote reduced response, aim was examine whether AbM had anti-allergy effects.A mouse model employed, mice were immunized s.c. with allergen...
Ingestion of the Agaricus blazei Murill-based mushroom extract AndoSan™ has been shown in randomized placebo-controlled studies to improve symptoms Crohn's disease (CD) and ulcerative colitis (UC) also fatigue quality life latter patients. The aim was examine whether this clinical impact intake could be explained by influence on foremost pro-inflammatory cytokines Fifty patients with symptomatic UC CD were blinded for oral daily or placebo. Blood samples taken before (visit 1) after 21 days'...
The antibacterial effect of a soluble pectin polysaccharide, PMII, isolated from the leaves Plantago major, was examined in inbred NIH/OlaHsd and Fox Chase SCID mice experimentally infected with Streptococcus pneumoniae serotype 6B. Serotype 6B is known to give more protracted infection when injected intraperitoneally into susceptible than virulent serotypes like type 4. PMII administered i.p. either once 3 days before challenge or thrice 48 h after challenge. number bacteria blood mouse...
AIMS: To determine whether the chemotaxins C5a and formyl peptide (fMLP) can stimulate release of calprotectin, major leucocyte protein polymorphonuclear neutrophils (PMN). METHODS: A dose response curve for uptake 125I labelled rC5a fMLP in PMN was determined by radioimmunoassay. The unlabelled were then incubated with concentration calprotectin lysates supernatants measured an enzyme immunoassay. RESULTS: Both induced from a dependent manner as reduction intracellular concentration....
Allergy to indoor allergens can cause frequent and severe health problems in children. Because little is known about the content of environments Norway, we wanted assess levels cat, dog mite schools day-care centers Oslo. Allergen dust samples from 155 classrooms 81 units were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits. Additionally, endotoxin 31 units, limulus amebocyte lysate test. Most contained detectable amounts cat allergens. In mattress floor...
Background Ingestion of AndoSanTM, based on the mushroom Agaricus blazei Murill, has previously shown an anti-inflammatory effect through reduction pro-inflammatory cytokines in healthy individuals and patients with Crohn's disease (CD). In this randomized single-blinded placebo-controlled study we examined whether intake AndoSanTM also resulted clinical effects. Methods Findings 50 symptomatic CD were for oral daily consumption or placebo a 21-day experimental period, per-protocol study....
Bacterial septicemia is frequently occurring during gastroenterological surgery. Because of increasing problems in hospitals with bacteria developing multiresistance against antibiotics, prophylactic treatment using immunomodulators interesting. We have examined the putatively anti-infective immunomodulatory action edible mushroom, Agaricus blazei Murill (AbM), an experimental peritonitis model BALB/c mice. The mice were orally given extract AbM or phosphate-buffered saline 1 day before...
Coronavirus disease 2019 (COVID-19) displays clinical heterogeneity, but little information is available for patients with mild or very early disease. We aimed to characterize biomarkers that are useful in discriminating the hospitalization risk a COVID-19 cohort from Northern Italy during first pandemic wave. enrolled and followed four weeks 76 symptomatic SARS-CoV-2 positive age/sex-matched healthy controls. Patients were discharged (n.42), remaining hospitalized (n.34). Blood was...
The effect of β-1,3-d-glucans SSG, from Sclerotinia sclerotiorum, or soluble (sMG) particulate (pMG) MacroGard® baker's yeast on growth Mycobacterium tuberculosis H37Rv in cultures peritoneal macrophages BALB/c mice was examined. After 24 h intracellular bacteria lysed were cultured and the number cfu counted. SSG given with challenge, but not after, reduced M. significantly. pMG, sMG, challenge had an even stronger inhibitory effect, which enhanced after serum opsonization particles....