A5027349180- Forensic Toxicology and Drug Analysis
- Smoking Behavior and Cessation
- Metabolomics and Mass Spectrometry Studies
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects and Assays
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Animal Genetics and Reproduction
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects and Toxicity Studies
- Vehicle emissions and performance
- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacogenetics and Drug Metabolism
- Synthesis and Biological Evaluation
- Pesticide Residue Analysis and Safety
- Epilepsy research and treatment
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Dental Radiography and Imaging
- Hormonal and reproductive studies
Telio (Norway)
2024
Aristotle University of Thessaloniki
2018-2024
The aim of the study was to develop a LC–MS-MS method able detect and quantify number frequently prescribed antipsychotic antidepressant drugs for toxicological purposes. Separation compounds performed on C-18 RP column by Ultra High-Pressure Chromatography over 11 min run. A modified single step QuEChERS protocol consisted essentially addition acetonitrile, potassium carbonate magnesium sulfate in 100 μL sample, vortexing, centrifugation evaporation has been selected. achieves satisfactory...
A toxicology laboratory often receives a high number of samples from cases (autopsies or clinical) that may require the quick delivery trustworthy, accurate results. Thus, there is great need for fast and reliable method capable identifying determining large drugs abuse in biological matrices, especially blood. In present study, we describe development simple gas chromatography–mass spectrometry (GC-MS) determination 41 (DOA) Sample pre-treatment by alkaline liquid–liquid extraction (LLE)...
Non-steroidal anti-inflammatory drugs (NSAIDs) are being widely consumed without medical prescription and often the cause of intoxication, usually in young children. For this, there is a special need their determination routine toxicology analysis. As screening methods mainly focus on abuse (DOA) that alkaline compounds majority, they not optimized for acidic drugs, such as NSAIDs. Thus, more specific needed detection quantification this class drugs. In study, efficient extraction NSAIDs...
Abstract Rationale Recent data suggest that passive smoking has a risk comparable to active smoking. Passive is considered dangerous in children and suspected as cause of asthma. However, some reports are opposing such claims, indicating the need for solid results large‐scale studies. This scientific work aims develop method determination nicotine (NCOT) major nicotine's metabolite cotinine (COT) urine samples, using gas chromatography–mass spectrometry (GC–MS). Methods Analysis was...
Cocaine toxicity has been a subject of study because cocaine is one the most common and potent drugs abuse. In current effect on human liver cancer cell line (HepG2) was assessed. (IC50) HepG2 cells experimentally calculated using an XTT assay at 2.428 mM. The metabolic profile further evaluated to investigate cytotoxic activity 2 mM three different time points. Cell medium intracellular material samples were analyzed with validated HILIC-MS/MS method for targeted metabolomics ACQUITY Amide...
Abstract Lacosamide is a functionalized amino acid with antiepileptic function. Therapeutic drug monitoring ( TDM ) in patients for lacosamide critical as it allows clinicians to control epileptic seizures. A single liquid–liquid extraction step was applied the of from whole blood samples which were thereafter analyzed by GC ‐ MS . Optimum conditions selected on basis experiments various solvents at different pH s, indicating ethyl acetate 12 most efficient parameters lacosamide. Method...
Recent data suggest that passive smoking has a risk comparable to active smoking. Passive is considered dangerous in children and suspected as cause of asthma. However, some reports are opposing such claims, indicating the need for solid results large-scale studies. This scientific work aims develop method determination nicotine (NCOT) major nicotine’s metabolite cotinine (COT) urine samples, using gas chromatography-mass spectrometry (GC-MS). For sample preparation, liquid-liquid extraction...
Estimation of patient's skeletal maturity in orthodontics is essential for the diagnosis and treatment planning. The aim study was to investigate potential use metabolic fingerprint saliva bone growth tooth development estimation.Saliva samples from 54 young patients were analysed by an untargeted gas chromatography-mass spectrometry metabolomics-based method. calculated with cervical vertebrae maturation method, dental age estimated Demirjian Multivariate analysis univariate performed...
Objective: Second-hand smoke exposure in children is a recognized risk factor for asthma/wheezing. Even brief can be harmful. Adult smoking prevalence Greece of the highest worldwide and pediatric asthma rates are raising. Our objective was to investigate parental habits homes with without bronchial asthma/wheezing disorders. Methods: This case-control study that included 90 aged 1, 5-17 years old subdivided into two groups: 51 39 healthy peers. SHS estimated by both questionnaires on...